Material Safety Data Sheet: Methyl 2-Oxopyrrolidin-1-Acetate

Identification

Product Name: Methyl 2-Oxopyrrolidin-1-Acetate
Chemical Formula: C7H11NO3
Synonyms: N-Acetyl Proline Methyl Ester
CAS Number: 24666-56-6
Recommended Use: Laboratory chemicals, synthesis intermediates
Manufacturer: Provided upon request
Contact Information: Provided upon request
Emergency Contact Number: Provided upon request

Hazard Identification

Globally Harmonized System (GHS) Classification: Eye irritation Category 2A, Skin irritation Category 3
Signal Word: Warning
Hazard Statements: Causes eye irritation, may cause mild skin irritation
Pictograms: Exclamation mark
Precautionary Statements: Avoid contact with eyes, wash thoroughly after handling, wear protective gloves and eye protection
Potential Health Effects: Inhalation may cause respiratory tract irritation, ingestion can lead to discomfort in the gastrointestinal system, both skin and eye contact could result in mild irritation
Environmental Hazards: Not classified as hazardous for the environment, but unnecessary release should be avoided

Composition / Information on Ingredients

Chemical Name: Methyl 2-Oxopyrrolidin-1-Acetate
Purity: ≥98%
CAS Number: 24666-56-6
Impurities: Not specified
Additives: None

First Aid Measures

Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if present and easy to do, continue rinsing, seek medical attention if irritation persists
Skin Contact: Wash exposed area with soap and plenty of water, seek medical advice if irritation develops
Inhalation: Move person to fresh air, keep comfortable for breathing, contact a physician if symptoms appear
Ingestion: Rinse mouth, do not induce vomiting, drink water to dilute, seek medical attention if feeling unwell
Symptoms: Redness, discomfort, irritation
Note to Physician: Treat symptomatically based on clinical judgement

Fire-Fighting Measures

Suitable Extinguishing Media: Use foam, carbon dioxide, dry chemical, or water spray
Unsuitable Media: High-pressure water jets may spread the material
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides
Protective Equipment for Firefighters: Full protective gear and self-contained breathing apparatus
Special Procedures: Cool exposed containers with water spray, prevent fire-fighting runoff from entering drains

Accidental Release Measures

Personal Precautions: Wear gloves, protective clothing, eye protection, ventilate area
Environmental Precautions: Prevent further leakage or spillage, avoid discharge into drains and surface water
Methods for Cleanup: Soak up with inert absorbent material, collect in suitable, closed containers for disposal, clean contaminated surface thoroughly

Handling and Storage

Precautions for Safe Handling: Use only in well-ventilated areas, avoid breathing vapors or dust, prevent contact with skin and eyes, keep containers tightly closed
Storage Conditions: Store in original tightly closed container in a dry, cool, and well-ventilated place away from sources of ignition and incompatible materials, protect from light and moisture
Incompatible Materials: Strong oxidizing agents, strong acids

Exposure Controls and Personal Protection

Exposure Limits: No occupational exposure limits established for this compound
Engineering Controls: Use with local exhaust ventilation or in a fume hood to minimize exposure
Personal Protection: Protective gloves made of chemical-resistant materials, safety goggles, lab coat or apron, respiratory protection if ventilation is insufficient
General Hygiene: Wash hands and face after using, take off contaminated clothing and wash before reuse

Physical and Chemical Properties

Appearance: White to off-white crystalline solid or powder
Molecular Weight: 157.17 g/mol
Odor: Mild, characteristic odor
Melting Point: 68 – 72°C
Boiling Point: Not available
Flash Point: >100°C
Solubility: Soluble in water, ethanol, and organic solvents
Density: Approximately 1.2 g/cm³
pH: Not determined
Vapor Pressure: Negligible at ambient temperature
Partition Coefficient (Log Kow): Not determined

Stability and Reactivity

Chemical Stability: Stable under normal handling and storage conditions
Reactivity: Does not react rapidly with air or water
Hazardous Reactions: Reacts with strong oxidizers
Conditions to Avoid: Heat, flames, sparks, exposure to sunlight, moisture
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides
Polymerization: Not expected to occur

Toxicological Information

Acute Toxicity: Low toxicity expected, not fully tested
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Symptoms of Exposure: May cause mild irritation to eyes and skin, inhalation may cause coughing or mild respiratory discomfort, ingestion can produce stomach upset
Chronic Effects: No long-term adverse effects anticipated with recommended handling
Carcinogenicity, Mutagenicity, Reproductive Toxicity: No data available, not listed as carcinogen by IARC, NTP, or OSHA
Sensitization: Data not reported

Ecological Information

Aquatic Toxicity: Not expected to be highly toxic to aquatic organisms
Persistence and Degradability: Not persistent under environmental conditions, expected to biodegrade
Bioaccumulation Potential: Low, limited bioaccumulation expected
Mobility in Soil: May leach into groundwater if released in large amounts
Other Adverse Effects: None anticipated under normal use

Disposal Considerations

Waste Disposal Methods: Dispose of as chemical waste in accordance with local, regional, and national regulations
Contaminated Packaging: Rinse thoroughly, send to approved waste disposal facility
Special Precautions: Do not allow product to enter drains, waterways, or soil

Transport Information

UN Number: Not regulated for transport
UN Proper Shipping Name: Not classified as dangerous goods
Transport Hazard Class: Non-hazardous
Packing Group: Not assigned
Environmental Hazards: Not a marine pollutant
Special Transport Precautions: Protect from physical damage, store upright, keep away from incompatible substances

Regulatory Information

OSHA Hazard Communication Standard: Not classified as a hazardous chemical
SARA Title III (Sections 311/312): Non-hazardous
TSCA Status: Listed
REACH Registration: For use in research and development, not subject to full registration
Other Regulations: Not regulated under CWC, not listed in California Proposition 65
Labeling Requirements: Standard laboratory chemical labeling, GHS compliance where applicable