Product Name: L-Histidine
Chemical Formula: C6H9N3O2
Chemical Family: Amino acid
CAS Number: 71-00-1
EC Number: 200-745-3
Synonyms: His, (S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid
Recommended Use: Laboratory reagent, research chemical, dietary supplement manufacturing, pharmaceutical applications
Supplier: Chemical distributors or manufacturers, listed with address and emergency contact phone number
Potential Hazards: Slightly hazardous in case of ingestion or eye contact, may cause mild irritation to eyes, mucous membranes or skin upon prolonged contact
GHS Classification: Not classified as hazardous under GHS criteria
Pictogram: Not applicable
Signal Word: Not applicable
Hazard Statements: Not considered hazardous under normal workplace conditions
Precautionary Statements: Avoid prolonged inhalation or repeated skin contact; wash skin after handling
Chemical Name: L-Histidine
Concentration: >99%
CAS Number: 71-00-1
Impurities: Trace inorganic salts, water
Other Identifiers: EINECS: 200-745-3
Inhalation: Move exposed person to fresh air, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, wash skin with soap and water, seek medical evaluation if irritation develops
Eye Contact: Rinse eyes with plenty of water for several minutes, lift eyelids to ensure thorough irrigation, obtain medical aid if irritation continues
Ingestion: Rinse mouth, drink water, do not induce vomiting, seek immediate medical attention if feeling unwell
Most Important Symptoms/Effects: Mild irritation of eyes, skin, respiratory tract if exposed to large quantities
Suitable Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide as appropriate for surrounding materials
Unsuitable Extinguishing Media: Avoid high-pressure water jet
Specific Hazards: Emits nitrogen oxides, carbon monoxide and carbon dioxide under fire conditions
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear
Special Procedures: Prevent firewater runoff from entering drains or water sources, use water spray to cool fire-exposed containers
Thermal Decomposition: Decomposes when heated to give toxic fumes of nitrogen oxides and carbon oxides
Personal Precautions: Use proper personal protective equipment including gloves and goggles to avoid contact
Environmental Precautions: Prevent entry into sewers, basements, or confined spaces; minimize dust formation, ventilate area
Methods for Clean Up: Sweep up or vacuum spill carefully, avoid generating dust, place in suitable closed container for disposal; wash spill site after complete pick up
Handling: Minimize dust generation, avoid ingestion and inhalation, use good laboratory practice, avoid contact with skin and eyes, handle in well ventilated area
Storage Conditions: Store in tightly closed original container, in a cool, dry and well-ventilated place, away from incompatible materials such as oxidizing agents and acids
Maximum Storage Temperature: Ambient or below 25°C
Recommended Shelf Life: Refer to manufacturer's information for expiry date; protect from moisture and light
Handling Advice: Keep away from food, beverages, and animal feeds; do not smoke, drink, or eat during use
Engineering Controls: Work in a chemical fume hood or well-ventilated area; maintain good industrial hygiene practices
Control Parameters: No established occupational exposure limits for histidine, monitor for nuisance dust
Personal Protection: Wear protective gloves made of nitrile or compatible material, chemical splash goggles, laboratory coat or apron
Respiratory Protection: Use dust masks (N95 or equivalent) if dust generation likely
Thermal Hazards: Not applicable under normal use
Hygiene Measures: Wash skin after handling, remove contaminated clothing and wash before reuse
Appearance: White to off-white crystalline powder
Odor: Odorless
Molecular Weight: 155.15 g/mol
pH (1% solution): Approximately 7.0
Melting Point: Decomposes above 287°C
Solubility: Soluble in water, insoluble in ethanol and ether
Vapor Pressure: Not applicable for solid
Density: About 1.59 g/cm³
Partition Coefficient (log Kow): -3.32
Autoignition Temperature: Not determined
Upper/Lower Flammability: Not flammable
Evaporation Rate: Not applicable
Boiling Point: Not applicable, decomposes
Chemical Stability: Stable under recommended storage temperature and conditions
Reactivity: No dangerous reactions known under normal conditions
Hazardous Reactions: Will not polymerize, avoid strong oxidizing agents and acids to prevent decomposition
Incompatible Materials: Strong oxidizers, strong acids
Decomposition Products: Nitrogen oxides, carbon oxides upon thermal decomposition
Conditions to Avoid: Heat, moisture, direct sunlight, sources of ignition
Acute Toxicity (Oral): Estimated to be low based on animal data, LD50 (rat) > 5000 mg/kg
Skin Corrosion/Irritation: Mild, non-corrosive, may cause slight irritation
Eye Damage/Irritation: Slight irritant
Respiratory Sensitization: Dust can cause mild respiratory tract irritation
Carcinogenicity: Not listed by IARC, NTP, OSHA
Reproductive/Developmental Toxicity: Not classified as toxic for reproduction, data not available for significant risks in humans
Mutagenicity: No evidence seen in standard in vitro and animal studies
Chronic Toxicity: No adverse chronic effects noted from normal laboratory practices
Ecotoxicity: Based on structural properties and natural occurrence, not expected to pose a significant risk to aquatic or terrestrial environments
Persistence and Degradability: Readily biodegradable, broken down by soil and aquatic microorganisms
Bioaccumulative Potential: Very low, log Kow indicates no risk for bioaccumulation
Mobility in Soil: High solubility in water, mobile in soil and groundwater
Other Adverse Effects: None known, does not meet criteria for persistent, bioaccumulative, or toxic substance
Waste Treatment Methods: Collect waste in suitable labelled containers, dispose of as non-hazardous chemical waste per local and national regulations
Contaminated Packaging: Dispose as non-hazardous laboratory waste if emptied and rinsed, otherwise treat as chemical waste
Special Precautions: Do not discharge to sewers or waterways, avoid contamination of groundwater
UN Number: Not regulated by UN as a hazardous good
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not classified
Packing Group: Not applicable
Environmental Hazards: None
Special Transport Precautions: Keep container tightly closed, protect from moisture, transport in accordance with good chemical hygiene practices
US Regulations: SARA 302: Not listed, SARA 313: Not listed, TSCA: Listed, OSHA Hazard Communication: Not hazardous
EU Regulations: REACH: Exempt as a natural amino acid, not classified as dangerous
Japan: Listed on ENCS
Canada: DSL/NDSL: Listed
Other Information: Not subject to chemical safety assessment under global chemical regulations, labeling not required beyond basic workplace labelling practices
