Material Safety Data Sheet for L-(Pyrrolidin-1-Yl)Methanol

Identification

Product name: L-(Pyrrolidin-1-Yl)Methanol
Chemical formula: C5H11NO
CAS Number: 5990-17-6
Synonyms: 1-(Hydroxymethyl)pyrrolidine
Manufacturer: Standard laboratory-grade suppliers
Recommended use: Chemical intermediate, research and development
Restrictions on use: Not for food, drug, household, or cosmetic purposes
Emergency phone: Manufacturer's 24-hour emergency contact

Hazard Identification

Classification: Skin irritation, eye damage, acute toxicity (oral and inhalation)
Signal word: Warning
Hazard statements: Causes skin and eye irritation; harmful if swallowed or inhaled; may cause central nervous system effects
Precautionary statements: Avoid contact with skin, eyes, and clothing; do not ingest or inhale; wash hands thoroughly after handling
GHS pictograms: Exclamation mark
Potential health effects: Shortness of breath, nausea, dizziness, skin and eye redness
Environmental hazards: May cause harm to aquatic life

Composition / Information on Ingredients

Chemical name: L-(Pyrrolidin-1-Yl)Methanol
CAS number: 5990-17-6
Concentration: 97-100% (pure substance)
Impurities: Negligible under certified standard conditions
Additives: None identified
Other components: None expected beyond trace solvent residues

First Aid Measures

Inhalation: Remove person to fresh air; seek medical attention if symptoms persist; provide oxygen if breathing is difficult
Skin contact: Remove contaminated clothing; rinse affected area thoroughly with soap and water; contact physician if irritation develops
Eye contact: Rinse cautiously with water for several minutes holding eyelids open; remove contact lenses if present and easy to do; obtain medical attention for persistent symptoms
Ingestion: Rinse mouth; do not induce vomiting; call poison control or seek medical attention right away
Symptoms requiring immediate care: Shortness of breath, persistent skin/eye pain, confusion, or loss of consciousness

Fire-Fighting Measures

Suitable extinguishing media: Dry chemical, CO2, foam, or water spray
Unsuitable extinguishing media: Strong water jet
Fire hazards: May produce toxic fumes under fire conditions (nitrogen oxides, carbon monoxide)
Protective equipment for firefighters: Self-contained breathing apparatus, full protective clothing
Specific hazards: Vapor accumulation in confined spaces, potential for flashback
Special precautions: Evacuate area; use water spray to cool sealed containers

Accidental Release Measures

Personal precautions: Wear gloves, goggles, and protective clothing to avoid direct exposure
Environmental precautions: Prevent spill from entering drains, surface water, or soil
Containment methods: Absorb with inert material such as sand or diatomaceous earth
Cleanup procedures: Scoop absorbed material into labeled waste containers; clean remnant with detergent and water
Emergency procedures: Evacuate unprotected personnel, ventilate area, control ignition sources

Handling and Storage

Handling: Keep closed; handle in well-ventilated areas; avoid inhalation or contact with skin and eyes; do not eat, drink, or smoke during use
Hygienic practices: Practice good industrial hygiene and safety procedures
Storage conditions: Store in cool, dry, well-ventilated location; temperature range 2–8 °C; keep away from incompatible materials such as oxidizers
Packaging materials: Use chemically resistant containers (glass, polyethylene, PTFE-lined caps)
Incompatibilities: Strong acids, strong bases, oxidizing agents

Exposure Controls and Personal Protection

Exposure limits: No established occupational exposure limits
Engineering controls: Work under local exhaust, chemical fume hood, or in well-ventilated rooms
Personal protective equipment: Chemical-resistant gloves (nitrile recommended), safety goggles or face shield, lab coat
Respiratory protection: Use NIOSH-approved respirator if vapor or aerosol exposure is possible
Environmental exposure controls: Do not discharge into drains; observe local environmental regulations

Physical and Chemical Properties

Appearance: Clear to slightly yellowish liquid
Odor: Weak, amine-like
Boiling point: Approximately 180–185 °C
Melting point: Not well defined (usually remains liquid at room temperature)
Solubility: Mischible with water and common organic solvents (ethanol, acetone)
Density: Around 1.0 g/cm³
pH: Not available (aqueous solutions may be mildly basic)
Vapor pressure: Negligible at ambient temperature
Flash point: Above 80 °C (closed cup)
Auto-ignition temperature: Not determined
Partition coefficient (log Kow): Not established
Viscosity: Low, similar to light alcohols

Stability and Reactivity

Chemical stability: Stable under recommended storage and handling conditions
Reactivity: Does not react vigorously under normal conditions
Hazardous polymerization: Does not occur
Conditions to avoid: Heat, open flames, oxidizing conditions, direct sunlight
Incompatible materials: Strong acids, strong oxidizers, acyl chlorides
Hazardous decomposition products: Carbon monoxide, nitrogen oxides under fire conditions

Toxicological Information

Likely routes of exposure: Skin/eye contact, inhalation, ingestion
Acute toxicity: Harmful if swallowed (estimated LD50 oral - rat: >400 mg/kg), may cause irritation to respiratory tract
Skin corrosion/irritation: Prolonged contact may cause redness and discomfort
Serious eye damage/irritation: Risk of eye irritation, tearing, and redness
Respiratory sensitization: Prolonged or repeated exposure may cause respiratory tract irritation
Carcinogenicity: Not classified as carcinogen (IARC, NTP, OSHA)
Specific target organ toxicity: Possible central nervous system effects with overexposure
Symptoms of overexposure: Headache, dizziness, confusion, nausea
Chronic toxicity: No long-term data available for repeated exposure effects

Ecological Information

Ecotoxicity: Not expected to be highly toxic to aquatic life at low concentrations, but lacks chronic studies
Persistence and degradability: Likely biodegradable in activated sludge and soil environments
Bioaccumulation potential: Low, based on structure and solubility
Mobility in soil: Mobile in water, risk of leaching
Other adverse effects: Limited data suggests slight hazard for groundwater contamination in high-release scenarios

Disposal Considerations

Waste methods: Dispose of in accordance with local, regional, and national regulations; do not pour down the drain or dispose of with household waste
Packaging disposal: Triple-rinse empty containers before discarding as hazardous waste; do not reuse containers
Recommended treatment: Incinerate material at licensed chemical waste facility where permitted; consult applicable environmental authority
Contaminated materials: Manage gloves, wipes, and tools as hazardous laboratory waste

Transport Information

UN Number: Not classified under UN regulations
Shipping name: Not regulated for transport under IMDG, IATA, DOT
Transport hazard class: Non-hazardous for air, sea, and road use under normal handling conditions
Packing group: None assigned
Special precautions: Securely close containers, prevent leaks, and protect from direct sunlight and heat during transport

Regulatory Information

TSCA status: Listed or exempt
REACH status: Registration may be required for European import/export
SARA/Title III: Not subject to reporting under Section 313
California Proposition 65: Not listed
Other regional legislation: Observe applicable local, state, and national chemical regulations
Workplace labeling requirements: Label with product name, hazard warnings, and handling instructions as set by OSHA and GHS
Restrictions: Supplied for research and professional use only; keep out of reach of non-professionals