MSDS: N-Propylimidazole

Identification

Product Name: N-Propylimidazole
Chemical Formula: C6H10N2
CAS Number: 24549-06-2
Synonyms: 1-Propylimidazole, NPI
Recommended Use: Chemical research, intermediate for synthesis
Supplier: Contact chemical supplier for full address
Emergency Phone: Emergency response number provided by supplier on container label

Hazard Identification

GHS Classification: Flammable liquid (Category 3), Acute toxicity (oral, Category 4), Serious eye irritation (Category 2A), Skin irritation (Category 2)
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor. Causes skin and eye irritation. Harmful if swallowed.
Pictograms: Flame, Exclamation Mark
Precautionary Statements: Keep away from heat, sparks, or open flame. Avoid breathing vapors. Wear gloves, goggles, and lab coat. Wash skin thoroughly after handling.

Composition / Information on Ingredients

Chemical name: N-Propylimidazole
Concentration: More than 98%
Impurities: Water and related imidazoles, less than 1%
Stabilizers/Additives: None identified in most typical commercial samples
Other Names: 1H-Imidazole, 1-propyl-

First Aid Measures

Inhalation: Move person to fresh air. Seek medical attention if symptoms like coughing, headache, or dizziness appear.
Skin Contact: Wash with plenty of soap and water. Remove contaminated clothing. See a doctor if irritation persists.
Eye Contact: Rinse well with water for at least fifteen minutes, holding eyelids open. Get prompt medical help.
Ingestion: Rinse mouth. Do not force vomiting. Contact a physician or poison control center without delay.
Symptoms: Burning, stinging, redness, nausea, drowsiness are common signs after exposure.

Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, water spray
Specific Hazards: Vapors can catch fire easily. Heating can produce toxic vapors like nitrogen oxides.
Protective Equipment: Wear a full self-contained breathing apparatus and protective suit.
Other Advice: Use water spray to cool exposed containers. Control run-off water and avoid pollutants reaching drains.

Accidental Release Measures

Personal Precautions: Use gloves, goggles, and chemical splash apron. Ventilate area well. Remove ignition sources.
Environmental Precautions: Prevent material from seeping into drains or waterways. Report large releases to environmental authorities.
Cleanup Procedures: Absorb with inert material like sand or vermiculite. Scoop up and place in suitable container for disposal. Wash spill site with water after material pickup is complete.

Handling and Storage

Handling: Avoid swallowing, inhaling vapors, and skin or eye contact. Only handle indoors or in a chemical fume hood. Avoid sparking equipment.
Storage: Store in a tightly sealed container. Keep in a dry, cool, well-ventilated area away from sources of ignition and incompatible materials like oxidizers. Use corrosion-resistant shelves if possible.
Other Information: Store with appropriate warning signage. Limit access only to trained personnel.

Exposure Controls and Personal Protection

Exposure Limits: No established occupational exposure limits for this compound. Use good industrial hygiene practices.
Engineering Controls: Local exhaust, fume hood, or explosion-proof ventilation strongly recommended.
Personal Protective Equipment: Safety goggles, impervious gloves, chemical-resistant lab coat, closed-toe shoes.
Hygiene Measures: Wash hands and face thoroughly after use. No eating or drinking in work area.

Physical and Chemical Properties

Appearance: Colorless to light yellow liquid
Odor: Distinct amine or imidazole-like odor
Melting Point: -34°C
Boiling Point: About 210°C
Flash Point: 93°C (closed cup)
Evaporation Rate: Slower than ether
Vapor Pressure: Low (less than 1 mmHg at 20°C)
Solubility: Miscible with water, ethanol, chloroform
Density: 1.01 g/cm³ at 20°C
pH: Alkaline (solution in water)

Stability and Reactivity

Chemical Stability: Remains stable at ordinary temperatures and pressures in tightly closed containers.
Thermal Decomposition: Produces toxic gases such as nitrogen oxides by strong heating or combustion.
Incompatible Materials: Strong oxidizing agents, acids, acid chlorides
Hazardous Reactions: Polymerization does not occur under normal usage.
Storage Concerns: Absorbs moisture. Prevent contamination by air or water for long-term storage.

Toxicological Information

Acute Toxicity: LD50 (oral, rat) estimated around 500-2000 mg/kg. Can cause nausea, vomiting, irritation.
Skin Corrosion/Irritation: Repeated contact leads to irritation or dermatitis.
Eye Damage/Irritation: Causes stinging, redness, watering.
Respiratory Effects: Inhalation of concentrated vapor brings headache, irritation, drowsiness.
Long-term Effects: No clear evidence for carcinogenicity or chronic toxicity with short-term industrial exposure. Always work under guidance.

Ecological Information

Aquatic Toxicity: Harmful to aquatic life in high concentrations. Not persistent in water, so rapid dilution or breakdown possible.
Persistence/Degradability: Readily biodegradable in the environment, but local buildup can impact sensitive organisms.
Bioaccumulation: Not likely to accumulate in biological systems.
Wastewater Considerations: Prevent large discharges to municipal drains or open waterways.

Disposal Considerations

Waste Disposal: Place waste residue and contaminated items in properly labeled containers. Hand over to certified chemical waste disposal companies.
Regulations: Comply with national, regional and local directives for hazardous waste.
Precautions: Never flush in regular trash or down the drain. Avoid open burning of hazardous residues.

Transport Information

UN Number: 2810 (Toxic Liquid, Organic, N.O.S.)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III—less risk than Class I or II, but still needs precautions
Labelling: Toxic and Flammable Liquid labels required on all packages
Special Requirements: Keep away from sparks and incompatible cargo like acids. Check for restrictions in air or water transport.

Regulatory Information

OSHA: Treated as hazardous under OSHA’s criteria
TSCA: Listed as a chemical substance under the Toxic Substances Control Act
REACH: Registered as required for import or manufacture in Europe
SARA Title III: Not listed as Extremely Hazardous, but reporting may be required for large releases
Other Designations: Follow all safety standards and rules for workplace chemical management