Product Name: N-Hydroxysuccinimide
Chemical Formula: C4H5NO3
CAS Number: 6066-82-6
Synonyms: NHS, 1-Hydroxypyrrolidine-2,5-dione
Recommended Use: Laboratory chemicals, biochemical applications
Manufacturer/Supplier: Check label for supplier details
Emergency Contact: Local poison control or supplier emergency line
Hazard Class: Irritant to eyes, skin, and respiratory tract
GHS Classification: Eye irritation (Category 2A), Acute toxicity oral (Category 4), Skin irritation (Category 2)
Pictogram: Exclamation mark
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, may cause respiratory irritation, harmful if swallowed, may cause skin irritation
Precautionary Statements: Avoid breathing dust, wear protective gloves/eye protection, wash hands thoroughly after handling, use only in well-ventilated areas, in case of contact with skin or eyes: rinse thoroughly with water
Chemical Name: N-Hydroxysuccinimide
Purity: Typically ≥ 98%
Impurities: Trace moisture, residual solvents, or starting materials
Molecular Weight: 115.09 g/mol
Inhalation: Move to fresh air, monitor for difficulty breathing, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, wash affected area with plenty of soap and water, seek medical advice for irritation
Eye Contact: Rinse immediately with water for at least 15 minutes, keep eyelids open, remove contacts, seek medical attention
Ingestion: Rinse mouth, drink small amount of water if conscious, do not induce vomiting, get medical help
Advice to Doctor: Treat symptomatically based on patient’s condition and exposure route
Flammability: May burn but not easily ignited
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Hazardous Combustion Products: Carbon oxides, nitrogen oxides
Specific Hazards: Dust may form explosive mixtures in air, containers can explode in heat of fire
Firefighting Procedures: Use water spray to keep containers cool, avoid direct contact with runoff from fire
Personal Precautions: Avoid inhalation and skin contact, ventilate area, use personal protective equipment including gloves and goggles
Environmental Precautions: Prevent further leakage or spillage if safe, do not let product enter drains or waterways
Cleanup Methods: Contain and collect spillage with non-combustible absorbent, place in container for disposal, clean area with water, wear suitable protective clothing during cleanup
Safe Handling: Avoid generation of dust, keep container tightly closed, use only in fume hood or well-ventilated area, avoid contact with skin, eyes, and clothes
Hygiene Measures: Wash hands and exposed skin after use, remove contaminated clothing, do not eat or drink in work area
Storage Conditions: Store in cool, dry, well-ventilated place, keep away from incompatible substances (strong acids, bases, oxidizers), protect from moisture, keep container tightly sealed when not in use, keep away from sources of ignition and direct sunlight
Exposure Limits: No occupational exposure limits set by OSHA or ACGIH as of current information
Engineering Controls: Use chemical fume hood, laboratory ventilation system, use enclosures for dust-producing operations
Personal Protective Equipment: Safety glasses with side shields or goggles, chemical-resistant gloves (nitrile or equivalent), lab coat, use appropriate mask or respirator for dust, do not handle without proper PPE
General Safety Measures: Emergency eyewash and shower stations, avoid splashes and dust generation, monitor workplace conditions regularly
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: Not available in aqueous solution
Melting Point: 88–92°C
Boiling Point: Decomposes before boiling
Flash Point: Not applicable
Solubility: Soluble in water, ethanol, and other polar solvents
Vapor Pressure: Not significant at ambient conditions
Relative Density: 1.5 at 20°C
Partition Coefficient: Not determined
Evaporation Rate: Not determined
Auto-Ignition Temperature: Data not available
Chemical Stability: Stable under recommended storage conditions
Reactivity: Not reactive under normal use
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, hazardous fumes on combustion
Conditions to Avoid: Heat, moisture, open flames, generation of dust
Polymerization: No hazardous polymerization is expected to occur
Acute Toxicity: Harmful if swallowed, irritant to skin and eyes
Potential Health Effects: Irritation to respiratory tract if inhaled, eye redness or pain, skin irritation on prolonged contact
Chronic Effects: Long-term exposure data limited, repeated exposure may cause skin or respiratory sensitization
Toxicological Data: LD50 values for oral rat: approx. 1600 mg/kg
Carcinogenicity: Not classified as carcinogen by IARC, NTP, OSHA
Mutagenicity / Reproductive Toxicity: No data indicating mutagenic or reproductive toxicity as of current research
Additional Information: Sensitization not confirmed; allergies possible in sensitive individuals on frequent contact
Ecotoxicity: Data limited for aquatic environments, possible hazard to aquatic organisms
Environmental Fate: Readily soluble in water, may leach into groundwater from spills
Persistence and Degradability: No detailed degradation studies available, assumed moderate persistence
Bioaccumulation Potential: Not expected to bioaccumulate, low log Kow
Mobility in Soil: Likely to be mobile in moist environments due to solubility
Additional Hazards: Prevent product from entering water sources to minimize environmental risk
Waste Treatment Methods: Collect for disposal as chemical waste, do not combine with common trash
Disposal Procedures: Dispose of in accordance with local, regional, and national laws, use licensed chemical waste disposal contractor
Contaminated Packaging: Dispose of as unused product, rinse containers thoroughly before disposal, label as hazardous chemical
Environmental Impact: Avoid unregulated discharge to environment, incinerate in controlled facility if permitted
UN Number: Not regulated for transport by most modes (as of latest data)
UN Proper Shipping Name: Non-hazardous chemical
Transport Hazard Class: Not classified as a transport hazard
Packing Group: No packing group assigned
Special Precautions: Secure containers, keep cool and dry, transport with compatible substances, prevent physical damage during transit
Regulations: Follow local, national, and international rules for transport of chemicals
Safety, Health and Environmental Regulations/Legislation: Not listed as hazardous under US TSCA, not on EU REACH list of Substances of Very High Concern
OSHA Status: Not regulated as hazardous under OSHA standards
SARA 313: No reportable components
WHMIS Classification (Canada): D2B: Toxic Material Causing Other Toxic Effects
Other International Regulations: Refer to country-specific guidelines and regulations
Labeling Requirements: Comply with GHS and local requirements for workplace chemical labeling
