Product Name: Ethyl Piperazine-1-Carboxylate
Chemical Formula: C7H14N2O2
Synonyms: 1-Ethoxycarbonylpiperazine
CAS Number: 5894-68-0
Recommended Use: Intermediate in pharmaceutical and agrochemical synthesis
Manufacturer/Supplier: Check supplier label or Safety Officer for details
Emergency Contact: Local poison control center; company emergency hotline as listed on label
GHS Classification: Acute toxicity (oral), Category 4; Skin irritation, Category 2; Eye irritation, Category 2A
Label Elements: Signal word: Warning
Hazard Statements: Harmful if swallowed; Causes skin and eye irritation
Precautionary Statements: Avoid breathing dust/vapors; Wear protective gloves, eye protection; Wash hands thoroughly after handling
Hazard Pictograms: Exclamation mark
Other Hazards: May cause respiratory tract irritation, particularly with chronic exposure; Not expected to be a carcinogen
Chemical Name: Ethyl Piperazine-1-Carboxylate
Concentration: ≥98% by weight
Impurities: Trace solvents (generally less than 1%)
Formula Weight: 158.20 g/mol
EC Number: 227-669-7
Inhalation: Move affected person to fresh air right away. If symptoms such as coughing or shortness of breath develop, seek medical attention
Skin Contact: Take off contaminated clothing. Wash affected area with plenty of soap and water for at least 15 minutes. Get medical help if irritation occurs
Eye Contact: Rinse eyes with plenty of water for at least 15 minutes, keeping eyelids lifted. Get medical help if irritation or visual changes persist
Ingestion: Rinse mouth thoroughly with water. Do not induce vomiting unless directed by medical personnel. Call a doctor or poison control
Most Important Symptoms: Burning or stinging sensation on skin or eyes; stomach upset if swallowed
Notes for Doctor: Treat symptomatically. No specific antidote known
Suitable Extinguishing Media: Use dry chemical, CO₂, foam, or water spray
Unsuitable Extinguishing Media: Do not use high-pressure water streams directly on burning material
Specific Hazards: Combustion produces carbon oxides, nitrogen oxides, irritating fumes
Protective Equipment: Firefighters require self-contained breathing apparatus (SCBA) and full protective gear
Firefighting Procedures: Move containers from fire zone if safe. Cool containers exposed to flame with water spray. Prevent run-off to sewers
Personal Precautions: Wear gloves, goggles, and a lab coat. Avoid dust formation. Ventilate area
Environmental Precautions: Prevent further leakage or spillage. Do not let chemical enter drains or waterways
Spill Cleanup: Collect spillage with absorbent inert material, place in chemical waste container. Wash the site with soap and water
Disposal: Follow local regulations for hazardous waste
Handling: Use only in well-ventilated areas, preferably under a chemical fume hood. Avoid skin, eye, and clothing contact. Wash thoroughly after use. Keep containers tightly closed
Storage: Store in a cool, dry, and well-ventilated place. Keep away from heat and open flames. Store in original container or chemical-resistant containers. Protect from moisture
Incompatible Materials: Strong oxidizing agents, acids, and bases
Threshold Limit Value: No established occupational exposure limits; handle as potentially harmful
Engineering Controls: Use chemical fume hood, local exhaust, emergency eyewash, and safety shower. Maintain adequate ventilation
Personal Protective Equipment (PPE): Safety goggles or face shield, chemical-resistant gloves (nitrile or neoprene), laboratory coat or apron. In dusty or poorly ventilated environments, use an approved respirator
Hygiene Measures: Do not eat, drink, or smoke during use. Remove contaminated clothing and wash before reuse
Appearance: Colorless to pale yellow liquid or crystalline solid
Odor: Mild amine-like
Odor Threshold: Not established
pH: Not determined (solubility in water is low)
Melting Point: Approximately 40–43°C
Boiling Point: 274°C
Flash Point: 112°C (closed cup)
Evaporation Rate: Not established
Flammability: Not classified as highly flammable but can burn at elevated temperatures
Vapor Pressure: Low at 25°C
Vapor Density: Heavier than air
Relative Density: About 1.08 (water=1)
Solubility in Water: Slightly soluble
Partition Coefficient: Log Pow < 1 (predicted)
Auto-ignition Temperature: No data
Chemical Stability: Stable under standard laboratory conditions
Possible Hazardous Reactions: Can react with oxidizing agents to form hazardous products
Conditions to Avoid: Exposure to heat, open flame, moisture
Incompatible Materials: Strong oxidizers, acids, bases
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, nitrogen oxides, toxic fumes
Acute Toxicity: Harmful if swallowed (LD50 oral, rat: ~1200 mg/kg, estimated). Skin and eye irritation observed in animal studies
Skin Sensitization: Not expected, but may cause irritation on contact or prolonged exposure
Inhalation Effects: May cause respiratory irritation and coughing if dust or vapor inhaled in large amounts
Chronic Exposure: Symptoms include dermatitis, allergic reactions in sensitive persons
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA
Mutagenicity: Not expected to be mutagenic by standard assays
Reproductive Toxicity: No data available on reproductive or developmental effects
Ecotoxicity: Not expected to be highly toxic to aquatic life. Aquatic invertebrate LC50 >100 mg/L (estimated)
Mobility: Expected to be low due to limited solubility in water and moderate vapor pressure
Persistence and Degradability: Limited persistence under normal soil conditions; slowly biodegradable
Bioaccumulative Potential: Low; partition coefficient predicts little tendency to bioaccumulate
Other Adverse Effects: Avoid release to the environment based on general caution with amine compounds
Waste Treatment Methods: Dispose in accordance with local, regional, and national regulations. Incinerate under controlled conditions or send to licensed chemical disposal facility
Contaminated Packaging: Empty containers may retain chemical residue. Rinse thoroughly, render unusable, and send to approved waste handler
Special Precautions: Label waste containers appropriately. Do not pour down drains or sewers. Avoid dispersing dust in air
UN Number: Not classified as a hazardous material under current transport regulations
Transport Hazard Class: Not regulated
Packing Group: No assignment
Sea Transport (IMDG): Not regulated for sea shipment
Air Transport (IATA): Not regulated as dangerous goods
Special Precautions: Transport tightly sealed in an upright, leak-proof container. Avoid excessive stacking or exposure to extreme temperatures
TSCA Inventory: Listed
EINECS/ELINCS: Listed under EC No. 227-669-7
REACH Status: Pre-registered, not subject to authorization or restriction at this time
SARA Title III: Not designated as hazardous under Section 302, 304, or 313
California Proposition 65: Not listed
WHMIS Classification (Canada): Not classified as controlled
Other Regulations: Observe occupational exposure limits where applicable, and review site-specific safety practices
