Product Name: N,N,4-Trimethylpiperazine-1-Ethylamine
Synonyms: 1-Ethyl-N,N,4-trimethylpiperazine
CAS Number: 116682-16-3
Recommended Use: Intermediate for chemical synthesis, potential reagent in research applications
Manufacturer Information: Provided by certified chemical supply companies, reach out through registered distributors for detailed information and support
Contact Point: Safety officer or chemical safety consultant from the sourcing entity
Emergency Telephone: Refer to manufacturer or regional poison control, as many private labs maintain support hotlines for chemical emergencies
GHS Classification: Acute Toxicity (Oral), Skin Corrosion/Irritation, Eye Damage/Irritation
Pictograms: Skull and crossbones, Exclamation mark, Corrosion symbol
Signal Word: Danger
Hazard Statements: Harmful if swallowed; causes severe skin burns and eye damage; may cause respiratory irritation; harmful if inhaled, risk of central nervous system depression at higher exposure
Precautionary Statements: Wear protective gloves, clothing, eye protection; avoid breathing vapors, use only in a chemical fume hood for safety; wash hands thoroughly after handling
Other Hazards: Liquid may be combustible and generate toxic fumes on decomposition, especially under fire conditions
Chemical Identity: N,N,4-Trimethylpiperazine-1-Ethylamine
Formula: C9H21N3
Purity: Greater than 97% as typically received from certified suppliers
Impurities: Trace levels of related piperazine by-products, structural isomers depending on synthetic route
Ingredient Concentration: Single ingredient material, not a blend or admixture, handled as a pure chemical
Inhalation: Move person to fresh air, keep them calm, monitor breathing, seek medical attention for respiratory distress; trained personnel use supplemental oxygen if available
Skin Contact: Remove contaminated clothing, wash exposed area with water and mild soap, do not apply lotions or creams, seek prompt medical attention for persistent irritation or burns
Eye Contact: Flush eyes with running water for at least 15 minutes, keep eyelids open, remove contact lenses if possible, medical assessment required for any pain, redness, or blurred vision
Ingestion: Do not induce vomiting, rinse mouth with water if conscious, drink water only if medical professional instructs, urgent transport to hospital for systemic symptoms
Notes for Healthcare Providers: Treat as exposure to irritant/corrosive alkylamines, supportive therapy based on signs and symptoms, monitor for airway swelling or chemical burns
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, avoid water on open liquid pools if soluble vapors increase fire spread
Unsuitable Media: Do not use water stream directly on product as it might cause spattering or spread contamination
Fire Hazards: Combustion produces nitrogen oxides, carbon monoxide, and other hazardous vapors; toxic, flammable gases may be released
Protective Equipment for Firefighters: Full chemical resistant suit, self-contained breathing apparatus, measures to prevent runoff of contaminated extinguishing water
Special Hazards: Closed containers may rupture under extreme heat, firefighting from upwind and safe distance improves responder protection
Personal Protection: Appropriate chemical-resistant gloves, splash-proof goggles, lab coat or apron, supplied-air respirator in high concentrations or confined spaces
Environmental Protection: Prevent liquid from entering drains, surface water, or soil, use sand or inert absorbent for spill containment
Clean-Up Procedures: Absorb spill with inert material, collect residue in sealable containers, ventilate the area, clean equipment and surfaces thoroughly after removal, dispose waste through approved channels
Decontamination: Wash all contacted surfaces with water and non-reactive detergent, avoid production of dust or aerosol during clean-up
Safe Handling Practices: Use splash shields, minimize open handling, transfer only with secure equipment, do not eat, drink, or smoke in work area
Storage Conditions: Store in a chemical cabinet, sealed and labeled, away from strong oxidizers, acids, and sources of ignition; keep out of direct sunlight; temperature control between 2°C and 8°C recommended for long shelf life
Incompatibilities: Reacts with acids, acid chlorides, strong oxidizers, avoid contact with moisture as hydrolysis can generate irritating gases
General Precautions: Use only with local exhaust ventilation, ensure all chemical storage complies with institutional safety protocols
Permissible Exposure Limits: No published PEL or TLV from OSHA or ACGIH, follow internal threshold limits set by health and safety professional review
Engineering Controls: Work in ducted chemical fume hood, emergency shower and eyewash nearby, negative pressure enclosure preferred for frequent or large scale handling
Personal Protective Equipment: Butyl or nitrile gloves, full-length lab coat, chemical goggles or face shield; respiratory protection if vapor generation expected or hood not available
Hygiene Measures: Wash hands and exposed skin after handling, proper chemical management includes decontamination of surfaces after work shifts
Appearance: Colorless to pale yellow liquid
Odor: Amine-like, penetrating, can become overpowering at higher concentrations
Boiling Point: Estimated at 150–190°C depending on sample purity
Melting Point: Below 0°C
Flash Point: Above 60°C, specific value needs laboratory confirmation
Solubility: Miscible with water, ethanol, and most polar organic solvents
Vapor Pressure: Moderate at room temperature, vapor formation increases in poorly ventilated spaces
Density: Approx. 0.90–0.98 g/cm³
Viscosity: Low, flows readily at room temperature
Partition Coefficient (log Kow): Data not widely available, presumed hydrophilic due to multiple nitrogen atoms
Chemical Stability: Stable at controlled temperatures, not prone to spontaneous decomposition under normal lab conditions
Conditions to Avoid: Exposure to strong acids, oxidizing agents, extreme heat, sunlight
Hazardous Decomposition Products: Oxides of carbon, nitrogen, ammonia; toxic gases upon heating
Polymerization: Not known to undergo hazardous polymerization
Reactivity: Vigorous reaction with acids, acid chlorides, and certain oxidizers, sometimes producing heat and toxic vapors
Routes of Exposure: Skin contact, inhalation, ingestion, eye exposure all pose significant risk
Acute Effects: Severe irritation, chemical burns on skin and mucous membranes, risk of eye damage, nausea, vomiting, headache, dizziness upon ingestion or inhalation
Chronic Effects: Prolonged or repeated contact may result in dermatitis, possible liver or kidney stress depending on duration and dose
Carcinogenicity: No data from IARC, NTP, or OSHA; routine precautions minimize exposure risk
Mutagenicity: Not classified as mutagenic, but full animal testing data is limited
Sensitization: Potential respiratory or skin sensitizer after repeated exposure, especially in susceptible individuals
LD50/LC50: Estimated oral LD50 value in rat models likely ranges between 200–350 mg/kg, inhalation LC50 not established; always treat as hazardous at any dose
Aquatic Toxicity: Potential toxicity to fish and aquatic invertebrates, typical of low molecular weight alkylamines
Persistence and Degradability: Expected to biodegrade in the environment over weeks; may persist if concentrations remain high due to spillage
Bioaccumulation Potential: Unlikely to accumulate in food chains due to high water solubility and low lipid solubility
Mobility in Soil: Moves readily through soil, especially under high rainfall or in spill conditions, may leach into local water sources if not contained
Effect on Sewage Systems: High concentrations may disrupt biological treatment processes in wastewater plants
Waste Handling: Store waste in tightly sealed, correctly labeled containers, compatible with alkylamines
Disposal Methods: Controlled incineration in a licensed facility with flue gas scrubbing, do not allow to enter natural waterways or municipal drains
Packaging Disposal: Decontaminate empty containers before recycling or disposal, triple rinse with non-reactive solvent, treat as hazardous waste until rendered safe
Regulatory Guidelines: Follow local hazardous waste codes, ensure disposal by or in consultation with certified chemical waste contractors
UN Number: UN 2735
Proper Shipping Name: Amines, liquid, corrosive, n.o.s. (N,N,4-Trimethylpiperazine-1-Ethylamine)
Transport Hazard Class: 8 (Corrosive)
Packing Group: II
Label Requirements: Corrosive label on all containers and transport documentation
Environmental Hazards: Not listed as a marine pollutant, but care advised during overland and maritime shipping
Special Precautions: Protect packages from rupture, secure upright during transit, shipping staff use full PPE when handling leaks or damage
OSHA Status: Regulated as hazardous chemical under Hazard Communication Standard
TSCA Status: Listed for research and process chemistry under Toxic Substances Control Act, not for broad consumer use
REACH Information: Registration may be required for import or handling in the European Union; suppliers maintain data on chemical safety and uses
Other International Regulations: Subject to workplace safety regulations in Asia, North America, and EU; proper labeling, hazard training, and exposure controls enforced by local bodies
SDS Requirements: Full disclosure of hazards and controls supported by EHS departments, reviewed annually or with each shipment
Inventory Listing: Appears on many chemical inventory databases, safety data updated as new toxicological or environmental studies become available
