Product Name: Fluphenazine Hydrochloride
Chemical Name: 2-[4-[3-(2-Trifluoromethylphenothiazin-10-yl)propyl]piperazin-1-yl]ethanol dihydrochloride
Synonyms: Fluphenazine HCl, Prolixin Hydrochloride
CAS Number: 146-56-5
Recommended Use: Pharmaceutical ingredient, antipsychotic
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Emergency Contact: [Insert emergency contact number]
Classification: Harmful if swallowed, May cause skin and eye irritation, Risk of respiratory irritation
Hazard Symbols: Xn (Harmful), Xi (Irritant)
Signal Word: Warning
Hazard Statements: H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation)
Precautionary Statements: Avoid inhalation of dust or particles, Avoid direct contact with skin or eyes, Keep away from food and drink
Other Hazards: May cause central nervous system effects, Not considered a combustible dust but may pose health risks if handled carelessly
Chemical Component: Fluphenazine Hydrochloride
Concentration: >98%
Impurities: Pharmaceutical grade, trace residuals within regulatory limits
Molecular Formula: C22H26Cl2F3N3OS
Molecular Weight: 510.43 g/mol
Inhalation: Move to fresh air, support breathing, get medical attention if symptoms develop including shortness of breath, coughing, or dizziness
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing; see a doctor if irritation persists, signs include redness and discomfort
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses, seek medical advice if irritation develops, symptoms include pain and redness
Ingestion: Rinse mouth, never give anything by mouth to an unconscious person, seek medical attention immediately; symptoms after ingestion may include nausea, drowsiness, confusion, or more serious central nervous system effects
Suitable Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide
Special Fire Hazards: Emits toxic fumes under fire conditions including nitrogen oxides, sulfur oxides, hydrogen chloride, and fluorinated compounds
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear
Advice for Firefighters: Stay upwind, avoid inhaling vapors and combustion products, cool containers exposed to flames with water spray
Personal Precautions: Evacuate area, use personal protective equipment including gloves, goggles, and masks
Environmental Precautions: Prevent further leakage or spillage, avoid entry into drains and natural waterways
Methods for Cleaning Up: Scoop up and place in a suitable closed container for disposal; avoid creating dust, ventilate the area, decontaminate surface with detergent and water
Precautions for Safe Handling: Handle in well-ventilated area, wear protective gear including lab coat and gloves, avoid breathing dust, practice good industrial hygiene
Storage Conditions: Store in tightly sealed containers, away from incompatible substances such as strong acids and oxidizing agents, keep in a cool, dry place away from light and moisture
Other Requirements: Keep container upright, ensure containers are labeled, maintain secure storage to avoid unauthorized use, wash hands after handling
Control Parameters: Occupational exposure limits not established for this specific compound
Engineering Controls: Use fume hood, local exhaust ventilation, and safety shower/eye-wash stations in case of severe exposure risk
Personal Protective Equipment: Chemical-resistant gloves, safety goggles or face shield, lab coat, certified respirator if dust levels exceed recommended guidelines
Hygiene Measures: Wash hands after use, change and launder contaminated clothing regularly, refrain from eating, drinking, or smoking in the work area
Appearance: White to off-white crystalline powder
Odor: Odorless or faint chemical smell
Odor Threshold: Not available
pH: 4.0–5.0 (1% solution in water)
Melting Point: About 196–198°C
Boiling Point: Decomposes without boiling
Solubility: Soluble in water and alcohol
Vapor Pressure: Not applicable (solid)
Density: About 1.4 g/cm³
Partition Coefficient (Log Kow): Not determined for hydrochloride salt
Viscosity: Not applicable
Decomposition Temperature: Above 200°C
Chemical Stability: Stable under recommended handling and storage conditions
Reactivity: Not expected to react rapidly with air or water
Incompatible Materials: Strong oxidizing agents, strong acids
Hazardous Decomposition Products: Can release hydrogen chloride, sulfur oxides, nitrogen oxides, and fluorinated compounds under combustion
Conditions to Avoid: Excessive moisture, direct light, strong heat, and open flame
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Effects: Possible nausea, headache, drowsiness, skin and eye irritation, respiratory discomfort
Chronic Effects: Prolonged exposure may cause nervous system effects such as tardive dyskinesia or extrapyramidal symptoms; repeated handling increases risk for those with preexisting health conditions
LD50 (Oral, Rat): 126 mg/kg
Symptoms of Overexposure: Confusion, muscle rigidity, salivation, restlessness, agitation
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, or OSHA; caution due to absence of long-term exposure studies
Ecotoxicity: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Not rapidly biodegradable, may persist in soil and water
Bioaccumulation: Limited data, possible risk of accumulation in sediment and aquatic life
Mobility in Soil: Tends to bind with organic content in soil, reducing mobility
Other Hazards: Take care to minimize environmental release, follow strict waste disposal guidelines to prevent bioaccumulation in local waterways
Waste Treatment Methods: Material should be disposed of as hazardous waste in accordance with local, state, and federal regulations, do not discharge into drains or environment
Container Disposal: Triple rinse containers, puncture to prevent reuse, handle as hazardous material
Precautions: Seek guidance from a licensed waste disposal contractor, prevent accidental release into the environment during disposal steps
UN Number: Not regulated under UN transport rules for hazardous goods
UN Proper Shipping Name: Fluphenazine Hydrochloride
Transport Hazard Class: Not assigned
Packing Group: Not applicable
Marine Pollutant: No data to indicate marine pollutant status, but take precautions to prevent release
Special Precautions for Transport: Transport in secure, clearly labeled containers; avoid exposure to extreme temperatures or contamination with incompatible substances
OSHA Status: Not specifically regulated under OSHA hazardous chemicals list, handle per general chemical safety protocols
TSCA Inventory: Listed
SARA 313: Not subject to SARA Title III, Section 313 reporting
California Proposition 65: Not listed
WHMIS Classification (Canada): D2B – Toxic material causing other toxic effects
Other National Regulations: Ensure handling and disposal follow local environmental and health safety regulations; pharmacists and handlers must comply with prescription drug standards and occupational health guidance
