Chemical Name: N-(Trimethylsilyl)Imidazole
Synonyms: 1-Trimethylsilylimidazole, TMSIM
CAS Number: 18156-74-6
EC Number: 242-058-1
Recommended Use: Analytical reagent, derivatization agent, organic synthesis
Supplier: Name of manufacturer and emergency contact details as per supplier label
Molecular Formula: C6H12N2Si
Molecular Weight: 140.26 g/mol
Address: Manufacturer’s address per packaging
Phone Number: Manufacturer’s 24-hour hotline available on shipping papers
GHS Classification: Flammable liquid (Category 2), Skin irritation (Category 2), Eye irritation (Category 2A), Specific target organ toxicity – single exposure (Category 3)
Label Elements: Flame, Exclamation mark
Signal Word: Danger
Hazard Statements: Highly flammable liquid and vapour, Causes skin irritation, Causes serious eye irritation, May cause respiratory irritation
Precautionary Statements: Keep away from heat, sparks, open flames, and hot surfaces. No smoking. Avoid breathing vapours. Wear protective gloves, clothing, and eye/face protection. Wash hands thoroughly after handling. Use only outdoors or in well-ventilated area.
Other Hazards: Vapours heavier than air and spread along floors. Risk of explosion if vapours contact strong oxidizers.
Substance: N-(Trimethylsilyl)Imidazole
CAS Number: 18156-74-6
EC Number: 242-058-1
Concentration: 98-100%
Impurities and Stabilizers: No relevant impurities known affecting hazard classification
Eye Contact: Rinse cautiously with water for at least 15 minutes. Remove contact lenses if present and easy to do. Continue rinsing and seek medical attention.
Skin Contact: Remove contaminated clothing and wash skin thoroughly with soap and water. Get medical attention if irritation persists.
Inhalation: Move to fresh air immediately. Seek medical attention if respiratory symptoms develop.
Ingestion: Rinse mouth with water. Do not induce vomiting. Get immediate medical help.
Most Important Symptoms/Effects: Redness, irritation, burning or stinging of affected tissue. Coughing or throat irritation if inhaled.
Note to Physician: Treat symptomatically. Chemical irritation may require respiratory support.
Suitable Extinguishing Media: Carbon dioxide, dry chemical, alcohol-resistant foam. Do not use direct water jet.
Specific Hazards Arising from Chemical: Releases flammable vapours. Can form toxic gases such as nitrogen oxides and silicon oxides upon thermal decomposition.
Protective Equipment for Firefighters: Self-contained breathing apparatus and full body protective suit.
Special Procedures: Remove containers from fire area if safe to do so. Use water spray to cool exposed containers.
Explosion Hazards: Vapours may form explosive mixtures with air.
Personal Precautions: Evacuate unnecessary personnel. Ventilate area. Wear gloves, eye protection, impervious clothing, and respiratory protection if required.
Environmental Precautions: Prevent further leakage and spillage. Do not allow into sewers, surface water, or groundwater.
Methods for Containment and Cleaning Up: Absorb carefully with inert material such as sand. Place in labeled waste container. Wash spill area with plenty of water. Dispose according to regulations.
Reference to Other Sections: Refer to protective measures in Section: Exposure Controls and Personal Protection
Precautions for Safe Handling: Avoid contact with eyes, skin, and clothing. Do not breathe vapour or mist. Use only with adequate ventilation. Keep containers tightly closed.
Conditions for Safe Storage: Store in a cool, well-ventilated, flame-proof area. Keep away from heat, open flame, and oxidation sources. Use only original containers, tightly sealed.
Incompatible Materials: Strong oxidizing agents, water, acids, and bases.
Storage Class: Flammable liquids storage
Packaging Materials: Use containers made from compatible materials, avoid metal.
Exposure Limits: No occupational exposure limits established.
Engineering Controls: Use fume hood or explosion-proof general exhaust ventilation.
Personal Protective Equipment:
Eye Protection: Tightly sealed goggles
Skin Protection: Chemical-resistant gloves and aprons
Respiratory Protection: Respirator meeting EN 143 standard if vapours present
General Hygiene: Do not eat, drink, or smoke during use. Wash hands before breaks and after work
Appearance: Clear, colorless to pale yellow liquid
Odour: Slight, characteristic
Odour Threshold: Not determined
pH: Not applicable
Melting Point/Freezing Point: Below -20°C
Boiling Point: 198-200°C at 1013 hPa
Flash Point: 48°C (closed cup)
Evaporation Rate: Not available
Flammability: Highly flammable liquid
Vapour Pressure: 0.48 hPa at 20°C
Vapour Density: Not available
Relative Density: 0.98 g/cm³ at 25°C
Solubility: Reacts with water, soluble in many organic solvents
Partition Coefficient (n-octanol/water): Not available
Auto-ignition Temperature: 325°C
Decomposition Temperature: Not specified
Viscosity: Not available
Chemical Stability: Stable under ordinary conditions of use and storage
Possibility of Hazardous Reactions: Reacts violently with water, alcohols, acids, and strong oxidizers
Conditions to Avoid: Heat, sparks, open flames, moisture
Incompatible Materials: Water, acids, oxidizers, bases
Hazardous Decomposition Products: Silicon oxides, nitrogen oxides, carbon oxides, methylsilanols
Acute Toxicity: Oral LD50 (rat): >2000 mg/kg. Data for similar compounds shows low risk, but expect irritation at doses above occupational limits.
Skin Corrosion/Irritation: Causes irritation. May result in redness and blistering with prolonged exposure.
Serious Eye Damage/Irritation: Causes major eye irritation. Contact leads to pain, watering, and possible injury.
Respiratory or Skin Sensitization: No evidence of sensitization currently reported.
Germ Cell Mutagenicity: Not classified
Carcinogenicity: Not classified by IARC, NTP, or OSHA
Reproductive Toxicity: Not classified
Specific Target Organ Toxicity (Single Exposure): Respiratory tract irritation
Repeated Dose Toxicity: No data available for chronic exposure
Aspiration Hazard: Not an aspiration hazard
Ecotoxicity: No reliable data for direct toxicity to aquatic or terrestrial organisms. Hazard expected due to chemical’s reactivity with water.
Persistence and Degradability: Reacts rapidly with water, hydrolyzing to ammonia derivatives and silanols
Bioaccumulation Potential: Low, based on structure and high solubility
Mobility in Soil: Moves readily in soil, but hydrolyzes to reduced hazard products
Other Adverse Effects: Not expected to cause significant ozone depletion or photochemical effects
Waste from Residues: Dispose of unused chemical as hazardous waste according to local, state, and national regulations.
Container Disposal: Triple rinse empty containers before discarding. Dispose through approved waste contractors.
Recommended Treatment: Incineration in a chemical incinerator equipped with afterburner and scrubber.
Special Precautions: Do not pour into drains or the environment.
UN Number: 1993
UN Proper Shipping Name: Flammable liquid, n.o.s. (N-Trimethylsilyl-imidazole)
Transport Hazard Class: 3 (Flammable liquids)
Packing Group: III
Environmental Hazards: Not classified as a marine pollutant
Special Precautions for User: Keep tightly sealed, upright in original packaging. Transport must comply with local and international regulations.
Document Requirements: Safety Data Sheet and emergency contact details must accompany shipment.
TSCA Status: Listed on US TSCA Inventory
REACH Status: Not registered in EU, considered for professional use only
OSHA Classification: Flammable liquid, Irritant
Other Local/International Regulations: Subject to transport and workplace safety regulations in regions of use. No specific SARA, CERCLA, or California Proposition 65 listings
Labeling Requirements: GHS and local authority-compliant labeling needed on all containers
Workplace Classification: Store and use in compliance with relevant workplace health, fire, and environmental protection codes
