Material Safety Data Sheet: Ethyl 5-Oxo-L-Prolinate

1. Identification

Product Name: Ethyl 5-Oxo-L-Prolinate
Chemical Name: Ethyl 5-oxo-L-prolinate
CAS Number: 7538-48-1
Synonyms: L-Proline, 5-oxo-, ethyl ester
Recommended Use: Research, chemical synthesis
Supplier: Confidential information available on request
Contact Number for Emergency: Available via supplier

2. Hazard Identification

Hazard Classification: Not classified as hazardous according to GHS
Potential Health Effects: May cause irritation to eyes, skin, and respiratory tract if exposed to large amounts; prolonged exposure may increase the risk of symptoms
Label Elements: Not required for non-hazardous classification, general precautionary pictograms may be suggested
Signal Word: None required
Hazard Statements: No known significant effects
Precautionary Statements: Wash hands thoroughly after handling, avoid inhalation of dust, use in well-ventilated area

3. Composition / Information on Ingredients

Chemical Name: Ethyl 5-oxo-L-prolinate
CAS Number: 7538-48-1
EC Number: 231-791-2
Purity: >98% (typical for laboratory grade)
Impurities: Information available upon request from supplier, typically trace solvent or water content

4. First Aid Measures

Inhalation: Move affected person to fresh air, seek medical attention if breathing is difficult
Skin Contact: Remove contaminated clothing, wash area with soap and water, obtain medical care if irritation persists
Eye Contact: Rinse cautiously with water for 15 minutes, remove contact lenses if present and easy, continue rinsing, seek immediate medical support
Ingestion: Rinse mouth, do not induce vomiting, consult a doctor if unwell or large amounts swallowed
Additional Notes: Treat symptomatically, provide the MSDS to medical professionals if possible

5. Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, or appropriate foam
Unsuitable Media: High pressure water jets may spread spillage
Hazardous Combustion Products: Carbon oxides, nitrogen oxides, may emit irritating or toxic fumes if involved in fire
Protective Equipment for Firefighters: Wear self-contained breathing apparatus, full protective gear
Firefighting Guidance: Avoid inhalation of combustion products, contain and collect fire-extinguishing water

6. Accidental Release Measures

Personal Precautions: Use appropriate personal protective equipment (gloves, goggles, lab coat), avoid inhalation of dust
Environmental Precautions: Prevent spillage from entering drains or the environment, contain spill with inert material
Methods for Clean-up: Scoop up and place in suitable, closed container for disposal, ventilate area, avoid creating dust
Reporting Procedures: Report significant releases as required by local regulations

7. Handling and Storage

Handling: Use only in areas with good ventilation, avoid inhaling powder or vapors, ground and bond containers when transferring large quantities, avoid contact with skin and eyes
Storage Conditions: Store in tightly closed containers in a cool, dry, well-ventilated space, keep away from sources of ignition and incompatible substances
Incompatible Materials: Strong oxidizing agents, strong acids and bases
Storage Class: General chemical storage

8. Exposure Controls and Personal Protection

Occupational Exposure Limits: Not established for this substance
Engineering Controls: Use local exhaust or general ventilation to minimize exposure
Personal Protective Equipment: Chemical-resistant gloves, lab coat, safety goggles, use a dust mask or respirator if ventilation inadequate
Hygiene Measures: Wash hands before breaks and after use, avoid eating, drinking, or smoking in the work area

9. Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: No characteristic odor
Melting Point: 85-90°C (approximate)
Boiling Point: Data not available
Density: Approx. 1.25 g/cm³
Solubility: Slightly soluble in water, soluble in ethanol, methanol, and dimethyl sulfoxide
pH: Not determined
Partition Coefficient (log Pow): Not determined
Flash Point: Not determined, expected above 100°C
Vapor Pressure: Not applicable under normal conditions
Decomposition Temperature: Decomposes with formation of unpleasant fumes

10. Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling conditions
Possibility of Hazardous Reactions: No dangerous reactions known under normal use
Conditions to Avoid: Exposure to moisture, extreme heat, open flames
Incompatible Materials: Strong oxidizing agents, acids, and bases
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides

11. Toxicological Information

Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: No specific data, expected low toxicity based on structure and related compounds
Skin Corrosion/Irritation: May cause mild and transient irritation
Serious Eye Damage/Irritation: May cause redness and discomfort
Respiratory or Skin Sensitization: Data not available, not expected to cause sensitization based on chemical family
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, OSHA
Mutagenicity: No available data
Reproductive Toxicity: No available data
STOT-Single Exposure: Unlikely at laboratory scales
STOT-Repeated Exposure: Prolonged exposure in factory settings might irritate airways
Aspiration Hazard: Not applicable due to physical form

12. Ecological Information

Toxicity to Aquatic Life: Eco-toxicity data not available, expected low toxicity based on chemical category
Persistence and Degradability: Expected to be biodegradable over time; hydrolyzes under environmental conditions
Bioaccumulation Potential: Not expected to bioaccumulate
Mobility in Soil: Likely to have moderate mobility due to solubility properties
Other Adverse Effects: Avoid uncontrolled releases into the environment

13. Disposal Considerations

Disposal Methods: Collect and dispose of in accordance with local, regional, and national regulations; larger quantities require hazardous waste management
Contaminated Packaging: Triple rinse, puncture, and dispose of appropriately, recycle or incinerate through licensed contractors
Precautions: Never discharge into sewers or the environment

14. Transport Information

UN Number: Not regulated for transport
UN Proper Shipping Name: Not applicable
Transport Hazard Class: Not classified as dangerous
Packing Group: Not assigned
Environmental Hazards: Not environmentally hazardous under transport regulations
Special Precautions: Transport with secure packaging to avoid leaks, maintain documentation

15. Regulatory Information

USA TSCA: Listed
EU REACH: Exempt or listed, check supplier for notification
OSHA Hazard Communication: Not classified as hazardous
WHMIS (Canada): Not controlled
Other Regulatory Status: Subject to chemical inventory requirements in major markets
Labeling Requirements: Follow workplace labeling laws; safety instructions and recommended PPE