Product Name: Indole
Chemical Formula: C8H7N
Synonyms: 1-Benzopyrrole, Benzopyrrole, Ketole
CAS Number: 120-72-9
Recommended Uses: Laboratory reagent, manufacturing of fragrances and pharmaceuticals
Supplier Information: Contact relevant chemical provider for specific supplier address and phone number
GHS Classification: Acute toxicity (oral, dermal, inhalation), Eye irritation, Skin irritation
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin irritation, causes serious eye irritation, toxic to aquatic life
Pictograms: Exclamation mark, environment
Precautionary Statements: Avoid inhalation of dust or vapor, wear protective gloves and eye protection, avoid release to the environment
Chemical Name: Indole
Concentration: Greater than 99%
Impurities: Trace residual organic contaminants found in minor concentrations depending on synthesis batch
Inhalation: Move person to fresh air, seek medical attention if symptoms persist
Skin Contact: Wash skin immediately with soap and water, remove contaminated clothing
Eye Contact: Rinse eyes thoroughly with water for several minutes, remove contact lenses if present
Ingestion: Rinse mouth, do not induce vomiting, call poison control center or doctor for advice
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, water spray
Unsuitable Extinguishing Media: High-pressure water jet may spread fire
Specific Hazards: Vapors may form explosive mixtures with air, may release toxic fumes of nitrogen oxides and carbon monoxide when burned
Protective Equipment: Firefighters should use self-contained breathing apparatus and full protective clothing
Personal Precautions: Evacuate area, ensure adequate ventilation, avoid breathing vapors, wear protective equipment
Environmental Precautions: Prevent entry into drains or water systems, contain spill using non-combustible absorbent material
Cleanup Methods: Collect and place in appropriate sealed disposal containers, decontaminate surfaces with suitable detergent, dispose of waste according to regulations
Handling: Handle in a well-ventilated area, avoid contact with skin and eyes, prevent formation of dust or aerosols
Storage: Store in tightly closed containers, keep in a cool, dry, well-ventilated place away from incompatible materials such as oxidizers, acids, and strong bases
Incompatible Materials: Strong oxidizing agents, strong acids and bases
Engineering Controls: Use fume hood or local exhaust ventilation to minimize exposure
Personal Protective Equipment: Protective gloves (nitrile or neoprene), safety goggles, laboratory coat, appropriate respiratory protection for poorly ventilated areas
Exposure Limits: No occupational exposure limits established by OSHA, ACGIH, or NIOSH; minimize exposure as a precaution
Appearance: White to light brown crystalline powder
Odor: Fecal, intense, often compared to mothballs or jasmine
Melting Point: 52-54 °C
Boiling Point: 253 °C
Flash Point: 120 °C
Solubility: Slightly soluble in water, soluble in ethanol, ether, hot oils
Vapor Pressure: 0.016 mmHg at 25 °C
Density: 1.22 g/cm³ at 20 °C
pH: Not applicable
Auto-Ignition Temperature: 480 °C
Chemical Stability: Stable under recommended storage conditions
Reactivity: Not highly reactive, but reacts with strong oxidizing agents
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide upon combustion
Polymerization: Not known to polymerize under normal conditions
Conditions to Avoid: Heat, sources of ignition, incompatible materials
Acute Toxicity: Oral LD50 (rat) 1000 mg/kg, harmful in large quantities
Skin Irritation: Causes irritation with possible redness or blistering
Eye Irritation: Severe irritation, redness, watering
Respiratory Effects: Inhalation may cause headache, nausea, and respiratory irritation
Chronic Effects: Prolonged exposure may cause damage to lungs, liver, or kidneys; repeated contact can increase sensitivity
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA
Mutagenicity: No relevant data found
Reproductive Toxicity: Not reported in humans or laboratory animals
Ecotoxicity: Toxic to aquatic life with long lasting effects; data show LC50 (fish) 7 mg/L (96 hr)
Mobility: Moderately mobile in soil, possibility of entering groundwater
Persistence and Degradability: Not readily biodegradable, can persist in water and soil
Bioaccumulation: Potential for bioaccumulation in aquatic organisms
Other Hazards: Avoid contamination of natural water bodies, high concentrations may negatively impact microorganisms and plants
Waste Disposal: Collect material in tightly sealed containers, label clearly, dispose through certified hazardous waste disposal contractor
Contaminated Packaging: Decontaminate before reuse or dispose as hazardous waste
Sewage Disposal: Do not release into the environment, including sewers and drains
Recommended Methods: High-temperature incineration with approved air pollution controls, follow all local, state, and federal regulations regarding disposal
UN Number: 2811
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Marine Pollutant: Yes
DOT Proper Shipping Name: Toxic solid, organic, n.o.s. (contains Indole)
Special Precautions: Secure containers, provide documentation of hazard class and emergency measures, avoid temperature extremes and physical damage during transit
TSCA Listing: Listed on U.S. Toxic Substances Control Act (TSCA) inventory
SARA Title III: Not specifically listed under Sections 302, 304, or 313
OSHA: No PEL established
EU Regulations: Registered under REACH, subject to restrictions concerning environmental release
Other International Regulations: Check local and national regulations for labeling, waste, and storage; requirements may differ between jurisdictions, including labeling for aquatic toxicity and protective measures
