Product Name: L-4-Hydroxyproline
Synonyms: (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid
Molecular Formula: C5H9NO3
Molecular Weight: 131.13 g/mol
CAS Number: 51-35-4
Recommended Use: Laboratory research, pharmaceutical synthesis, biochemical analysis
Manufacturer Contact: See supplier/distributor for emergency numbers and business contact details
Emergency Telephone: Available through CHEMTREC or local health and safety service
Address: Listed on purchase documents from supplier
Classification: Not classified as hazardous under GHS criteria
Physical Hazards: Not flammable, not explosive, not oxidizing
Health Hazards: Exposure may cause irritation to the eyes, skin, and respiratory tract; ingestion in large amounts may result in discomfort
Environmental Hazards: No evidence for significant environmental toxicity
Warning Symbols: No GHS symbols required
Signal Word: None
Hazard Statements: May cause mild irritation if mishandled during laboratory use
Precautionary Statements: Avoid contact with skin, eyes, and clothing; ensure proper ventilation
Chemical Name: L-4-Hydroxyproline
Synonyms: L-Hydroxyproline, trans-4-Hydroxy-L-proline
CAS Number: 51-35-4
EC Number: 200-095-2
Purity: 98% or greater for laboratory and pharmaceutical use
Impurities: No significant impurities expected in high-grade product
Additives: None indicated for pure substance
Eye Contact: Rinse cautiously with water for at least 15 minutes; remove contact lenses if present and easy to do; seek medical care if symptoms persist
Skin Contact: Wash skin with plenty of soap and water; remove contaminated clothing and shoes; consult physician if irritation develops
Inhalation: Move person to fresh air; restore breathing if affected; seek medical attention for any symptom persistence
Ingestion: Rinse mouth thoroughly with water; do not induce vomiting unless instructed by medical personnel; obtain medical attention
Most Important Symptoms: May include irritation, redness, coughing, or gastrointestinal upset
Immediate Medical Attention: Recommended for known allergy or persistent reactions
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, water spray, foam
Unsuitable Extinguishing Media: None specifically known
Special Hazards: Product does not present unusual fire or explosion hazard; toxic fumes such as carbon oxides and nitrogen oxides might form in fire
Firefighting Procedures: Wear full protective gear and self-contained breathing apparatus for major fires
Combustion Products: May release CO, CO2, nitrogen oxides
Explosion Data: Non-explosive, not prone to dust explosions
Personal Precautions: Use personal protection such as nitrile gloves, goggles, and lab coat
Environmental Precautions: Prevent powder from entering drains or open water
Spill Cleanup Methods: Sweep or vacuum up powder without raising dust; place in appropriate waste containers for disposal
Additional Advice: Wash spill area with water after material pickup
Handling Practices: Avoid breathing dust, minimize contact with skin and eyes, keep containers closed when not in use, use in well-ventilated spaces
Storage Conditions: Store in a cool, dry, well-ventilated area; protect from sunlight and moisture; store in tightly sealed container
Incompatibilities: Strong oxidizing agents, strong acids
Hygienic Practices: Wash hands before eating, drinking, and after work; remove contaminated clothing
Exposure Limits: No occupational exposure limits assigned
Engineering Controls: Use local exhaust or mechanical ventilation to reduce dust exposure
Personal Protective Equipment: Protective gloves (nitrile or latex), safety glasses or goggles, lab coat
Respiratory Protection: Use dust mask or respiratory protection if local exposure risk indicates
Environmental Exposure: Avoid release into the environment, follow best laboratory practices
Appearance: White to off-white crystalline powder
Odor: Slight to no odor
Melting Point: 266–269°C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Soluble in water, sparingly soluble in ethanol
pH: Acidic to neutral in water solution
Vapor Pressure: Not measurable (solid at room temp)
Density: 1.46–1.5 g/cm³
Flash Point: Not flammable
Partition Coefficient: logP = -2.1 (estimated)
Evaporation Rate: Not applicable
Chemical Stability: Stable under recommended handling and storage procedures
Reactivity: No hazardous reactions known under normal use
Incompatible Materials: Strong oxidizing agents, strong acids
Decomposition Products: Releases carbon oxides and nitrogen oxides if exposed to excessive heat or combustion
Polymerization: Does not occur
Conditions to Avoid: Excessive heat, direct sunlight, moisture exposure
Acute Toxicity: Oral LD50 (rat): > 5000 mg/kg; low toxicity expected
Skin Corrosion/Irritation: May cause mild skin irritation on extended contact
Serious Eye Damage/Irritation: Potential for mild irritation, especially in powder form
Respiratory or Skin Sensitization: No evidence for sensitization
Chronic Toxicity: Not classified as carcinogen, mutagen, or reproductive toxin
Ingestion Risk: Large amounts may cause digestive upset
Long-Term Effects: No published reports of chronic effects
Ecotoxicity: Expected to exhibit low aquatic toxicity; no adverse effects observed in typical environmental concentrations
Persistence and Degradability: Readily biodegradable due to amino acid structure
Bioaccumulative Potential: Expected to have low potential for bioaccumulation
Mobility in Soil: Likely to move with water due to good solubility
Other Adverse Effects: Does not deplete ozone, not a persistent organic pollutant
Waste Treatment Methods: Dispose of according to local, regional, and national regulations; usually can be treated as laboratory chemical waste
Contaminated Packaging: Remove residues before recycling or disposal; decontaminate if possible
Disposal Approach: Do not pour into drains or natural watercourses
Recommendation: Use licensed chemical waste disposal facilities
UN Number: Not regulated for transport
Proper Shipping Name: Not assigned (non-hazardous for transport)
Transport Hazard Class: Non-hazardous material
Packing Group: Not assigned
Land Transport ADR/RID: No restrictions
Marine Transport IMDG: Not regulated
Air Transport ICAO/IATA: Not regulated
Special Precautions: Ensure packaging prevents leakage of powder
Safety, Health and Environmental Regulations: Not classified as hazardous under OSHA, WHMIS, or EU CLP regulations
Inventory Listings: Listed on EINECS, TSCA, DSL, ENCS
Label Requirements: No specific hazard pictograms or statements required
REACH Information: Registered or pre-registered
Other Regulations: Not subject to chemical weapons convention, not regulated as a drug or scheduled substance
Workplace Limits: No occupational exposure limits established
