Product Name: Ethyl 4-Piperidinecarboxylate
Chemical Formula: C8H15NO2
CAS Number: 4546-23-2
Synonyms: 1-Ethoxycarbonyl-4-piperidine
Recommended Use: Chemical intermediate, research and development
Manufacturer Contact: Company name, address, phone, and emergency number should be clearly listed for quick access.
Emergency Phone Number: Local poison control or CHEMTREC contact.
Hazard Classification: Eye irritation category 2, skin irritation category 2, specific target organ toxicity – single exposure
Label Elements: Signal word: Warning; Pictogram: Exclamation mark
Hazard Statements: Causes skin and eye irritation. May be harmful if swallowed or inhaled. Causes respiratory tract irritation.
Precautionary Statements: Wash hands thoroughly after handling. Wear protective gloves, clothing, and eye/face protection. Avoid breathing dust, fumes, or vapors. Use only outdoors or with proper ventilation.
Chemical Identity: Ethyl 4-Piperidinecarboxylate
Common Name: No common trade name in use
Concentration: ≥98% pure
Impurities: Trace organic residuals, solvent (by-product), water (less than 1%)
Additives: None intentionally added
Inhalation: Remove person to fresh air. Seek medical advice if symptoms like dizziness or difficulty breathing appear. Monitor for delayed respiratory symptoms.
Skin Contact: Remove contaminated clothing and rinse skin with plenty of water for at least 15 minutes. Get medical attention if irritation or rash develops.
Eye Contact: Rinse cautiously with water for several minutes, lifting eyelids to ensure thorough flushing. Seek immediate medical help if pain, redness, or vision changes occur.
Ingestion: Do not induce vomiting. Rinse mouth thoroughly with water. Seek immediate medical attention if larger amounts are swallowed or if any symptoms occur.
Note to Physician: Treat supportively. Observe for delayed symptoms from respiratory irritation.
Suitable Extinguishing Media: Use water spray, foam, carbon dioxide, or dry chemical extinguishers.
Specific Hazards: Hazardous decomposition products such as nitrogen oxides and carbon monoxide may be released in a fire. Vapors may form explosive mixtures with air if heated.
Firefighter Protection: Wear full protective gear including self-contained breathing apparatus. Approach from upwind. Suppress (knock down) gases and vapors with water spray.
Special Procedures: Do not use a solid water stream as it may scatter spilled chemical and spread fire.
Personal Precautions: Avoid contact with skin, eyes, and clothing. Ventilate area. Do not breathe vapor or mist. Remove ignition sources.
Environmental Precautions: Prevent further leakage or spillage if safe to do so. Do not allow material to enter drains, surface water, or soil.
Cleanup Methods: Wear proper protective equipment. Soak up with inert absorbent material (sand, earth, vermiculite). Sweep up and shovel into properly labeled containers for disposal.
Notification: Report spills to local authorities as required by regulation.
Handling: Use only with adequate ventilation. Avoid breathing vapors or contact with skin and eyes. Handle in accordance with good laboratory hygiene practices. Ground and bond containers when transferring.
Storage Conditions: Keep in a tightly closed container in a cool, dry, well-ventilated area, away from incompatible substances like strong oxidizers. Protect from heat, sparks, and open flame.
Special Shipping Requirements: Store only in labeled, corrosion-resistant containers. Keep locked up.
Temperature Limitation: Store at 2-8°C for safety; do not freeze or expose to direct sunlight.
Exposure Limits: No occupational exposure standard established specifically for this compound. General chemical exposure limits for organics may apply.
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to maintain airborne levels below recommended exposure limits.
Personal Protective Equipment (PPE): Wear goggles or face shield, chemical-resistant gloves, and laboratory coat or long-sleeved clothing.
Respiratory Protection: Use appropriate respirator if exposure is likely, especially during large releases or in poorly-ventilated rooms. Check fit and filter compatibility.
Hygiene Measures: Wash hands, forearms, and face thoroughly after handling and before eating, smoking, or using lavatory facilities. Remove and wash contaminated clothing before reuse.
Appearance: Clear to faint yellow liquid
Odor: Mild, amine-like
Odor Threshold: Not available
pH: Not applicable (neutral in water solution)
Melting Point: -13°C
Boiling Point: 212°C at 760 mm Hg
Flash Point: 88°C (closed cup)
Flammability: Combustible liquid
Vapor Pressure: 0.67 mm Hg at 25°C
Vapor Density: 4.8 (air=1)
Relative Density: 1.04 g/cm³ at 20°C
Solubility: Slightly soluble in water, soluble in organic solvents (ethanol, ether)
Partition Coefficient (log Kow): 0.5
Auto-Ignition Temperature: Not available
Decomposition Temperature: Not available
Viscosity: Not measured
Chemical Stability: Stable under recommended storage conditions.
Reactivity: Reacts with strong oxidizing agents and acids. May hydrolyze under strong acidic or basic conditions.
Hazardous Reactions: No polymerization anticipated under normal operating conditions.
Decomposition Products: Produces nitrogen oxides, carbon oxides, and other toxic fumes if decomposed by heat or fire. Thermal decomposition may give hazardous vapors.
Likely Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: Oral LD50 (rat) estimated at 900 mg/kg; data limited. Inhalation or skin exposure can cause irritation and mild systemic effects.
Symptoms: Respiratory tract irritation, headache, nausea, skin redness or dryness, eye watering or burning
Chronic Effects: Prolonged or repeated contact may dry or crack skin. No reliable studies linking long-term health effects or cancer in humans.
Sensitization: Not reported as a sensitizer.
Carcinogenicity/Mutagenicity/Teratogenicity: Not listed as a carcinogen or mutagen by IARC, ACGIH, NTP, or OSHA. No evidence of reproductive or developmental toxicity to date.
Additional Data: Incomplete toxicological information for all possible routes of exposure.
Ecotoxicity: Limited data. May cause mild toxicity to aquatic life due to low water solubility.
Persistence and Degradability: Slowly biodegradable. Degradation occurs over weeks.
Bioaccumulative Potential: Low potential, log Kow less than 1.
Mobility in Soil: Likely to move slowly through soil due to low solubility.
Other Adverse Effects: Avoid uncontrolled release into the environment. Regulatory authorities may require reporting for large spills.
Waste Treatment Methods: Consult national and local regulations. Use licensed contractor. Chemical incineration with afterburner and scrubber is preferred.
Waste Disposal: Do not dispose of in general waste or sewers. Store waste in tightly sealed, labeled containers. Dispose as hazardous chemical waste.
Contaminated Packaging: Rinse thoroughly before disposal or recycling. Treat rinsate as hazardous.
Disposal Codes: Consult relevant codes from EPA, local waste authorities, or environmental departments.
UN Number: Not regulated as a dangerous good (non-hazardous for air, ground, or sea transport unless bulk)
UN Proper Shipping Name: Ethyl 4-Piperidinecarboxylate (chemical name)
Transport Hazards Class: Not classified
Packing Group: Not classified
Special Precautions: Handle with care. Secure tightly during transit. Follow shipment documentation procedures. Check transport regulations periodically for changes.
Safety Evaluation: Not specifically listed under major chemical control laws like TSCA (US), REACH (EU) or DSL (Canada) as a regulated chemical.
Label Requirements: Follow local workplace labeling regulations for hazardous chemicals.
International Regulations: Observe Chemical Weapon Convention and all national trade and safety control laws. Export and import notifications may apply.
Inventory Status: May appear on some chemical inventories such as EINECS, TSCA—verification advised prior to use.
Additional Note: Regulatory agencies review chemical listings, so periodic compliance checks support ongoing safety management.
