Product Name: Fluphenazine
Chemical Name: 10-[3-[2-(Trifluoromethyl)phenothiazin-10-yl]propyl]-2-piperazineethanol
CAS Number: 69-23-8
Synonyms: Prolixin, Modecate, Fluphenazine dihydrochloride, Fluphenazine decanoate
Intended Use: Antipsychotic agent for clinical, laboratory, or pharmaceutical research applications
Manufacturer Details: [Insert Manufacturer Name, Address, Contact Information]
Emergency Number: [Insert Emergency Contact Number]
Hazard Classification: Acute oral and dermal toxicity, organ toxicity, central nervous system effects
GHS Label Elements: Signal Word: Warning; Hazard Pictograms: Health hazard symbol
Possible Effects: Causes central nervous system depression, potential organ toxicity with repeated exposure, risk of allergic reactions
Routes of Entry: Inhalation, ingestion, skin contact, eye contact
Carcinogenic Status: No classification under US NTP, IARC, OSHA
Emergency Overview: White to yellowish crystalline powder, may cause respiratory and dermal irritation
Chemical: Fluphenazine
CAS Number: 69-23-8
Concentration (Active Ingredient): Typically 98–100% for research grade samples
Impurities: Trace solvents and manufacturing byproducts may be present in minor quantities
Other Ingredients: None in pure substance; formulated products may contain stabilizers or excipients
Inhalation: Move outdoors for fresh air. Keep person calm and monitor for breathing difficulties. Seek medical help if symptoms carry on.
Skin Contact: Remove contaminated clothing, rinse affected skin with copious water and mild soap. Get medical attention for persistent irritation.
Eye Contact: Flush open eyes with clean water for 15 minutes; lift eyelids; prompt doctor consultation clears risk.
Ingestion: If swallowed, rinse mouth with water immediately. Do not induce vomiting. Seek medical assessment and provide product label.
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical or foam extinguishers
Unusual Hazards: Produces toxic fumes (nitrogen oxides, sulfur oxides, hydrogen chloride, hydrogen fluoride, carbon monoxide) when burning
Special Protective Equipment: Use self-contained breathing apparatus and full protective gear.
Fire-Fighting Instructions: Stay upwind, avoid smoke exposure, cool containers exposed to fire with water spray to prevent explosion hazard.
Personal Precautions: Wear gloves, protective eyewear, lab coat, and a dust mask or respirator designed for chemical powders.
Environmental Precautions: Prevent spilled material from entering drains, surface water, and soil.
Clean-Up Methods: Gently sweep up or vacuum solid (avoid dust), place in sealed container for chemical disposal; wash spill site with water.
Decontamination: Ventilate affected area well and clean all contaminated surfaces thoroughly.
Handling: Avoid inhaling dust; minimize direct skin and eye contact. Do not eat or drink near working area. Use fume hood if dust present.
Storage: Store tightly sealed in cool, dry, and well-ventilated facility. Keep away from ignition sources, oxidizers, acids, and moisture.
Incompatibilities: Strong oxidizing agents, acids, bases
Storage Temperature: Generally 2–8°C; protect from light and heat extremes.
Control Parameters: No OSHA PEL specific to Fluphenazine. NIOSH REL: none established; handle with caution.
Engineering Controls: Fume hood or effective local exhaust for powder handling; closed systems preferred.
Respiratory Protection: NIOSH-approved dust mask/respirator when airborne particles exist.
Skin Protection: Chemical-resistant gloves (nitrile or latex), long sleeves, lab coat
Eye Protection: Tight-fitting safety goggles or face shield
Hygiene Measures: Wash hands thoroughly after use, remove contaminated clothing promptly.
Appearance: White to pale yellow crystalline powder
Odor: Odorless
Molecular Weight: 437.52 g/mol
Melting Point: 172–174°C
Solubility: Slightly soluble in water, soluble in alcohol and chloroform
Vapor Pressure: Not significant at room temperature
pH (in solution): Neutral to weakly acidic
Flash Point: Data not readily available
Partition Coefficient (log Pow): Approximately 3.8
Chemical Stability: Stable under standard temperatures and dry conditions
Hazardous Reactions: No hazardous polymerization
Incompatible Materials: Strong acids, bases, oxidizers
Decomposition Products: Toxic fumes including CO, CO₂, NOₓ, SOₓ, HF, HCl upon burning
Conditions to Avoid: Excess heat, light, humidity, open flame
Acute Toxicity: LD50 (oral, rat): ~31 mg/kg; LD50 (intraperitoneal, mouse): ~35 mg/kg
Local Effects: Skin and eye irritant potential
Chronic Exposure: Risk of tardive dyskinesia and neuroleptic malignant syndrome with prolonged or high dose exposure
Health Hazards: May cause drowsiness, tremors, changes in blood cell counts, liver dysfunction, arrhythmias
Sensitization: Allergic skin and respiratory reactions reported in sensitive individuals
Mutagenicity/Carcinogenicity: Data insufficient for precise assessment, not flagged by IARC or NTP as carcinogen
Environmental Toxicity: Not well characterized; contains halogenated groups, suggesting persistence and bioaccumulation risk
Mobility: Likely adsorbed onto soil particles, limited mobility
Degradability: Not rapidly biodegradable, potential for environmental accumulation
Aquatic Toxicity: Likely toxic to aquatic organisms due to phenothiazine structure
Other Risks: Long-term risk to aquatic and terrestrial environments remains insufficiently evaluated
Disposal Method: Incinerate under controlled conditions or send to approved hazardous waste treatment facility
Packaging: Use sealed containers resistant to powder leakage and chemical corrosion
Waste Code: Check local, state, federal guidelines for pharmaceutical hazardous waste classification
Environmental Precautions: Avoid release to drains, surface waters, and soil; observe all local disposal regulations.
UN Number: Not assigned for Fluphenazine in non-commercial quantities
Transport Hazard Class: Not classified as dangerous for transport under standard regulations
Packing Group: Not applicable
Special Precautions: Keep container tightly closed; avoid temperature extremes; label packages clearly for identification; restrict public access during shipment
Regulatory Notes: Packaging and transport arrangements should align with national pharmaceutical and hazardous material statutes.
OSHA: Not specifically regulated
EPA: Not classified under RCRA, but local waste codes apply
TSCA: Listed substance
REACH (EU): Chemical registration may be required for production/importation >1 ton/year
SARA: Not listed under SARA Title III sections
Other Local Regulations: Subject to state, provincial, and national chemical safety requirements; consult authorities for compliance on use, storage, disposal, and shipment.
