Product Name: N-Boc-Piperazine
Chemical Name: Tert-Butoxycarbonyl Piperazine
CAS Number: 57260-72-7
Synonyms: 1-Boc-Piperazine, N-tert-Butoxycarbonyl Piperazine
Recommended Use: Laboratory reagent, pharmaceutical intermediate
Manufacturer: [Insert Supplier, Address, Contact Details]
Emergency Phone Number: [Insert Emergency Contact]
UN Number: Not regulated as a dangerous good
Classification: Not classified as hazardous under GHS criteria
Signal Word: None
Hazard Statements: Mildly irritating to eyes and skin in some cases, may cause respiratory and digestive irritation if inhaled or swallowed
Pictograms: None required for this compound
Precautionary Statements: Avoid breathing dust, wash hands after handling, use protection for eyes and skin during work
Potential Health Effects: Prolonged exposure could result in discomfort, particularly for those with existing sensitivities, rare allergic reactions have been reported
Chemical Identity: N-Boc-Piperazine
Synonyms: Tert-Butoxycarbonyl Piperazine
Chemical Formula: C9H18N2O2
Molecular Weight: 186.25 g/mol
Purity: Typically >98%
Impurities: Trace amounts of unreacted piperazine, organic by-products under 2%
Hazardous Components: None present above relevant thresholds
General Advice: Move affected person away from exposure, keep at rest, monitor for worsening symptoms
If Inhaled: Remove to fresh air, provide artificial respiration if not breathing, consult a physician if symptoms persist
If on Skin: Wash thoroughly with soap and plenty of water, remove contaminated clothing, seek medical advice if irritation develops
If in Eyes: Rinse slowly with water for 15-20 minutes, remove contact lenses if present and easy to do, seek eye specialist assessment if redness or pain continues
If Ingested: Rinse mouth, do not induce vomiting, drink water if conscious, get medical attention for persistent symptoms
Note to Physician: Treat symptomatically, monitor for allergic reactions or severe irritation, provide supportive care
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, water spray
Unsuitable Extinguishing Media: Strong water jets may spread spilled solid
Hazards from Combustion Products: Releases carbon oxides, nitrogen oxides, and trace toxic vapors if heated or burned
Protective Equipment: Firefighters need self-contained breathing apparatus, protective gloves, goggles, and impervious boots
Fire Hazards: Fine dust may form explosive mixtures with air, high temperatures create irritant vapor clouds, containment by fire barriers if possible
Further Advice: Cool containers exposed to flame, evacuate area if significant smoke or vapor develops
Personal Precautions: Prevent dust, ventilate area, use gloves, goggles, and mask
Environmental Precautions: Prevent spill from entering drains and waterways, bund or absorb with inert material, report larger spills to authorities
Containment Cleanup: Collect spilled solid by sweeping or vacuuming (using explosion-proof equipment), small spills can be wiped, use moistened materials to minimize dust, dispose of in suitable waste container
Decontamination: Wash area with water and detergent after cleaning, collect washings for approved disposal
Special Considerations: Remove ignition sources, avoid contact with incompatible chemicals
Handling: Use in well-ventilated area, minimize dust creation, keep away from heat sources, avoid inhalation and contact with skin or eyes, wear clean lab coat and use chemical-resistant gloves
Hygiene Measures: Wash thoroughly after handling, refrain from eating and drinking near product, use proper labeling and dedicated equipment
Storage Conditions: Store in tightly closed containers, cool and dry storage (15-25°C), keep away from direct sunlight and incompatible materials such as oxidizers or strong acids, isolate from food and animal feed, restrict access to trained personnel
Incompatibilities: Strong oxidizers, acids, strong bases, avoid exposure to moisture
Exposure Limits: No specific workplace exposure limits set for this compound, keep general dust below 5 mg/m3 TLV
Engineering Controls: Use fume hood or adequate local exhaust, avoid accumulation of dust in the work area
Personal Protection: Safety glasses or chemical splash goggles, nitrile gloves, laboratory coat, optional particulate mask in bulk use, closed-toe shoes
Environmental Controls: Prevent contaminated air or water discharge to the environment, filter exhaust if possible, minimize bulk storage near sensitive drains
Other Protection: Ensure eyewash and safety shower available in work area, do not reuse contaminated clothing without proper laundering
Appearance: White to off-white powder or crystalline solid
Odor: Mild, not pungent
Melting Point: 75-80°C
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Slightly soluble in water, soluble in organic solvents like dichloromethane, ethanol, and acetone
Vapor Pressure: Negligible at room temperature
Relative Density: About 1.1 g/cm3 at 20°C
pH (Aqueous Solution): 6-8
Flash Point: Above 150°C (not easily flammable)
Explosive Properties: Not explosive under normal handling
Partition Coefficient (Log Kow): Not determined
Evaporation Rate: Not relevant as solid
Other Data: Stable in tightly closed container, non-corrosive to metals
Chemical Stability: Stable under dry, cool, normal conditions
Reactivity: Low reactivity, but will react with strong acids, bases, or oxidizers
Hazardous Decomposition: Carbon monoxide, carbon dioxide, nitrogen oxides, trace organic vapors on heating or burning
Polymerization: Does not undergo hazardous polymerization
Avoid Conditions: Avoid exposure to excess heat, direct sunlight, open flames
Incompatible Materials: Acidic or basic reagents, oxidizing agents, strong reducing agents
Other Stability Issues: Absorbs moisture if not adequately sealed, avoid prolonged exposure to air
Acute Toxicity Data: Limited data on acute oral, dermal, or inhalation toxicity in humans or animals, estimated to have low acute toxicity based on related compounds
Irritation: May cause slight skin or eye irritation
Sensitization: Allergic responses rare, not classified as skin sensitizer
Chronic Effects: Not associated with chronic toxicity in standard use, not mutagenic or carcinogenic under current knowledge
Routes of Exposure: Skin and eye contact most relevant, less likely by inhalation or ingestion
Symptoms of Overexposure: Redness, itching, mild cough, sore throat, upset stomach in case of accidental ingestion
Other Data: Not listed by IARC, NTP, OSHA as a carcinogen
Toxicokinetics: Not studied extensively, expected to be metabolized and excreted safely in small accidental exposures
Eco-Toxicity: Not classified as hazardous to aquatic or terrestrial life, but releases to environment should be avoided
Persistence and Degradability: Organic structure predicts moderate biodegradability, breaks down over time by hydrolysis or microbial action
Bioaccumulative Potential: Not expected to bioaccumulate due to water solubility and metabolic breakdown
Mobility in Soil: Low to moderate depending on soil type, leaching unlikely on small scales
Other Adverse Effects: None known at low concentrations; normal spill containment and disposal measures strongly reduce risk
Regulatory Listings: Not specifically listed as environmental contaminant in most jurisdictions
Waste Treatment Methods: Small quantities may be dissolved in organic solvent and incinerated under controlled conditions, large-scale surplus disposed by licensed chemical waste contractor
Container Disposal: Triple-rinse then puncture before landfilling or recycling following local regulations
Precautions: Do not dispose via sinks or normal waste streams, keep separated from household or food waste
Contaminated Packaging: Treat as chemical waste, do not reuse for food or beverage storage
Regulations: Ensure compliance with national, state, and local waste codes before disposal, obtain proper transport documentation
UN Number: Not regulated for transport
Proper Shipping Name: Not classed as dangerous good under DOT, IATA, IMDG
Class: Not applicable
Packing Group: Not assigned
Environmental Hazards: None
Transport Precautions: Prevent container breakage, isolate incompatible substances, secure during transit to prevent leaks
Special Transport Notes: Use conventional methods for non-hazardous organic solids, check for updates if shipping across borders or in large volumes
Classification: Not classified as hazardous under global GHS, OSHA, EU CLP
TSCA Status: Listed or exempt in most inventories
REACH Registration: Exempt as research/lab chemical below threshold quantities
California Prop 65: Not listed
SARA Title III: Not classified as extremely hazardous
Labeling Requirements: Standard chemical label with name, hazard pictograms if applicable, and supplier information
Workplace Regulations: Follow appropriate chemical hygiene and risk assessment under 29 CFR 1910.1200 or local workplace safety requirements
