Product Name: Ethyl Imidazole-4-Carboxylate
Chemical Formula: C6H8N2O2
Synonyms: 4-Carboxyethylimidazole, Ethyl 1H-imidazole-4-carboxylate
CAS Number: 872-23-9
Recommended Use: Research, laboratory reagents, intermediate for pharmaceuticals
Supplier Identification: Chemical supplier/distributor information including address and emergency contact number
Emergency Phone: Local/national emergency numbers specific to supplier location
Classification: Irritant to skin and eyes; not classified as highly toxic under GHS criteria
Signal Word: Warning
Hazard Statements: May cause skin and eye irritation, may cause respiratory tract irritation if dust or vapors inhaled
Precautionary Statements: Use proper protective clothing, avoid dust and vapor formation, keep away from heat, wash hands thoroughly after handling
Health Hazards: Irritation to eyes, skin, and mucous membranes; may cause sensitization after repeated exposure
Environmental Hazards: Harmful to aquatic life if released in significant amounts
Pictograms: Exclamation mark symbol for irritant classification
Chemical Name: Ethyl Imidazole-4-Carboxylate
Concentration: 98-100%
Chemical Class: Imidazole compound
Impurities: Trace solvents or unreacted reagents from synthesis process, typically less than 2% by weight
Molecular Weight: 140.14 g/mol
REACH Registration Number: Information provided by supplier if applicable
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and continue rinsing, seek medical attention if irritation persists
Skin Contact: Wash with plenty of soap and water, remove contaminated clothing and shoes, medical attention required if irritation develops
Inhalation: Move person to fresh air, assist breathing if needed, seek medical help if symptoms like coughing or respiratory distress develop
Ingestion: Rinse mouth with water, do not induce vomiting unless directed by doctor, seek immediate medical attention
Symptoms and Effects: Redness, itching or burning sensation, coughing or shortness of breath when inhaled in large amounts
Extinguishing Media: Use dry chemical, CO2, foam, or water spray; avoid using a direct jet of water
Special Hazards: Combustion can produce toxic fumes, including nitrogen oxides, carbon oxides, imidazole decomposition products
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective clothing
Advice for Firefighters: Isolate area, prevent fire water runoff from entering drains or waterways, cool closed containers near fire with water spray
Explosion Sensitivity: No data on explosive limits or sensitivity to static discharge
Personal Precautions: Evacuate unnecessary personnel, avoid breathing dust/vapors, use appropriate PPE including gloves, eye, and respiratory protection
Environmental Precautions: Prevent entry into drains, sewers, waterways, contain the spill using dikes or absorbent material
Cleanup Procedures: Collect spilled material with non-combustible absorbents such as sand or vermiculite, place in suitable closed container for disposal, ventilate area and wash residues with water
Methods and Materials: Use non-sparking tools, wear disposable coveralls, bag contaminated debris for proper chemical disposal
Handling: Handle under well-ventilated conditions, avoid dust generation and inhalation, wear recommended PPE, avoid contact with skin and eyes
Storage: Store in tightly sealed original containers at cool, dry temperature, keep away from heat sources, incompatible materials, and direct sunlight, store away from strong acids, bases, or oxidizers
Preventative Measures: Use secondary containment for liquid stocks, keep tightly closed between uses, wash thoroughly after handling
Incompatibilities: Strong oxidizing agents, strong acids
Exposure Limits: No established occupational exposure limits; minimize dust/vapor exposure
Engineering Controls: Operate in a chemical fume hood, use local exhaust ventilation, use process enclosures where dust may form
Personal Protective Equipment: Chemical safety goggles, impervious gloves such as nitrile, lab coat or protective clothing
Respiratory Protection: NIOSH-approved respirator recommended when handling powder or where ventilation is inadequate
Hygiene Measures: Wash hands before eating or drinking, avoid cross-contamination by handling only in dedicated chemical areas, remove contaminated clothing and wash before reuse
Appearance: White to off-white crystalline powder
Odor: Mild or characteristic imidazole odor
pH: Not available
Melting Point: 138–142°C
Boiling Point: Data not available
Flash Point: Not determined
Solubility: Slightly soluble in water, readily soluble in organic solvents such as ethanol
Vapor Pressure: Negligible at room temperature
Density: 1.22–1.26 g/cm3 (approximate)
Partition Coefficient (log Kow): Data not available
Decomposition Temperature: May decompose at elevated temperatures producing hazardous fumes
Other Data: Substance may cause static buildup, handle with grounding measures if appropriate
Chemical Stability: Stable under recommended storage conditions when kept cool and dry
Reactivity: Not reactive under normal conditions
Possibility of Hazardous Reactions: May react with strong oxidizing agents, can decompose on burning to give toxic fumes
Conditions to Avoid: Excess moisture, heat, sources of ignition
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, imidazole-related breakdown products
Acute Toxicity: Data on LD50 for oral and dermal routes not widely published; considered to be of low acute toxicity based on structural analogs
Irritation: May cause moderate to severe eye and skin irritation
Sensitization: No evidence of skin sensitization in available data
Repeated Dose Toxicity: Sub-chronic and chronic exposure data lacking; not expected to bioaccumulate
Carcinogenicity: Not listed as a known or probable carcinogen by IARC, NTP, OSHA
Mutagenicity: No known mutagenic effects
Developmental Toxicity: No data available on reproductive toxicity
Other Effects: May produce symptoms of irritation, coughing, and discomfort in respiratory tract if inhaled in significant amounts
Exposure Routes: Inhalation, skin contact, eye contact, ingestion
Eco-Toxicity: Harmful to aquatic organisms if large quantities released
Persistence and Degradability: Not expected to persist in the environment, ready biodegradability status unclear
Bioaccumulative Potential: Log Kow not established; based on structure, low tendency to bioaccumulate
Mobility in Soil: Compound likely mobile in soil and water due to moderate solubility
Other Adverse Effects: Avoid large discharges into the environment, no data on toxicity to birds or other wildlife
Waste Disposal Methods: Dispose of material in accordance with local, regional, and national regulations, incineration recommended for organic chemicals when possible
Disposal of Contaminated Packaging: Rinse containers thoroughly, dispose of as hazardous chemical waste
Precautions for Disposal: Do not dump into drains, water bodies, or general landfill
Methods: Collect waste in labeled, tightly sealed containers for handling by accredited chemical waste contractors
UN Number: Not assigned
Proper Shipping Name: Not regulated for transport by air, sea, or road in most jurisdictions
Transport Hazard Class: Not applicable
Packing Group: Not assigned
Environmental Hazards: Not classified as marine pollutant in available literature
Special Precautions: Protect containers from physical damage and moisture, ensure secure packaging and legible labeling for transport
Transport in Bulk: Avoid bulk shipment except under specific conditions that prevent exposure and release
US TSCA Status: Listed or subject to reporting under the Toxic Substances Control Act if imported or produced in the United States
EINECS/ELINCS Status: Listed in European Inventory of Existing Commercial Chemical Substances
OSHA Hazards: Classified as hazardous by irritation criteria
SARA 313: Not listed as a reportable toxic chemical
Canada DSL/NDSL: Present on Domestic Substances List or Non-Domestic Substances List
Other Regulations: Subject to standard environmental, occupational health, and laboratory safety rules in regions where supplied or synthesized
