Material Safety Data Sheet: Ethyl Piperidine-3-Carboxylate

Identification

Product Name: Ethyl Piperidine-3-Carboxylate
Synonyms: 1-Ethoxycarbonyl-3-piperidine
Chemical Formula: C8H15NO2
CAS Number: 1127-87-9
Recommended Uses: Laboratory chemical synthesis, pharmaceutical intermediate
Supplier Details: Manufacturer name, address, phone, emergency contact
Emergency Phone Number: Refer to local and national emergency numbers

Hazard Identification

GHS Classification: Acute toxicity (oral and dermal), irritation to eye and skin
Signal Word: Warning
Hazard Statements: Harmful if swallowed or in contact with skin, causes eye and skin irritation
Pictograms: Exclamation mark symbol
Precautionary Statements: Wear protective gloves, use eye protection, do not eat or drink while handling, avoid inhalation of dust or vapor
Potential Health Effects: Headache, nausea, dizziness, possible skin rash after direct contact
Environmental Effects: May cause harm to aquatic life if large quantities enter watercourses

Composition / Information on Ingredients

Chemical Name: Ethyl Piperidine-3-Carboxylate
Concentration: 98%–100%
Impurities: Trace residual solvents, unreacted starting materials (typically less than 2%)
Chemical Family: Piperidine carboxylic acid ester derivatives
Molecular Weight: 157.21 g/mol

First Aid Measures

Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; keep rinsing
Skin Contact: Wash with plenty of soap and water; remove contaminated clothing; seek medical attention if irritation occurs
Inhalation: Move person to fresh air; monitor for respiratory symptoms such as cough or difficulty breathing; call a physician if symptoms persist
Ingestion: Rinse mouth thoroughly; never give anything by mouth to an unconscious person; seek medical care
Most Important Symptoms: Local irritation, stomach upset, dizziness, headache

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Unsuitable Extinguishing Media: High pressure water stream could spread chemical
Fire Hazards: Combustion could produce nitrogen oxides, carbon oxides, and irritating fumes
Protective Equipment: Wear self-contained breathing apparatus, chemical protection suit
Advice for Firefighters: Cool containers with water spray; prevent runoff from entering drains; evacuate area if necessary

Accidental Release Measures

Personal Precautions: Put on gloves and protective eyewear before handling; ventilate area well
Environmental Precautions: Prevent spill from entering soil, drains, and watercourses
Methods for Cleanup: Absorb spill with inert material such as sand; collect in sealed containers for proper disposal
Other Precautions: Wash area with plenty of water after material is collected; avoid creating dust or aerosols

Handling and Storage

Precautions for Safe Handling: Use in a well-ventilated place, minimize exposure by using local exhaust; avoid breathing vapors or dust; no eating or drinking during work
Storage Conditions: Store tightly closed in a cool, dry, well-ventilated area; keep away from incompatible materials like strong oxidizers and acids
Incompatible Materials: Strong acids, bases, oxidizers
Technical Measures: Use explosion-proof equipment for transferring large volumes; ground equipment against static discharges

Exposure Controls and Personal Protection

Engineering Controls: Work with chemical fume hood or in ventilated space; regularly check air quality in working area
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), splash-proof goggles, long-sleeved lab coat
Respiratory Protection: If dust, vapor, or mist may be formed, use approved respirator
Hygiene Measures: Wash hands and exposed skin before breaks and after work; do not touch face or eat while handling

Physical and Chemical Properties

Appearance: Colorless to pale yellow liquid
Odor: Slight, amine-like
Odor Threshold: Not established
pH: Not available
Melting Point: Data not readily available
Boiling Point: 236–238°C at 760 mmHg
Flash Point: >100°C
Evaporation Rate: Not known
Flammability: May form combustible mixtures at elevated temperatures
Vapor Pressure: Low (data not specified)
Vapor Density: Not established
Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol or acetone
Partition Coefficient (n-octanol/water): Not available
Auto-ignition Temperature: Data not established
Decomposition Temperature: Not specified
Viscosity: Not measured for this compound

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions and temperatures
Possibility of Hazardous Reactions: No hazardous polymerization under standard laboratory conditions
Conditions to Avoid: Ignition sources, strong heat, prolonged exposure to air
Incompatible Materials: Strong oxidizing agents, strong acids or bases
Decomposition Products: Can include carbon oxides, nitrogen oxides, and irritating organic vapors when burned or decomposed

Toxicological Information

Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity (oral, rat): LD50 values not published but chemical may cause moderate harm
Irritation: Causes temporary redness and swelling in eyes and skin
Sensitization: No data available; avoid repeated exposure
Chronic Effects: Repeated or prolonged contact could cause dermatitis, headache, dizziness
Carcinogenicity: Not listed as probable or confirmed carcinogen (IARC, NTP, OSHA)
Mutagenicity: No mutagenic effects observed in standard laboratory tests
Other Data: Individuals with underlying skin or respiratory conditions could be at greater risk

Ecological Information

Toxicity to Aquatic Life: Harmful at high concentrations to aquatic organisms
Persistence and Degradability: Expected to be biodegradable, persistence unlikely under normal environmental conditions
Bioaccumulative Potential: Low bioaccumulation anticipated
Mobility in Soil: May migrate in water, relatively low sorption to sediments
Other Adverse Effects: Spills into watercourses can temporarily disrupt microbial activities and small aquatic animal life

Disposal Considerations

Product Disposal: Send to licensed chemical disposal facility following local, regional, and national regulations
Container Disposal: Clean empty containers with copious water, dispose through chemical waste incineration
Special Precautions: Do not pour down drain or release to environment; document all disposals in waste log

Transport Information

UN Number: Not classified as hazardous under UN transport rules
Proper Shipping Name: Ethyl Piperidine-3-Carboxylate
Transport Hazard Class: Not regulated for ground, air, or sea
Packing Group: Not applicable
Marine Pollutant: Not classified as a marine pollutant
Special Precautions: Keep package tightly sealed and protected from direct sunlight or physical damage during transport

Regulatory Information

Labeling: GHS-compliant hazard label required for packaging
Inventory Status: Listed or exempt in most chemical inventories (TSCA, REACH, DSL, AICS, ENCS)
Workplace Controls: Subject to OSHA laboratory safety standard (29 CFR 1910.1450), European Union REACH regulations
Other Regulations: Not a listed controlled substance or precursor; compliance with local waste, health, and transportation laws is necessary at all times