Product Name: L-Proline
Chemical Formula: C₅H₉NO₂
Synonyms: (S)-Pyrrolidine-2-carboxylic acid, L-(+)-Proline
CAS Number: 147-85-3
Recommended Use: Laboratory chemicals, synthesis of pharmaceutical products, dietary supplements, industrial research
Manufacturer: Information supplied on request from supplier or product label
Emergency Contact: Refer to regional poison center or supplier contact details provided on the product packaging
UN Number: Not classified as hazardous for transport
GHS Classification: Not classified as hazardous according to GHS
Signal Word: None
Hazard Statements: L-Proline usually doesn’t pose hazards under normal handling; dust may irritate respiratory system, eyes, or skin
Pictograms: Not applicable
Precautionary Statements: Avoid producing dust, use ventilation, prevent eye and skin contact, wash hands thoroughly
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Health Effects: Mechanical irritation through dust exposure
Chronic Health Effects: Repeated or prolonged exposure may dry skin or cause mild irritation
Chemical Name: L-Proline
Common Name: L-Proline
CAS Number: 147-85-3
Percent: >99% (purity varies by manufacturer specification)
Impurities/Additives: Typically less than 1% by weight, see supplier certificate for exact amounts
General Advice: Move affected person to fresh air, call for medical help if symptoms appear severe
Inhalation: Remove to fresh air, provide oxygen if indicated, seek medical attention if symptoms persist
Skin Contact: Wash with soap and plenty of water, remove contaminated clothing, consult a physician if irritation develops
Eye Contact: Rinse thoroughly with water for several minutes, remove contact lenses, seek medical help if irritation occurs
Ingestion: Rinse mouth, do not induce vomiting, give water if conscious, seek medical attention if feeling unwell
Symptoms: May include coughing, sneezing, irritation, redness in eyes or skin, sore throat
Suitable Extinguishing Media: Water spray, foam, dry chemical, or carbon dioxide
Unsuitable Extinguishing Media: Strong water jets
Specific Hazards: Combustion produces carbon oxides, nitrogen oxides, may emit toxic fumes
Protective Equipment: Firefighters wear self-contained breathing apparatus and protective suit
Firefighting Procedures: Move containers from fire area if safe, cool containers with water, prevent run-off entering drains
Explosion Data: Dust may create explosion hazard if forming a dust cloud in air under certain conditions
Personal Precautions: Use personal protective equipment, avoid dust formation, ventilate area
Environmental Precautions: Prevent spills from entering drains, soil, and watercourses
Methods for Cleanup: Collect material using shovel or vacuum with HEPA filter, place in labeled container for disposal, wash spill site after cleanup
Emergency Procedures: Follow standard laboratory spill response, evacuate non-essential personnel if necessary, avoid raising dust
Disposal: Dispose of waste in accordance with local regulations; avoid contamination of environment
Handling: Handle with care to avoid dust generation, use proper ventilation, wash hands after handling, avoid eating or drinking in work area, wear suitable gloves and goggles
Storage Conditions: Store in a tightly closed container in a cool, dry, well-ventilated area away from incompatible substances such as strong oxidizing agents
Storage Location: Designated chemical storage area, label shelf securely
Incompatible Materials: Strong acids, strong bases, oxidizers
Hygiene Measures: Maintain good housekeeping, wash thoroughly after use, keep away from food and drink
Exposure Limits: No occupational exposure limits set for L-Proline
Engineering Controls: Use fume hood or adequate ventilation, keep airborne levels below exposure guidelines
Personal Protective Equipment: Safety glasses or goggles, lab coat or apron, powder-resistant gloves (nitrile or latex), dust respirator if forming dust
Hygiene Practices: Remove and wash contaminated clothing, do not eat, drink, or smoke during use, wash hands before meals
Environmental Controls: Use spill catch basins or mats where necessary, monitor exhaust air for particulates if handling in large quantities
Appearance: White to off-white crystalline powder
Odor: Odorless or faint characteristic odor
pH: 5.5–7.0 (10% solution in water)
Melting Point: 220–222 °C (decomposes above melting point)
Boiling Point: Not available
Flash Point: Not applicable
Solubility: Soluble in water, slightly soluble in ethanol, insoluble in ether
Density: 1.35–1.40 g/cm³
Vapor Pressure: Not applicable
Molecular Weight: 115.13 g/mol
Partition Coefficient: Log Kow: -2.54 (estimated)
Auto-Ignition Temperature: Not determined
Chemical Stability: Stable under recommended storage conditions
Reactivity: No dangerous reactions known under normal conditions
Incompatible Materials: Strong oxidizing agents, acids, bases
Hazardous Decomposition Products: Produces carbon oxides and nitrogen oxides when heated or burned
Polymerization: Will not undergo hazardous polymerization
Conditions to Avoid: Moisture, excessive heat, sources of ignition, incompatible materials
Acute Toxicity: Oral LD50 (rat): >5000 mg/kg (practically non-toxic); no data for inhalation or dermal LD50
Skin Corrosion/Irritation: Not classified as irritant; prolonged exposure may cause dryness
Eye Damage/Irritation: May cause mild irritation from dust exposure
Respiratory Sensitization: No data; dusts might cause transient irritation
Carcinogenicity: Not listed by IARC, NTP, OSHA
Reproductive Toxicity: No significant effects documented in animal studies
Mutagenicity: Negative in Ames Test; not considered a mutagen
Other Effects: Large quantities may produce mild gastrointestinal discomfort if ingested
Ecotoxicity: Not harmful to aquatic organisms at expected concentrations; readily biodegradable
Persistence and Degradability: Expected to degrade under environmental conditions, not likely to persist in water or soil
Bioaccumulation Potential: Not expected to bioaccumulate (low partition coefficient)
Mobility: High solubility in water increases mobility in soil and aquatic systems
Aquatic Toxicity: LC50 (fish): Not determined, expected to be >100 mg/L based on similar compounds
Other Adverse Effects: No evidence for long-term hazard in the environment or food chain
Waste Disposal Methods: Dispose of via licensed waste disposal contractors, according to local, regional, national regulations
Contaminated Packaging: Rinse containers with water, send for recycling or disposal as hazardous waste
Landfill: Permitted for non-hazardous household-like quantities, but follow local rules
Incineration: Chemical incinerator equipped with afterburner and scrubber recommended for large-scale disposal
Special Precautions: Avoid discharge into drains or water sources, do not dispose with household garbage, label waste clearly
UN Number: Not regulated for transport
Proper Shipping Name: L-Proline
Transport Hazard Class(es): Non-hazardous
Packing Group: Not assigned
Environmental Hazards: Not a marine pollutant
Special Precautions for Transport: Keep containers tightly sealed and protected from moisture during transit, secure loads to prevent damage
TSCA Status: Listed on the US TSCA Inventory
REACH Registration: Notified or exempted in the EU
DSL/NDSL (Canada): Listed
OSHA Hazards: Not considered hazardous under OSHA Hazard Communication Standard
WHMIS Classification: Not controlled
SARA Title III Sections 311/312: No hazard categories
California Proposition 65: Not listed as a carcinogen or reproductive toxicant
Other International Regulations: Meets requirements for handling, labeling, and documentation in the United States, Canada, European Union, and Asia-Pacific regions
