Product Name: N-Chlorosuccinimide
Synonyms: NCS, 1-Chloropyrrolidine-2,5-dione
Chemical Formula: C4H4ClNO2
CAS Number: 128-09-6
Intended Use: Laboratory reagent, oxidizing agent, chlorinating agent
Manufacturer Contact: Provided by supplier
Emergency Contact Number: Refer to local regulatory guidelines or facility-specific references for emergency response
Classification: Oxidizing solid, Category 2; Acute toxicity (oral), Category 4; Skin irritant, Category 2; Eye irritant, Category 2A
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin irritation, causes serious eye irritation, may intensify fire (oxidizer)
Pictograms: Exclamation mark, flame over circle
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Potential Health Effects: Irritation to eyes, skin, and respiratory tract; ingestion can result in nausea, abdominal pain
Precautionary Statements: Avoid breathing dust, wash thoroughly after handling, keep away from heat and ignition sources, use in a well-ventilated area, store locked up
Chemical Name: N-Chlorosuccinimide
Common Name: NCS
Concentration: 98–100%
Impurities: Minor traces of succinimide or other related compounds, less than 2%
Molecular Weight: 133.53 g/mol
Inhalation: Move person to fresh air, monitor for respiratory difficulty; consult physician if symptoms develop
Skin Contact: Remove contaminated clothing, flush skin with running water at least 15 minutes, seek medical advice for irritation or persisting redness
Eye Contact: Rinse gently with water for at least 15 minutes, lifting eyelids, contact an ophthalmologist
Ingestion: Rinse mouth with water, provide water to drink, do not induce vomiting, contact poison control or physician
Symptoms: Burning sensation, redness, pain, possible blisters for skin; eye watering, pain, vision disturbances for eye exposure; coughing, sore throat if inhaled
Special Instructions: Medical personnel should be aware of the material involved and the precautions necessary
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide; do not use water directly on material
Special Hazards: Product can intensify fire due to oxidizing properties; hazardous gases such as chlorine, nitrogen oxides may be released
Protective Gear: Firefighters require self-contained breathing apparatus, full protective clothing
Firefighting Advice: Approach fire from upwind to avoid hazardous fumes, use water spray to cool fire-exposed containers, prevent fire runoff entering drains or water sources
Personal Precautions: Isolate area, restrict access, use personal protective equipment including gloves, goggles, and dust mask based on risk assessment
Environmental Precautions: Prevent material from entering natural waterways, soil drains, or sewer systems; notify authorities if major spill occurs
Cleanup Method: Scoop solid material into suitable containers, clean spill area with damp cloth or mop, avoid generating dust; do not return spilled chemical to original container
Disposal: Containerize cleanup materials and treat as hazardous waste in compliance with regulatory requirements
Handling Precautions: Avoid contact with skin, eyes, and clothing; prevent dust formation, work with material in fume hood or well-ventilated workspace; keep away from heat, open flames, sparks
Techniques: Use spark-proof tools and explosion-proof equipment whenever possible; keep containers tightly sealed
Storage Conditions: Store in cool, dry location in original packaging; segregate from reducing agents, acids, flammable, and combustible materials; ensure secondary containment to handle leaks or breakage
Incompatibilities: Avoid storage next to organic materials, alkalis, easily oxidized substances
Occupational Exposure Limits: No established OSHA PEL or ACGIH TLV for this compound; handle as a hazardous chemical
Engineering Controls: Use local exhaust ventilation, fume extraction or appropriate filtering units
Personal Protective Equipment: Nitrile or neoprene gloves, chemical splash goggles, laboratory coat or apron, suitable respiratory protection if dust present
Hygiene Measures: Wash hands after handling, avoid eating or drinking near work area, remove and wash contaminated clothing before reuse
Environmental Controls: Use containment such as spill trays, direct air exhaust away from people and vulnerable environments
Appearance: White crystalline powder
Odor: Faint chlorine-like odor
Odor Threshold: Not established
pH: 3.5–4.5 in 5% solution
Melting Point: 149–153°C
Boiling Point: Decomposes before boiling
Flash Point: Not applicable
Evaporation Rate: Not volatile under standard conditions
Flammability: Not flammable but acts as strong oxidizer
Explosion Limits: Not explosive; may accelerate burning in combustible materials
Vapor Pressure: Nil at room temperature
Vapor Density: Not applicable
Solubility: Slightly soluble in water, more soluble in most organic solvents
Partition Coefficient (log Kow): Not available
Auto-Ignition Temperature: No data
Decomposition Temperature: Starts to decompose before melting
Viscosity: Not applicable
Chemical Stability: Stable at ambient temperature in sealed containers, sensitive to moisture and light
Reactivity: Strong oxidizer, can react with reducing agents and organic materials
Hazardous Reactions: Exothermic reaction possible with acids, bases, and certain organic chemicals, risk of fire with combustible substances
Hazardous Decomposition Products: Chlorine, nitrogen oxides, carbon oxides
Incompatible Materials: Strong acids, amines, sulfur compounds, strong bases, finely divided metals
Conditions to Avoid: Heat, direct sunlight, moisture, incompatible chemicals
Acute Toxicity: Oral LD50 in rats recorded between 1200 and 1800 mg/kg
Skin Corrosion/Irritation: Causes mild to moderate skin irritation
Serious Eye Damage/Irritation: Causes severe eye irritation, may lead to corneal injury
Respiratory or Skin Sensitization: May cause allergic skin reactions in susceptible individuals
Germ Cell Mutagenicity: No reliable data in standard tests
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, OSHA
Reproductive Toxicity: Animal data insufficient for classification
Target Organ Effects: Respiratory tract, eyes, skin
Signs and Symptoms: Redness, pain, swelling, watering eyes, respiratory symptoms
Aquatic Toxicity: Harmful to aquatic life due to oxidation and chlorine release
Persistence and Degradability: Expected to degrade slowly; releases free chlorine into water bodies which harms aquatic organisms
Bioaccumulative Potential: Low potential for bioaccumulation based on chemical structure and behavior
Mobility in Soil: Mobile when in solution, may contaminate groundwater through leaching
Other Adverse Effects: Chemical will alter water chemistry, should not enter surface water or sewage systems
Product Disposal: Dispose of material as hazardous waste, consult local, regional, and national regulations
Packaging Disposal: Rinse containers thoroughly, puncture to prevent reuse, dispose as hazardous container waste
Waste Treatment Methods: Neutralization or controlled incineration may be possible for small quantities at approved facilities
Precautions: Prevent leaching into soil or drains during disposal, do not mix with incompatible chemicals in waste streams
UN Number: UN 3261
UN Proper Shipping Name: Corrosive solid, acidic, organic, n.o.s. (N-Chlorosuccinimide)
Transport Hazard Class: 8 (Corrosive), 5.1 (Oxidizer)
Packing Group: II
Environmental Hazards: Product harmful to aquatic environments, avoid spills during transport
Transport Precautions: Use secondary containment, label shipment containers, carry emergency response instructions, separate from incompatible materials in vehicles
US Federal Regulations: Not listed under SARA Title III Sections 302, 304, or 313; subject to hazard communication standard (OSHA 29 CFR 1910.1200)
State Regulations: Check local and state-specific hazardous substance lists
International Inventories: Listed on TSCA, EINECS/ELINCS, Canada DSL, Japan ENCS
Other Standards: Chemical Safety Assessment required for workplace use; reference Globally Harmonized System of Classification and Labeling of Chemicals (GHS) for compliant handling
