Product Name: Laccase
Chemical Family: Oxidoreductase Enzyme
CAS Number: 80498-15-3
EC Number: 232-715-1
Synonyms: p-Diphenol:dioxygen oxidoreductase, EC 1.10.3.2
Recommended Use: Industrial applications, biotechnology, textile processing, bioremediation, paper and pulp industries
Supplier Details: Available upon request
Emergency Contact: Refer to regional poison control center
GHS Classification: Respiratory Sensitizer (Category 1), Skin Sensitizer (Category 1), Eye Irritant (Category 2B)
Signal Word: Warning
Hazard Statements: May cause respiratory and skin sensitization. May provoke mild irritation to eyes and skin. May cause allergic reactions through inhalation or after direct contact.
Precautionary Statements: Wear personal protective gear. Avoid inhaling dust or aerosols. Wash thoroughly after handling. Prevent release to the environment.
Pictograms: Exclamation Mark, Health Hazard
Chemical Name: Laccase Enzyme Protein
Concentration: 100% (may appear as powder, solution, or immobilized form)
Impurities: May contain stabilizers or inactive protein fractions depending on source and manufacturing process
Additional Components: Potassium phosphate buffer, minor salts or preservatives (used in liquid preparations, present in trace amounts)
Inhalation: Move affected person to fresh air promptly. Seek medical attention if symptoms arise such as wheezing, coughing, or difficulty breathing.
Skin Contact: Rinse with plenty of water and mild soap. Take off contaminated clothing. Contact a physician if irritation or sensitization occurs.
Eye Contact: Rinse slowly and gently with water for several minutes. Remove contact lenses if present. Continue rinsing and seek medical attention for persistent irritation.
Ingestion: Rinse mouth thoroughly. Do not induce vomiting. Seek medical advice if adverse effects develop.
Most Important Symptoms/Effects: Sensitization (asthma-like symptoms), dermatitis, eye redness or irritation.
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Unsuitable Extinguishing Media: High volume water jet, direct stream may spread powder
Special Hazards: Proteinaceous materials decompose upon burning, producing irritating fumes, including nitrogen oxides, carbon oxides
Protective Equipment: Self-contained breathing apparatus, full protective gear
Specific Methods: Isolate fire area. Prevent runoff from entering drains or waterways. Cool exposed containers with water spray.
Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides, possibly traces of ammonia
Personal Precautions: Wear gloves, goggles, and dust respirator. Avoid breathing dust. Evacuate unnecessary personnel.
Environmental Precautions: Prevent material from entering drains, surface water, and soil.
Spill Containment: Sweep up material gently; minimize dust generation. Collect spills in suitable, labeled containers for proper disposal. Wash spill area with plenty of water.
Decontamination: Avoid release to the environment. Clean up with absorbent materials if liquid, or dampen solid material to suppress dust.
Handling: Minimize airborne exposure. Avoid breathing dust or spray mist. Handle in well-ventilated areas. Wash hands thoroughly after handling.
Storage Conditions: Store tightly closed in original container at 2–8°C in a cool, dry, well-ventilated area. Do not freeze. Keep away from strong acids, bases, and oxidizing agents.
Incompatibles: Strong acids, alkalis, oxidizers
Special Instructions: Protect from sunlight and moisture.
Occupational Exposure Limits: No established OSHA, ACGIH, or NIOSH limits for laccase protein
Engineering Controls: Local exhaust ventilation, eye wash stations, safety showers
Personal Protective Equipment: Nitrile or latex gloves, lab coat or apron, goggles or face shield, N95 or P2 dust mask or respirator where dust may form
Hygiene Measures: Avoid skin, eye, and respiratory contact. Do not eat, drink, or smoke when using this product. Wash hands before breaks and after work.
Appearance: Fine powder (off-white to pale brownish) or liquid (amber to brown)
Odor: Mild proteinaceous odor
Odor Threshold: Not established
pH (Typical): 4.0–8.0 (as supplied in buffer); functional activity dependent on formulation
Melting Point/Freezing Point: Not applicable (decomposes before melting)
Boiling Point: Not determined
Flash Point: Not flammable
Evaporation Rate: Not applicable
Flammability: Not classed as flammable, but organic dust can form explosive mixtures in air
Vapor Pressure: Not applicable
Solubility: Soluble in water (solutions); insoluble in organic solvents
Partition Coefficient: Not available
Decomposition Temperature: Above 60°C
Viscosity: Not applicable to powders; liquid preparations vary by concentration
Other Properties: Enzyme activity decreases outside recommended storage range. Forms dust when dry.
Chemical Stability: Stable under recommended storage conditions. Loses activity on exposure to high temperatures, acids, or bases.
Reactivity: Reacts with oxidizable organic substrates. Avoid strong oxidizing and reducing agents.
Possibility of Hazardous Reactions: None expected under normal conditions
Conditions to Avoid: High heat, direct sunlight, acid or alkali exposure, strong oxidizers
Decomposition Products: Nitrogen oxides, carbon dioxide, carbon monoxide, other organic compounds
Acute Toxicity: Oral and dermal LD50 not determined; considered low toxicity
Skin Irritation: May cause mild to moderate irritation
Eye Irritation: May produce redness or discomfort
Respiratory Sensitization: Can induce allergic asthma reactions after repeated inhalation exposure
Skin Sensitization: Rare cases of allergic dermatitis in susceptible individuals
Chronic Effects: Long-term inhalation exposure not well studied; repeated exposure may increase sensitivity
Carcinogenicity/Mutagenicity: Not classified or expected based on current knowledge
Target Organ Effects: Airways, skin, eyes
Medical Conditions Aggravated: Asthma, allergies, skin conditions
Ecotoxicity: Practically non-toxic at relevant concentrations. Enzymes biodegrade in the environment.
Persistence and Degradability: Biodegradable, rapidly broken down by microorganisms.
Bioaccumulation Potential: Negligible; enzymatic proteins do not significantly accumulate in living tissue.
Mobility in Soil: High water solubility means enzyme can move with water; binds poorly to soil.
Other Adverse Effects: Unlikely to harm aquatic organisms or plants at levels commonly encountered.
Product Disposal: Dispose according to local, regional, and national regulations. Small amounts can be diluted and flushed with plenty of water. Avoid discharge to natural surface water.
Container Disposal: Rinse empty containers thoroughly. Dispose or recycle in accordance with local waste management requirements.
Reactivity in Disposal: Laccase decomposes naturally; no hazardous residues expected.
Special Notes: Avoid uncontrolled release to the environment. Inform authorities if large spill enters waterways.
UN Number: Not regulated as hazardous material
UN Proper Shipping Name: Not classified
Transport Hazard Class: Non-hazardous
Packing Group: Not applicable
Marine Pollutant: No
Special Transportation Precautions: Keep container closed, protect from physical damage and temperature extremes.
Transport Requirements: Observe safety practices and local regulations.
Labeling Requirements: GHS hazard and precautionary statements required on containers.
TSCA Status: Not specifically listed; received exemption as naturally occurring protein.
REACH Status: Exempt or registered as enzyme protein, depending on manufacturer.
OSHA Classification: Not classified as hazardous under OSHA regulations, but dust is regulated due to potential respiratory sensitization.
Other Regulations: Complies with biotechnological and enzyme-specific health and safety rules worldwide; regional labeling may vary.
Workplace Hygiene: Workplace monitoring for protein dust and enzyme aerosols recommended when handling dry forms.
