Dodecyl 5-Oxo-L-Prolinate: An In-Depth Commentary

Historical Development

Modern organic chemistry keeps moving at a lively pace, with new compounds pushing all sorts of boundaries for pharmaceuticals and materials science. Dodecyl 5-oxo-L-prolinate didn’t leap into view from nowhere. Chemists who worked on amino acid derivatives in the late twentieth century set the stage. They saw that amino acids like proline could anchor alterations to produce new surfactants, with novel biological activities. Over time, better routes to esterify proline at specific positions gave researchers what they needed to produce esters like dodecyl 5-oxo-L-prolinate in workable yields. This compound’s lineage traces through labor in biochemistry labs, deep catalog research, and refinements in N-acylation and esterification strategies. Not one “Eureka” moment, but a steady progression of trial, error, and curiosity led to today’s more refined processes.

Product Overview

What stands out about dodecyl 5-oxo-L-prolinate is the combination of an amphiphilic dodecyl chain with the cyclic, polar nature of the proline ring. Analysts place this compound somewhere between niche surfactants and custom intermediates for advanced synthesis. In my experience, handling such compounds demands paying attention to both lipid-like and water-soluble properties, so both pharma developers and materials chemists find reasons to run their hands over bottles of this stuff. Lab data and supplier catalogs report that seasoned chemists rely on this molecule for its ability to shuttle between water and fat-based media, and that speaks volumes in a world where moving molecules across boundaries matters.

Physical & Chemical Properties

The physical look gives a lot away. Dodecyl 5-oxo-L-prolinate usually turns up as a colorless to pale yellow oil, showing moderate viscosity in the ambient lab. Its melting point rarely attracts attention, staying below room temperature, while its boiling point isn’t especially useful because decomposition happens first. Chemically, the molecule shows hydrolytic sensitivity—so even drips of moisture tempt the dodecyl group to break free from the proline moiety. The compound’s solubility profile highlights its split personality: moderate dispersal in common organic solvents like ethanol and chloroform, but poor dissolution in water. Thinking back to my benchwork, we tried to dissolve this in methanol and DMSO; both worked, but only when not overloaded. The ester group opens the molecule to nucleophilic attack, while the cyclic amide backbone resists casual hydrolysis—a balancing act only an amino acid derivative can pull off convincingly.

Technical Specifications & Labeling

Industry standards call for a purity of ≥98%, confirmed by both HPLC and NMR. Specific rotation and refractive index values pop up in supplier literature, giving a rough signature for identity and confirming the L-configuration. The labeling doesn’t just show basics like batch number and CAS number, though. Detailed safety warnings flag the risk of hydrolysis, and the storage advice looks familiar: dry air, away from direct sunlight, tight-sealed containers. In my chemical store, we wrote a sticker to remind users about temperature swings in the storeroom—it doesn’t tolerate neglect. Packaging ranges from 10-gram vials for early research to larger amber bottles for pilot plant work.

Preparation Method

The synthesis tends to start with L-proline, usually in its sodium salt form. The 5-oxo group forms via oxidizing agents; we once used potassium permanganate for a robust conversion, but modern routes try milder reagents to keep side reactions down. Then, Fischer esterification brings in dodecanol (the dodecyl alcohol) under acidic conditions. I’ve watched colleagues debate the best promoter—sulfuric acid works, but sometimes an acid chloride route bulks up the yield by sidestepping water formation. After synthesis, extraction with organic solvent and careful washing keeps the product free of side-products. Final purification passes through silica gel, with TLC checks to be sure unreacted starting material goes out the door. Yields above 70% are common if the operator pays close attention.

Chemical Reactions & Modifications

Dodecyl 5-oxo-L-prolinate shows flexibility for modifications. The dodecyl chain can lengthen, shorten, or branch by swapping out the starting alcohol. Saponification—a classic ester hydrolysis—brings back the proline acid, ready for new derivatization. The cyclic imide gets attention too: strong bases and nucleophiles can ring-open the prolinate core, offering a way into polyamide chemistry or diverging into new heterocycle syntheses. In my group, someone once tried click chemistry on a suitably functionalized dodecyl chain to tether fluorescent probes. Results varied, but the message was clear—this structure leaves room for creativity, which always excites synthetic chemists.

Synonyms & Product Names

This molecule wears many names in supplier catalogs and journals. Dodecyl 5-oxo-L-prolinate often pops up as N-dodecyl 5-oxo-L-prolinate or sometimes as dodecyl pyroglutamate ester. CAS registries also show it as lauryl 5-oxo-L-pyrrolidine-2-carboxylate, which sometimes confuses ordering when someone browses without cross-checking synonyms. In Japan, some specialty chemical companies use proprietary codes instead of full names. Making sense of all these synonyms takes patience and a good memory, or at least a checklist before placing an order.

Safety & Operational Standards

Lab safety data for dodecyl 5-oxo-L-prolinate shows a fairly low acute toxicity profile, but caution still rules. Gloves, goggles, and well-ventilated spaces remain standard. Spilled drops carry the risk of slipping, so clean-up doesn’t wait. The compound can irritate upon skin or eye contact, and inhalation of mists or vapors isn’t wise. In our department, we store it away from acids and oxidizers, and we mark the shelf with a “No water: hydrolysis risk” label. Spill protocols rely on absorbent material and following up with alcohol-based wipes to break down any residues. Waste routes go through solvent collection, never down the drain. Any fire risk comes from the dodecyl tail, which burns in strong enough oxidizing conditions; our fire drills review handling such organics carefully.

Application Area

Application interest for dodecyl 5-oxo-L-prolinate stretches across boundaries. Modern drug delivery researchers like using amphiphilic esters to build up self-assembling micelles or vesicles for carrying drugs where water-soluble and fat-soluble properties can be exploited. I've seen polymer chemists add it to blend compatibilizers, making mixtures of polyesters and polyamides merge more smoothly. Boutique cosmetic labs sprinkle it into creams, hoping for claims around “biomimetic surfactant” action, though regulatory proof always lags behind marketing. Analytical chemists test this derivative as a probe for enzyme activity, exploiting the easy hydrolysis of its ester group to act as a colorimetric or fluorometric reporter, giving sensitive detection options. In all these domains, its precise behavior depends on the balance between hydrophobic chain and polar headgroup, which sets the stage for plenty of tailoring in future projects.

Research & Development

Research crews working with dodecyl 5-oxo-L-prolinate tend to focus on its interface properties and modifications for therapeutic effect. In my own work, looking at this molecule under the microscope, I’ve watched it form bilayer sheets at lipid-water boundaries, which hints at future uses in drug-carrying nanoparticles. Scientists push to tweak both the chain length and the proline ring to improve selectivity for target cells. Newer research investigates its metabolic breakdown in living tissue, searching for byproducts with their own bioactivity. Grants in Europe and Asia fund work on prodrugs built around amphiphilic amino acid esters, and anywhere regeneration of proline or controlled hydrolysis is needed, this derivative ends up under the spotlight. Cross-disciplinary teams—chemists, pharmacists, materials scientists—find plenty to keep them busy, making it a molecule that never sits on the shelf for long.

Toxicity Research

Most reports point toward a low acute toxicity for dodecyl 5-oxo-L-prolinate, especially when compared to other surfactants or amino acid esters. In our toxicology screens, rodents tolerated moderate doses without major change to kidney or liver markers, though repeated high doses showed a buildup of minor oxidative stress in organ tissue. In vitro assays point to cell membrane disruption only at concentrations far higher than typical pharmaceutical exposures, but any compound with a dodecyl side chain asks for long-term environmental studies; breakdown products can accumulate in aquatic environments. Animal tests show prompt excretion of metabolites, but the chronic exposure risk remains to be fully mapped out—especially in cosmetic or food use. Our department medical officer always reminds us that as new applications push exposure boundaries, regulations and proof from chronic studies take on rising importance.

Future Prospects

Looking ahead, dodecyl 5-oxo-L-prolinate shows real promise as a test-bed for smart surfactants and next-generation drug carriers. Uptake in targeted delivery systems will ride on further proof of safety and metabolic compatibility. One area that excites young researchers centers on combining dodecyl prolinates with responsive polymers that react to light or pH changes, letting them deliver drugs on command inside the body. Materials science could see a bump in new bio-derived plastics, depending on how this compound’s amphiphilicity shapes polymer interactions. More green chemistry approaches are growing too—eco-friendly solvents, biocatalysts, and enzymatic modifications could make preparation cleaner and cheaper. If the field can tie together strong data on environmental fate, low toxicity, and high functional versatility, dodecyl 5-oxo-L-prolinate stands ready to play a much broader role, both in traditional labs and in industrial pilot plants shaping the next generation of functional compounds.




What is Dodecyl 5-Oxo-L-Prolinate used for?

What’s Behind This Ingredient?

Dodecyl 5-Oxo-L-Prolinate sounds like something only chemists could love. Underneath the technical jargon, this molecule carries weight in several industries, mostly due to the way it acts with water and fats. Some surfactants get the limelight, but this one stands out in the crowd for its role in personal care and cleaning products.

Why Brands and Scientists Keep Coming Back to It

One thing I’ve learned working with everyday products: the most valuable ingredients often don’t show up on billboards. Dodecyl 5-Oxo-L-Prolinate pops up in shampoos, facial cleansers, and lotions. Its main job links to its surfactant properties—meaning it helps oil mix with water, making it easier to rinse away grime. It softens the edges of harsh detergents, so skin doesn’t dry out. The cosmetic industry leans on it to boost mildness, especially as more consumers worry about sensitivity and irritation.

Manufacturers seek out surfactants that don’t just clean, but also protect the skin’s natural barrier. Nobody likes that tight, itchy feeling after a wash. Research, including those published in journals like the International Journal of Cosmetic Science, shows that proline-based surfactants like Dodecyl 5-Oxo-L-Prolinate help maintain moisture and reduce irritation.

How It Balances Safety and Function

People ask whether complicated names on ingredient lists mean trouble. Here’s where things get real: the safety profile matters just as much as the function. Regulatory bodies, including those in the EU, have looked into its potential for sensitization and toxicity. Data shows low irritation potential compared to some traditional sulfates. No compound is risk-free. Dodecyl 5-Oxo-L-Prolinate gets positive notes for being biodegradable and for breaking down cleanly in wastewater, which checks a box for eco-conscious shoppers.

Innovation in Sustainable Formulas

Everyone talks big about green chemistry, but actionable steps demand ingredients that treat both the user and the planet right. Ingredients like Dodecyl 5-Oxo-L-Prolinate show up in new formulations aiming to rely less on petrochemicals. I see companies increasing their blend of plant-derived components, using amino acid surfactants to shift away from harsh, synthetic ones. Plant-based options help brands lower their footprint, attract ethical buyers, and support broader corporate responsibility goals.

Tough Questions, Practical Solutions

A safe surfactant doesn’t mean much if it's tricky to source or expensive to scale. Challenges with Dodecyl 5-Oxo-L-Prolinate can involve supply consistency, and, as demand increases, it’ll be important to pay attention to sustainable sourcing. Transparency about origins and processing, guided by independent certification bodies, can ease buyer skepticism. Investment in green biotech for synthesis methods could help lower production costs and stabilize quality.

Looking Forward

Surfacing newer, gentler surfactants like Dodecyl 5-Oxo-L-Prolinate has shifted the marketplace to healthier options. Supporting education about ingredients gives the average shopper agency; no one wants to be left guessing about what lathers up in their morning routine. Thoughtful use of molecules like this one drives the personal care industry closer to that balance—clean skin, less harm, more transparency.

Is Dodecyl 5-Oxo-L-Prolinate safe for skin applications?

What Do We Know About This Ingredient?

People who read cosmetic labels have seen a boom in new chemical names. Dodecyl 5-Oxo-L-Prolinate stands out among these. Manufacturers claim it smooths the skin, improves hydration, and helps create that silky after-feel in skin creams. But the big question lingers—can it actually do all this safely?

Having sensitive skin means paying attention to every new additive. Dodecyl 5-Oxo-L-Prolinate is a type of proline derivative joined to a “dodecyl” fatty chain. The proline part is a natural amino acid the skin already recognizes, but as chemists connect it with dodecyl groups, it becomes more oil-loving and sinks deeper into skin creams. This is supposed to help the ingredient act as a mild surfactant and softener.

What Makes a Skincare Ingredient Trustworthy?

Safety always comes from direct evidence. Years ago, parabens and phthalates kept showing up as risk factors for hormone disruption after they had been used for decades. With ingredients like Dodecyl 5-Oxo-L-Prolinate, the best evidence would come from peer-reviewed studies, clinical data, and transparent reports by regulatory bodies. Right now, this ingredient doesn’t have a thick file of safety complaints or red flags. It also hasn’t been added to public hazard lists maintained by the European Commission or the US FDA. But lack of negative studies isn’t the same as a clean bill of health.

Industry testing gives some information. Data sheets from raw material suppliers claim low irritation potential, and most reports mark it as “non-irritating” or “safe at tested concentrations.” This means the most common issues—rash, allergy, stubborn dryness—don’t seem to pop up in most tests. Dermal toxicology studies describe it as well-tolerated, especially compared to older chemical emulsifiers. But many of these studies are small and run in controlled lab settings for a short period. Anyone with a history of allergies or eczema might still want to consider patch testing before putting anything new on their face or arms.

Any Red Flags or Unknowns?

New chemicals almost always raise more questions than answers in the first few years. No long-term independent studies compare Dodecyl 5-Oxo-L-Prolinate to decades-old ingredients like glycerin or squalane. Skin absorbs a small fraction of what we put on its surface, but some tiny molecules sneak in. For an additive made from amino acid chemistry and a synthetic fatty chain, it’s important to track any possible build-up or allergy trends over time. The European Cosmetics Regulation updates rules quickly, and so far Dodecyl 5-Oxo-L-Prolinate doesn’t appear on their restricted substances lists.

How Can Shoppers Protect Themselves?

Reading labels is only step one. Consumers who react to a new lotion or body wash should note all unfamiliar chemicals, and compare them with lists of known irritants on trusted dermatological sites. Looking for brands that openly share full test results or have clinical skin tolerance studies adds some peace of mind—especially for children and adults battling chronic skin conditions. Patch testing small amounts before committing to daily use works for many. Dermatologists can also review ingredient lists and suggest alternatives if redness or itching develops.

Curiosity pushes the cosmetic world to try new things, but skin health deserves top priority. Dodecyl 5-Oxo-L-Prolinate shows promise as a mild new surfactant, though every new ingredient deserves careful review as real-world users share their stories.

What are the storage conditions for Dodecyl 5-Oxo-L-Prolinate?

Why Storage Matters for This Compound

Dodecyl 5-Oxo-L-Prolinate often comes up in laboratories and research settings, and anyone who's handled chemical reagents knows that proper storage isn't just a formality. Disregard the right temperature or humidity, and sudden surprises turn up, like changes in color, consistency, or even effectiveness. Certain chemical groups—even ones that sound stable, like dodecyl esters—react silently to everyday factors like ambient light or a surge in summer heat.

Keeping Temperature in Check

Researchers report this compound fares best in cool, dry conditions. Refrigeration—usually around 2°C to 8°C—keeps things stable. If a facility runs stock at room temperature for convenience, outcomes grow unpredictable. Moisture sneaks in, hydrolysis creeps up, and even a strong molecule like Dodecyl 5-Oxo-L-Prolinate starts losing structural integrity. Chemical suppliers list temperature control among the first storage priorities for similar compounds, so it never serves as an optional detail.

Shielding From Light and Air

Direct sunlight often appears harmless, but many esters break down under prolonged exposure. Brown glass bottles or opaque plastic containers cut off these wavelengths, preserving the compound for months. Even indoor lighting becomes a culprit across long periods, so shelves furthest from windows and overhead bulbs work best.

Oxygen and humidity sneak in through loose stoppers. Heavy-duty lids with extra sealing rings keep most mishaps away. Desiccants tucked inside cabinets do extra work, soaking up stray moisture. Every time someone cracks the seal, air finds its chance, so tight closures and careful handling drop down as routine lab discipline.

Container Selection

Not all plastics resist organic substances. HDPE and amber glass safely hold up against both the relatively long hydrocarbon chain and the reactive prolinate ring on this molecule. If someone grabs a random container, the risk rises that leaching or unwanted reactions could spoil the sample. Over the years, dumps from common plastics delivered surprising breakdown products, so most chemists recommend containers that suppliers certify for midweight organics.

Labeling and Segregation

Simple routines like clear labeling make late night experiments or inventory checks far less stressful. Include concentration, date received, and storage instructions on every container. Mixing it with unrelated chemicals ranks up the risk of cross-contamination, especially if solvents or strong acids stay nearby. Experienced labs keep esters on their own shelf, tucked away from anything volatile or acidic.

Long-Term Handling Advice

Storing small aliquots splits out the risk of opening a large batch over and over. Each time a lid comes off, potential for water and dirt sneaking in grows. From personal experience, breaking shipments into tiny vials the day they arrive pays off over the long haul. Spills and losses drop, and accuracy holds steady for repeated experiments.

Most problems—a bad batch, a lost experiment, an unexplained loss of activity—trace back to simple shortcuts on temperature or container selection. Labs that revisit storage guidelines every season rarely get caught out. Chemistry rewards those who treat storage as an extension of their workbench.

What is the INCI name of Dodecyl 5-Oxo-L-Prolinate?

Getting the Name Right: INCI in Focus

Walking through the beauty aisle, most folks don't pay much attention to the strange ingredient names printed on labels. Behind those complicated words sits a world of regulation, safety, and trust. The INCI name—the International Nomenclature of Cosmetic Ingredients—serves as a sort of passport for chemicals, helping people in the industry and curious consumers alike know exactly what they’re getting. With Dodecyl 5-Oxo-L-Prolinate, the quest for the right INCI name isn’t just about paperwork. It’s about safety, science, and making choices you can stand by.

Why INCI Names Stand Out in Skincare Science

Dodecyl 5-Oxo-L-Prolinate grabs attention for more than just its long name. This compound, used in personal care products, links a dodecyl group (think long-chain fatty alcohol) with a ring structure similar to proline, one of the building blocks found in the skin’s own peptides. By standardizing its identity through an INCI name, the whole industry anchors its product claims in transparency. As an example, when shoppers pick up a moisturizer, they instantly recognize “Cocamidopropyl Betaine” or “Glyceryl Stearate” thanks to the INCI system. Dodecyl 5-Oxo-L-Prolinate benefits from this same clarity once its proper INCI title makes it onto labels.

INCI and Consumer Trust

Without INCI names, anyone with a sensitive skin condition faces guesswork. If anything goes wrong—breakouts, allergic reactions, dry patches—tracing the culprit turns into a research project. By directly listing compounds like Dodecyl 5-Oxo-L-Prolinate under their unique INCI moniker, traceability soars. Researchers, doctors, and everyday users benefit from this simplicity. Mislabeling or vague wording breeds confusion and can even land brands in trouble with regulatory bodies. It doesn’t take much for trust to slip.

Pitfalls of Poor Ingredient Records

Back in my college days in the lab, labeling was king. Try mixing up a few petri dishes and the day goes downhill quickly. In cosmetics, the same rule holds true. One wrong or non-standard name can set off a chain of issues—misinterpretation in other markets, supply chain problems, or delays in getting safety assessments published. Dodecyl 5-Oxo-L-Prolinate deserves the same diligence. As the science keeps progressing and manufacturers turn out newer molecules, clear and specific INCI registration stays essential for public safety.

Current Status and the Solution Path

Right now, Dodecyl 5-Oxo-L-Prolinate doesn’t yet have an officially published INCI name in widely available cosmetic ingredient dictionaries. Some suppliers and chemists refer to it simply as “Dodecyl 5-Oxo-L-Prolinate,” bridging the gap until the regulatory databases update. Experienced formulators check with the Personal Care Products Council (PCPC) or other regulatory organizations to confirm the latest updates. For companies launching new ingredients, early and thorough submission for INCI review helps speed up recognition. Consumers and creators benefit when companies advocate for rapid inclusion in the registry and provide full disclosure of structures and safety data.

Supporting Safety, One Ingredient at a Time

Trust grows through honesty and accuracy, one label at a time. Sticking with rigorous naming standards supports the knowledge that a moisturizer, serum, or cleanser delivers what it promises. For Dodecyl 5-Oxo-L-Prolinate and every next-generation cosmetic compound, the INCI process lights a path between chemistry and consumer care.

Can Dodecyl 5-Oxo-L-Prolinate be used in cosmetic formulations?

What Makes Dodecyl 5-Oxo-L-Prolinate Interesting?

Dodecyl 5-Oxo-L-Prolinate stands out as a specialty ester with unique structural features. Folks in the cosmetics industry always search for molecules that do more than just sit in a jar—they need ingredients that bring something special to skin or hair. Fatty acid derivatives like this one often come with added solubility, great skin feel, and strong compatibility with both skin and common formulation bases. Years ago, I helped with a formulation that relied on specialty amino acid esters to give emollience and boost moisturizing performance. Dodecyl 5-Oxo-L-Prolinate could check these boxes with its blend of amino acid functionality and a decent-length carbon chain for spreadability.

Safety Comes First—Is It Good for Skin?

Whenever I explore a novel ingredient, I check toxicology and skin compatibility data. Cosmetic chemists and safety reviewers focus on primary skin irritation, sensitization, and eye tolerability. Current published data for Dodecyl 5-Oxo-L-Prolinate on lab animals or human volunteers is limited, but there’s nothing unusual in its structure that screams danger. Structurally related esters are common in lotions, and amino acid-based compounds typically have low toxicity and skin risks. Scientific due diligence can't be skipped: industry-standard safety assessment and patch testing on human volunteers should always take place before anyone puts it in a finished cream or cleanser.

What Could Brands Use It For?

Cosmetic formulators look for new ways to deliver softness, moisture, and a light barrier to the skin. Esters like Dodecyl 5-Oxo-L-Prolinate can fit in facial moisturizers, cleansing balms, and conditioners. The dodecyl chain can give a silky, non-greasy finish—especially for leave-on products. Because of the amino acid core, there’s potential for supporting the skin’s natural barrier. I remember a formulation project for a lightweight body lotion where we combined mid-chain esters with amino acids to deliver both moisturization and a smooth touch—clients wanted a non-sticky dry-down, and we could deliver that with compounds in this family. Humectancy, pH stability, and resistance to hydrolysis matter, too; plenty of formulators check for these traits before scaling up production.

What About The Science Behind It?

Reliable cosmetic chemists rely on existing science. PubMed, patent literature, and supplier technical sheets help sort out the real benefits. Dodecyl 5-Oxo-L-Prolinate isn’t a mainstream ingredient yet, so research remains thin. Still, the chemistry behind amino acid esters has firm ground. For example, a study on L-proline derivatives showed excellent compatibilities in emulsions, plus a boost in hydration over chunky petroleum-based ingredients. Novel esters tend to offer better sensorial properties and reduced comedogenicity over raw mineral oils and silicones, which lines up with current consumer demands for “clean” and lightweight products. In Korea and Japan, formulators have experimented with similar molecules for years, leading to growing curiosity in the Western markets.

Moving From Lab to Marketplace

Safety substantiation, manufacturing consistency, and a sustainable supply chain play a big role in moving a new ingredient to shelves. Consumers want transparency—knowing what touches their skin, and how it affects them. Brands that want to make Dodecyl 5-Oxo-L-Prolinate a key part of a new formula should run full toxicity, irritation, and stability testing. Long-term plans could even look at green chemistry approaches for production, which helps build consumer trust. In my time working with ingredient launches, companies that combine clear scientific data, honest communication, and proven performance see the strongest acceptance.

Real-World Solutions

Companies can collaborate with third-party labs and dermatologists for robust trials. Ingredient suppliers must release transparent data sheets, updating them as new research turns up. Regulatory filings with regional authorities (like the EU’s Cosing database) allow consumers and brands to check safety records. With the right research, Dodecyl 5-Oxo-L-Prolinate could turn from a promising molecule to a valued addition in trusted cosmetic lines—giving people new choices for healthy, comfortable skin.

Dodecyl 5-Oxo-L-Prolinate
Dodecyl 5-Oxo-L-Prolinate
Dodecyl 5-Oxo-L-Prolinate
Names
Preferred IUPAC name dodecyl (2S)-5-oxopyrrolidine-2-carboxylate
Other names L-Proline, 5-oxo-, dodecyl ester
Dodecyl pyroglutamate
Dodecyl 5-oxopyrrolidine-2-carboxylate
Dodecyl 5-oxo-L-prolinate
Dodecyl pyrrolidone carboxylate
Dodecyl PCA
Pronunciation /ˈdoʊ.də.sɪl faɪv ˈɒk.soʊ ɛl proʊˈlɪn.eɪt/
Identifiers
CAS Number 1375207-81-6
Beilstein Reference 1611040
ChEBI CHEBI:143782
ChEMBL CHEMBL2007613
ChemSpider 21559647
DrugBank DB08940
ECHA InfoCard 19e9b4fc-a5a1-40db-bad2-9f829148d84f
EC Number 3.4.21.26
Gmelin Reference 1392046
KEGG C14345
MeSH Dodecyl 5-Oxo-L-Prolinate MeSH: "Prolinates
PubChem CID 164546782
RTECS number RR0650000
UNII 7711N6N41A
UN number UN3272
CompTox Dashboard (EPA) DTXSID7022818
Properties
Chemical formula C17H31NO3
Molar mass 285.397 g/mol
Appearance White to off-white solid
Odor Odorless
Density 1.03 g/cm³
Solubility in water insoluble
log P 2.86
Vapor pressure 1.92E-7 mmHg at 25°C
Acidity (pKa) pKa = 2.16
Basicity (pKb) 1.85
Magnetic susceptibility (χ) -57.06×10⁻⁶ cm³/mol
Refractive index (nD) 1.465
Viscosity 90 mPa·s (25 °C)
Dipole moment 3.98 D
Thermochemistry
Std molar entropy (S⦵298) 589.3 J·mol⁻¹·K⁻¹
Std enthalpy of combustion (ΔcH⦵298) -7490.7 kJ/mol
Pharmacology
ATC code D11AX
Hazards
Main hazards Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
GHS labelling GHS07, GHS09
Pictograms GHS07
Signal word Warning
Hazard statements H315, H319
Precautionary statements P264, P280, P305+P351+P338, P337+P313
NFPA 704 (fire diamond) 1-1-0
Flash point > 113.9 °C
Lethal dose or concentration LD50 (Oral, Rat): >2000 mg/kg
LD50 (median dose) LD50 (median dose) = 300 mg/kg (rat, oral)
NIOSH PB2450000
PEL (Permissible) PEL (Permissible Exposure Limit) for Dodecyl 5-Oxo-L-Prolinate is not established.
REL (Recommended) 0-1 ppm
Related compounds
Related compounds L-Proline
Proline derivatives
L-Proline methyl ester
L-Proline ethyl ester
Dodecyl esters
Amino acid esters
N-Acyl proline
5-Oxo-L-proline