Product Name: N-Acetylimidazole
Chemical Family: Acetylating Agent
Chemical Formula: C5H6N2O
Synonyms: 1-Acetylimidazole
CAS Number: 2466-76-4
Recommended Use: Intermediate in chemical synthesis, protein acetylation in research
Supplier Details: Company name, address, phone, email (provided by manufacturer)
Emergency Contact: Chemtrec or local poison control contact
GHS Classification: Causes skin irritation, causes serious eye irritation, harmful if swallowed, may cause respiratory tract irritation
Signal Word: Warning
Hazard Statements: H315 - Causes skin irritation; H319 - Causes serious eye irritation; H335 - May cause respiratory irritation; H302 - Harmful if swallowed
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust or vapors, wash thoroughly after handling, use protective gloves and eye protection, do not eat, drink or smoke during use
Other Hazards: May form combustible dust concentrations in air, avoid dust generation
Chemical Name: N-Acetylimidazole
Common Name/Synonyms: 1-Acetylimidazole
CAS Number: 2466-76-4
Concentration: 98-100% (pure form)
Impurities: Trace solvent residues or starting material below 1%
Eye Contact: Rinse thoroughly with water for at least 15 minutes, remove contact lenses if present and easy to do, seek medical attention if irritation persists.
Skin Contact: Wash off with soap and plenty of water, remove contaminated clothing, consult a physician if irritation develops.
Inhalation: Move person to fresh air, keep comfortable for breathing, seek medical advice if symptoms occur.
Ingestion: Rinse mouth, do not induce vomiting, drink water if conscious, get medical help.
Symptoms: Redness, irritation, burning sensation in eyes or on skin, coughing or difficulty breathing after inhalation, stomach upset after ingestion.
Suitable Extinguishing Media: Dry chemical, carbon dioxide, water spray, foam
Unsuitable Media: High volume water jets may spread the material
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides, irritating fumes
Protective Equipment for Firefighters: Positive pressure self-contained breathing apparatus, full protective suit
Special Hazards: Dust accumulation presents risk of explosion, heat may release hazardous gases
Advice: Evacuate area, fight fire from safe distance, cool exposed containers with water spray
Personal Precautions: Wear protective gloves, goggles, dust mask or respirator, prevent skin and eye contact
Environmental Precautions: Avoid discharge to drains or natural environment, ventilate area
Methods for Clean Up: Sweep up and place in suitable closed container, minimize dust generation, dispose according to regulations, wash spill area
Advice for Emergency Responders: Use personal protective equipment, restrict access to trained personnel
Handling Precautions: Wear personal protective gear, avoid inhaling dust or vapors, wash hands after use, handle in well-ventilated area, keep away from open flames or sources of ignition
Storage Requirements: Store tightly closed in cool, dry, ventilated area, separate from incompatible chemicals like oxidizers, acids, bases
Incompatibilities: Strong oxidizing agents, strong acids and bases, moisture
Further Information: Label containers clearly, keep out of reach of children, store away from food or drink
Occupational Exposure Limits: No specific data available; handle as hazardous material
Engineering Controls: Use local exhaust ventilation, enclose processes if possible
Personal Protection: Gloves (nitrile or neoprene), chemical safety goggles, suitable laboratory coat, NIOSH-approved dust mask or respirator if airborne concentration expected
Hygiene Measures: Wash hands before breaks and at end of work, remove and wash contaminated clothing
Environmental Controls: Prevent material from entering water systems, use containment methods for powder
Appearance: Off-white to beige crystalline powder
Odor: Faint, acetic
Odor Threshold: Not established
pH: Not applicable in solid state
Melting Point/Range: 87-91°C
Boiling Point/Range: Decomposes before boiling
Flash Point: Not available (solid material)
Evaporation Rate: Not relevant
Flammability: Dust may be combustible
Explosive Properties: Fine dust may form explosive mixtures with air
Vapor Pressure: Negligible
Vapor Density: Not available
Relative Density: Not determined
Solubility: Slightly soluble in water, soluble in organic solvents like ethanol and acetone
Partition Coefficient (n-octanol/water): Not known
Autoignition Temperature: Not determined
Decomposition Temperature: Higher than 100°C (releases acetic acid and imidazole)
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions, sensitive to moisture and strong acids or bases
Reactivity: Reacts with water to release acetic acid and imidazole
Conditions to Avoid: High temperatures, moisture, open flames, sources of ignition
Incompatible Materials: Oxidizing agents, acids, bases
Hazardous Decomposition Products: Acetic acid, imidazole, nitrogen oxides, carbon oxides
Polymerization: Will not occur
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Harmful if swallowed or inhaled, causes irritation to eyes, skin and respiratory tract
Chronic Effects: Prolonged contact may cause skin dryness or cracking, repeated inhalation may cause respiratory symptoms
Symptoms: Eye irritation, skin redness, cough, sore throat, stomach upset
LD50 (Oral, Rat): Not specifically determined, similar acetylation reagents LD50 values range above 300 mg/kg
Sensitization: Not classified as sensitizer
Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic according to available data
Reproductive Toxicity: No known effects
Further Health Effects: No evidence of specific organ toxicity; consult MSDS for updates.
Ecotoxicity: No specific data for aquatic toxicity; material may hydrolyze and release acetic acid, which can lower pH of water
Persistence and Degradability: Hydrolyzes in water to imidazole and acetic acid, both readily biodegradable
Bioaccumulation Potential: Not expected
Mobility in Soil: High mobility if spilled, soluble in organic solvents, may leach in soil
Other Adverse Effects: Avoid release to environment, product breakdown may affect local pH balance
Disposal to Sewage System: Not recommended
Waste Treatment Methods: Incinerate in chemical incinerator equipped with afterburner and scrubber, collect and dispose of residues according to local regulations
Unused Product: Place in tightly sealed container, hand over to hazardous waste disposal firm
Contaminated Packaging: Rinse before recycling or disposal, treat rinsate as hazardous waste
Precautions: Wear suitable protective equipment, avoid generating dust during disposal
UN Number: Not classified as dangerous for transport
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Proper Shipping Name: N-Acetylimidazole
Special Precautions: Protect from moisture and strong physical shocks, keep container tightly closed during transport
Transport Labels: No additional hazard label required
Other Transport Data: Follow general chemical transport practices, consult DOT, IATA, IMDG guides for updates if shipping large amounts
TSCA (USA): Listed
DSL (Canada): Listed
REACH (EU): Not specifically registered, research use only
OSHA: Considered hazardous by classification
SARA Title III: Not listed as a reportable substance
California Prop 65: Not listed
Other National/State/Local Regulatory Listings: Check site-specific requirements
Restrictions: For laboratory, research, or industrial use, keep documentation accessible for all handlers
