Product Name: Imidazole
Chemical Formula: C3H4N2
Chemical Family: Heterocyclic aromatic amine
Synonyms: 1,3-Diazole, Glyoxaline
CAS Number: 288-32-4
Recommended Use: Chemical synthesis, pharmaceutical intermediate, laboratory reagent
Manufacturer/Supplier Details: Name, address, and emergency contact number must be accessed on the packaging or supplier documentation.
Emergency Phone: Local poison control center, fire department, or manufacturer’s emergency service number.
GHS Classification: Acute toxicity (oral, dermal, inhalation), skin irritation, eye irritation, respiratory system hazard.
Signal Word: Warning
Hazard Statements: Toxic if swallowed, may irritate skin, causes severe eye irritation, may cause respiratory discomfort.
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, keep container tightly closed.
Pictograms: Exclamation mark, health hazard.
Other Hazards: Can form explosive dust-air mixtures if powdered, flammable under high temperature.
Chemical Name: Imidazole
Concentration: 99 – 100% (varies by supplier)
CAS Number: 288-32-4
Impurities/Additives: Trace levels of related di- and tri-imidazoles possible, depending on synthesis route.
Inhalation: Remove affected person to fresh air, seek medical attention for any breathing discomfort or persistent cough.
Skin Contact: Wash exposed area thoroughly with soap and water, remove contaminated clothing, consult a doctor for persistent irritation.
Eye Contact: Rinse eyes immediately with clean water for at least 15 minutes, lifting eyelids occasionally, seek medical help fast.
Ingestion: Do not induce vomiting, rinse mouth carefully with water, contact a doctor or poison control center at once.
Most Important Symptoms: Burning sensation in eyes, redness or irritation on skin, coughing, headache.
Note To Physician: Treat symptomatically, monitor for delayed respiratory effects.
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, or water spray.
Unsuitable Media: Avoid direct water stream on burning powder.
Fire Hazards: Emits toxic fumes of nitrogen oxides and carbon monoxide under fire conditions.
Protective Equipment For Firefighters: Full protective clothing, self-contained breathing apparatus recommended.
Special Precautions: Move containers from fire area if safe, stay upwind, cool containers exposed to flame with water spray.
Combustion Products: Potential release of volatile organics, cyanides, and smoke under incomplete combustion.
Personal Protection: Wear protective gloves, safety goggles, lab coat, and dust mask or respirator.
Environmental Precautions: Prevent entry of spilled material into drains, waterways, or soil.
Spill Cleanup Methods: Sweep up spilled powder, collect in closed container for disposal, ventilate area.
Decontamination: Wash spill area thoroughly with water and detergent after removal.
Emergency Procedures: Alert local emergency response if large release, evacuate area as necessary.
Safe Handling Guidelines: Avoid inhalation and physical contact, keep away from food or drinks, use in well-ventilated spaces.
Storage Conditions: Store in tightly closed container, in cool, dry, well-ventilated area away from ignition sources.
Incompatibilities: Avoid oxidizers, acids, and halogenated compounds.
Technical Measures: Ground and bond equipment when transferring powdered product.
Hygiene Recommendations: Wash hands before eating, drinking, or using restroom after handling.
Permissible Exposure Limit (PEL): No established OSHA or ACGIH limits as of last review.
Engineering Controls: Use local exhaust ventilation, enclosed handling systems for powders.
Personal Protective Equipment (PPE): Chemical-resistant gloves, splash goggles, lab coats, dust masks.
Respiratory Protection: Use NIOSH-approved respirator in absence of adequate ventilation or with large releases.
Skin Protection: Impervious clothing and gloves prevent repeated or prolonged skin contact.
Eye Protection: Chemical splash goggles or face shield protect against irritation and splash.
Appearance: White to slightly off-white crystalline solid.
Odor: Mild, characteristic amine-like smell.
Molecular Weight: 68.08 g/mol
Melting Point: 89 – 91°C
Boiling Point: 256°C at 760 mmHg
Solubility: Soluble in water, alcohol, and chloroform.
pH (1% Solution): 10.0 – 11.0
Vapor Pressure: 0.0022 mmHg at 25°C
Flash Point: 145°C (Closed cup)
Density: 1.03 g/cm³ at 20°C
Partition Coefficient (log Pow): -0.02 (low potential for bioaccumulation).
Evaporation Rate: Not volatile at room temperature.
Autoignition Temperature: 570°C
Chemical Stability: Stable under recommended handling and storage conditions.
Hazardous Reactions: Reacts vigorously with strong oxidizers, acids.
Hazardous Decomposition Products: Nitrogen oxides, cyanides, hydrogen cyanide gas (at high temperature).
Conditions To Avoid: High humidity, elevated temperatures, ignition sources, incompatible substances.
Polymerization: Not known to occur under normal conditions.
Likely Routes of Exposure: Inhalation, skin and eye contact, ingestion.
Acute Toxicity: Oral LD50 (rat): 970 mg/kg, Dermal LD50: >2000 mg/kg (rabbit).
Chronic Effects: No sufficient evidence of carcinogenicity in humans, possible skin sensitizer.
Symptoms of Overexposure: Drowsiness, headache, nausea, skin redness, severe eye discomfort.
Mutagenicity/Teratogenicity: No conclusive lab studies indicating mutagenic or teratogenic risk, handle prudently.
Reproductive Toxicity: No available data supporting reproductive hazard.
Other Data: Prolonged inhalation at high levels shows mild effect on rodents in controlled lab exposure.
Aquatic Toxicity: Harmful to aquatic organisms in high concentrations, LC50 (96h, Fish) >500 mg/L.
Persistence/Degradability: Readily biodegradable by soil and aquatic microbes under normal environmental conditions.
Bioaccumulation: Low potential due to low partition coefficient.
Mobility In Soil: Moves freely in soil, risk for groundwater contamination with large spills.
Other Ecological Effects: Not expected to persist in environment or bioaccumulate in food chains at normal exposure levels.
Waste Disposal Method: Collect in sealed, labeled containers, incinerate in licensed facility for organic chemicals.
Contaminated Packaging: Rinse empty containers thoroughly, dispose of per local hazardous waste regulations.
Special Notes: Do not allow material to enter public sewers or natural water sources.
Disposal Regulations: Comply with national or local environmental regulations regarding hazardous laboratory chemicals.
UN Number: Not regulated as hazardous for ground or air transport in most jurisdictions.
Proper Shipping Name: Imidazole, not otherwise specified.
Transport Hazard Class: Not classified as dangerous goods by DOT, IATA, or IMDG.
Packing Group: Not assigned.
Special Precautions: Keep packages tightly closed, avoid breakage, label as chemical for laboratory use.
TSCA Status: Listed in United States TSCA Inventory.
REACH Registration: Registered substance in EU with appropriate safety assessment.
SARA Title III: Not subject to reporting under sections 302, 304, 312, 313.
OSHA: Not specifically regulated as hazardous substance.
WHMIS (Canada): Classified as hazardous, D2B (Toxic materials causing other toxic effects).
Other Regulatory Details: Not listed by IARC, NTP, or ACGIH as a suspected carcinogen. Users should confirm regulatory compliance based on intended use and geographic location.
