Product Name: Ethyl 2-Oxopyrrolidine-1-Acetate
Synonyms: 1-Acetoxyethylpyrrolidin-2-one, Ethyl 2-oxo-1-pyrrolidineacetate
Chemical Formula: C8H13NO3
Molecular Weight: 171.20 g/mol
CAS Number: 997-49-5
Use: Intermediate for chemical synthesis, research chemical
Supplier Contact: Refer to product packaging for specific supplier details, including emergency contact hotline and address
GHS Classification: Eye irritation (Category 2A), Skin irritation (Category 2), Specific target organ toxicity—single exposure (Category 3)
Label Elements: Exclamation mark symbol, Hazard and precautionary statements
Hazards: May cause moderate irritation to eyes and skin, risk of drowsiness or dizziness by inhalation, potentially harmful if swallowed
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Signal Word: Warning
Emergency Overview: White to off-white crystalline powder or solid, mild characteristic odor
Chemical Name: Ethyl 2-Oxopyrrolidine-1-Acetate
Concentration: > 97% by weight
CAS Number: 997-49-5
Impurities: <1% (may contain trace levels of process solvents or moisture, not likely to affect classification)
Stabilizers or Additives: None
Inhalation: Move exposed person to fresh air, keep at rest, seek medical attention if symptoms persist, provide artificial respiration if not breathing
Skin Contact: Flush skin with plenty of water for at least 15 minutes, remove contaminated clothing and shoes, seek medical attention for irritation or persistent discomfort
Eye Contact: Rinse immediately with gentle stream of water for at least 15 minutes, hold eyelids apart, remove contact lenses if present and easy to do, seek medical attention if irritation develops
Ingestion: Rinse mouth with water, do not induce vomiting unless advised by medical professional, seek medical attention
Note to Physician: Treat symptomatically based on symptoms and exposure
Suitable Extinguishing Media: Water spray, CO2, dry chemical powder, foam
Special Hazards: May produce irritating or toxic fumes under fire conditions, avoid inhalation of decomposition products
Protective Equipment for Firefighters: Self-contained breathing apparatus (SCBA), protective clothing, gloves, and eye/face protection
Explosion Hazards: Dust may form explosive mixtures with air, use caution with powder handling
Combustion Products: Carbon oxides (CO, CO2), nitrogen oxides may be released
Personal Precautions: Evacuate unnecessary personnel, avoid breathing dust, avoid contact with skin, eyes, and clothing, use personal protective equipment such as gloves, goggles, lab coat or suitable protective clothing, and respiratory protection if dust is generated
Environmental Precautions: Prevent material from entering sewers, drains, surface waterways, or soil, alert environmental authorities if large amounts are released
Containment Methods: Avoid generation of dust, collect powder mechanically and transfer to a clean, dry, labeled container
Cleanup Methods: Use absorbent materials for small spills, sweep up and dispose of in accordance with regulations, ventilate area and wash spill site after material pickup is complete
Decontamination: Wash area of spill with plenty of water and detergent
Handling: Use in a well-ventilated area, minimize dust generation and accumulation, avoid direct contact with substance, wash hands and face thoroughly after handling, do not eat, drink, or smoke during work, keep away from ignition sources and incompatible materials
Storage: Store in tightly sealed original container, keep in a dry, cool, and well-ventilated location, away from incompatible substances such as oxidizers and acids, protect from light and moisture, keep away from food and feed, label storage area and containers clearly
Occupational Exposure Limits: No established ACGIH, NIOSH, or OSHA exposure limits, use workplace exposure control measures as good practice
Engineering Controls: Use chemical fume hood, local exhaust ventilation, or equivalent engineering controls to minimize dust exposure
Personal Protection:
Gloves: Chemical-resistant gloves (e.g., nitrile or neoprene)
Eyes: Safety goggles or chemical splash goggles
Skin: Lab coat or long-sleeved clothing, closed-toe shoes
Respiratory: Dust mask or respirator when exposure to airborne dust is likely
Hygiene Measures: Wash hands before breaks and after handling product, remove contaminated clothing and launder before reuse, do not use near food or beverages
Form: White to off-white crystalline solid
Odor: Mild, characteristic
Odor Threshold: Not determined
pH: Not applicable (insoluble in water)
Melting Point / Freezing Point: 43-46°C
Boiling Point: 272-274°C
Flash Point: 170°C (closed cup, approximate)
Evaporation Rate: Not available
Flammability: Combustible solid
Upper/Lower Flammability Limits: Not determined
Vapor Pressure: Negligible at 20°C
Vapor Density: Not available
Relative Density: Approximately 1.125 g/cm³
Solubility: Low solubility in water, soluble in organic solvents such as ethanol, methanol
Partition Coefficient (n-octanol/water): Not available
Auto-ignition Temperature: Not determined
Decomposition Temperature: Not available
Viscosity: Not applicable (solid)
Chemical Stability: Stable under normal conditions of storage and use
Reactivity: Inert under recommended storage and handling conditions
Possibility of Hazardous Reactions: May react with strong oxidizing agents, acids, or bases
Conditions to Avoid: Avoid moisture, excessive heat, open flames, and materials incompatible with organic esters
Incompatible Materials: Strong oxidizers, strong acids, strong bases
Hazardous Decomposition Products: May yield carbon monoxide, carbon dioxide, and nitrogen oxides during thermal decomposition
Acute Toxicity: Oral LD50 (rat): not well characterized, estimated >500 mg/kg; inhalation and dermal toxicity not well studied
Skin Irritation: May cause mild to moderate skin irritation
Eye Irritation: Risk of moderate irritation
Respiratory Effects: May cause drowsiness or dizziness if inhaled as dust
Chronic Effects: Data lacking on repeated dose toxicity, mutagenicity, carcinogenicity, or reproductive toxicity
Sensitization: Not expected to cause skin or respiratory sensitization based on structure
Target Organ Effects: No data, general caution advised
Additional Information: Handle according to good laboratory and safety practices, avoid unnecessary exposure
Ecotoxicity: Not expected to be highly toxic to aquatic organisms, but avoid release to the environment
Mobility in Soil: Not readily mobile due to low water solubility
Persistence and Degradability: Limited data; esters may hydrolyze slowly in environment, biodegradation may occur on extended timescales
Bioaccumulative Potential: Not expected to present significant bioaccumulation risk
Other Adverse Effects: No data on ozone depletion, endocrine disruption, or other long-term environmental effects, general best practice is to minimize environmental exposure
Waste Methods: Dispose of product and contaminated packaging as hazardous chemical waste, use licensed chemical disposal contractor for proper removal
Disposal Containers: Place waste in sealed, labeled, compatible containers
Special Precautions: Avoid contamination of soil, groundwater, drains, waterways
Local Regulations: Follow local, regional, and national guidelines for disposal of chemical waste materials
Recycling: Chemical recycling not available due to purity and contamination issues, do not attempt to reuse containers after initial contents have been emptied and cleaned by professionals
UN Number: Not regulated as hazardous for transport under UN, DOT, IMDG, IATA
Proper Shipping Name: Not classified as dangerous goods
Transport Hazards Class: Not assigned
Packing Group: Not assigned
Environmental Hazards: Not considered a marine pollutant
Special Precautions for Transport: Keep container tightly closed and secure during transport, protect from physical damage and moisture, avoid elevated temperatures, ensure all documentation accompanies the shipment per local regulations
US Federal Regulations: Not listed on US EPA TSCA Inventory as of latest review, not subject to SARA 313, CERCLA, or RCRA requirements
State Requirements: California Prop 65: not listed; check state-specific chemical listings for details
EU Regulations: Not registered under REACH; not listed as a SVHC (Substance of Very High Concern)
Canada: Not listed on DSL/NDSL; handling and use subject to provincial worker safety rules
Other National Regulations: Consult country- or region-specific chemical safety administration for guidance
Workplace Classification: Use suitable hazard communication labeling within workplace as required by GHS and OSHA Hazard Communication Standard
