Product Name: N-Bromosuccinimide
Chemical Formula: C4H4BrNO2
Synonyms: NBS, N-Bromosuccinimide, 1-Bromopyrrolidine-2,5-dione
CAS Number: 128-08-5
Recommended Use: Laboratory reagent, brominating agent in organic synthesis
Manufacturer Contact: Emergency phone line, email, and office address as per supplier documentation
Emergency Contact: Poison control center, 24-hour emergency response hotline
Hazard Class: Oxidizing solid, Acute toxicity (oral and inhalation), Skin and serious eye damage
GHS Label Elements: Pictograms: exclamation mark, oxidizer, corrosive symbols
Signal Word: Danger
Hazard Statements: Harmful if swallowed, causes skin and eye irritation, may cause respiratory irritation, oxidizing agent, contact with combustible material may cause fire
Precautionary Statements: Keep away from heat and ignition sources, avoid inhalation and contact with skin or eyes, use only in well-ventilated area, wash hands thoroughly after handling
Other Hazards: Contact with acids liberates toxic gases, dust poses inhalation risk and irritation, does not have a low threshold for respiratory sensitization, not classified as carcinogen
Chemical Name: N-Bromosuccinimide
CAS Number: 128-08-5
Concentration: 99% and above in most commercial products
Admixtures/Impurities: Trace amounts of succinimide, hydrogen bromide can form with moisture exposure
Molecular Weight: 177.98 g/mol
Eye Contact: Rinse carefully with water for several minutes, remove contact lenses if present, seek medical advice urgently
Skin Contact: Remove contaminated clothing, wash affected area with soap and water for several minutes, seek medical attention if irritation continues
Inhalation: Move to fresh air, monitor breathing, administer oxygen if breathing is difficult, call for immediate medical help
Ingestion: Rinse mouth, do not induce vomiting, give several glasses of water, consult doctor promptly
General Notes: Immediate treatment is critical due to corrosive effects, contaminated clothing should be safely disposed of or washed before reuse
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam, avoid the use of straight streams of water
Specific Hazards: Emits toxic fumes under fire conditions (hydrogen bromide, nitrogen oxides, carbon oxides), powerful oxidizer can intensify fires if mixed with combustibles
Protective Equipment: Wear self-contained breathing apparatus and protective fire gear
Fight Fire From: Upwind position, use appropriate extinguishing agent based on surroundings, cool containers exposed to flames
Explosion Risk: Avoid friction and shock, store and transport away from flammable or reducing materials
Personal Precautions: Evacuate area, ventilate space, wear chemical splash goggles, gloves, and protective clothing
Environmental Precautions: Prevent product from entering drains and water courses, inform relevant authorities if leakage or contamination occurs
Cleanup Methods: Sweep up carefully, avoid generating dust, place in suitable sealed container for disposal, wash spill site with soap and water after material pickup
Disposal Materials: Use non-combustible absorbent (vermiculite, dry sand) for large spills, avoid combustible materials during cleanup process
Decontamination: Thoroughly wash contaminated surfaces, air spaces, and equipment after handling
Handling: Use under a chemical fume hood or well-ventilated space, avoid breathing dust or fume, do not get on skin, eyes, or clothing, use non-sparking tools, keep containers tightly sealed
Storage Conditions: Store in a cool, dry, well-ventilated area away from heat sources and sunlight, keep separate from acids, alkalis, reducing agents, and organic materials
Incompatibilities: Avoid contact with strong bases, acids, strong reducing agents, combustibles, organic matter, and metals
Special Precautions: Only trained personnel should handle, keep away from food and beverages, store in labelled chemical containers
Engineering Controls: Local exhaust ventilation, safety shower and eyewash stations in working area, closed handling systems for bulk usage
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), safety goggles, full lab coat or chemical apron, dust mask or P2/P3 filter respirator if dust is generated
Occupational Exposure Limits: Not established specifically for N-Bromosuccinimide, dust limits apply as per regional guidelines
Hygiene Measures: Prohibit eating, drinking, or smoking in areas of chemical use, wash hands and face thoroughly after handling
Environmental Controls: Use containment and proper waste collection methods to prevent release to environment
Appearance: White to off-white crystalline powder
Odor: Faint bromine-like smell
Melting Point: 173-175°C (343-347°F)
Boiling Point: Decomposes before boiling
Solubility: Slightly soluble in water, soluble in organic solvents like acetone, DMF, and DMSO
Vapor Pressure: Negligible at ambient conditions
Density: 2.48 g/cm³
pH: Slightly acidic in aqueous suspension
Partition Coefficient: Not determined
Chemical Stability: Stable in original sealed packaging, decomposes slowly in air and with moisture exposure
Hazardous Reactions: Reacts violently with strong reducing agents, acids, organic compounds, and metals
Decomposition Products: Hydrogen bromide, succinimide, possible free bromine
Incompatible Materials: Alkalis, acids, organic matter, flammable substances, powdered metals
Polymerization: Not known to occur
Acute Toxicity: LD50 (oral, rat) ranges between 180-200 mg/kg, causes serious eye and skin irritation, inhalation can irritate respiratory tract
Chronic Effects: Repeated or prolonged exposure may cause skin sensitization and dermatitis, no clear evidence of carcinogenic effects
Symptoms of Exposure: Burning, redness, pain in skin and eyes, sore throat, coughing, headaches with high dust exposure
Routes of Exposure: Ingestion, inhalation, dermal, ocular
Medical Conditions Aggravated: Pre-existing skin, respiratory or eye problems show worsening with exposure
Carcinogenic Status: Not listed by IARC, NTP, or OSHA as a carcinogen
Ecotoxicity: Toxic to aquatic organisms, may cause long-term adverse effects in aquatic environment
Persistence and Degradability: Breaks down under environmental conditions but releases hazardous bromine-containing byproducts
Bioaccumulative Potential: Limited data on bioaccumulation, expected not to persist significantly in biota
Mobility in Soil: Likely to exhibit moderate mobility based on solubility
Other Adverse Effects: Avoid uncontrolled release due to potential for persistent impacts on aquatic environments
Disposal Methods: Incineration in licensed facility preferred, chemical must never enter drains or open environment
Contaminated Packaging: Dispose in compliance with local, regional, and national regulations, use sturdy closed chemical waste containers
Special Precautions: Neutralize before disposal if directed by authorities, segregate from general and organic waste during storage and treatment
Waste Codes: Consult local or national regulations for hazardous waste codes and handling requirements
UN Number: 2811
UN Transport Name: Toxic Solid, Organic, N.O.S. (N-Bromosuccinimide)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Marine Pollutant: No
Transport Labels: Toxic, Danger, Oxidizer symbols as required by carrier
Additional Requirements: Keep in original container, secure from tipping during transit, follow all local and international shipping protocols
Compliance: Subject to regional occupational health and safety regulations for chemical hazards, falls under hazardous materials rules
Inventory Status: Listed under TSCA, EINECS/ELINCS, AICS, DSL/NDSL and other national inventories
Labeling: Appropriate GHS and local hazard labels must remain on container
Restrictions: Only qualified staff may handle and dispose under controlled conditions
Safety Assessment: Regular risk assessments and safety trainings recommended for users
