Product Name: Dichloro-1,2-Thiazole-5-Carboxylic Acid
Synonyms: 2,4-Dichloro-1,2-thiazole-5-carboxylic acid
CAS Number: 183875-00-3
Recommended Use: Research, synthesis, chemical intermediate
Supplier: Specialty chemical manufacturers, laboratory supply firms
Contact Information: Emergency contact number of the local poison control center and supplier phone number
GHS Classification: Acute Toxicity (Oral, Dermal, Inhalation); Eye Irritation; Skin Sensitizer; Environmentally Hazardous Substance
Signal Word: Danger
Hazard Statements: Harmful if swallowed, toxic in contact with skin, causes skin irritation, causes serious eye damage, toxic to aquatic life with long lasting effects
Pictograms: Skull and crossbones, exclamation mark, environment
Precautionary Statements: Avoid breathing dust or fumes, wear protective gloves and eye/face protection, avoid release to environment, wash thoroughly after handling
Risk Phrases: May cause burns to skin and eyes, harmful if inhaled or ingested, may cause allergic skin reaction on contact
Chemical Formula: C4Cl2NO2S
Purity: Greater than 98%
Impurities: Traces of dichlorothiazole isomers, unreacted starting materials
Component: Dichloro-1,2-Thiazole-5-Carboxylic Acid, concentration 100%
General Advice: Seek immediate medical attention if symptoms develop
Inhalation: Move exposed individual to fresh air, keep person warm and at rest, administer artificial respiration if breathing has stopped
Skin Contact: Remove contaminated clothing immediately, wash skin with plenty of soap and water for at least 15 minutes
Eye Contact: Rinse opened eye with running water for 15 minutes, lifting upper and lower eyelids occasionally
Ingestion: Rinse mouth with water, do not induce vomiting unless directed by medical personnel, never give anything by mouth to an unconscious person
Most Important Symptoms: Irritation of skin and mucous membranes, severe eye irritation, headache, nausea, allergic reactions
Suitable Extinguishing Media: Use water spray, alcohol resistant foam, dry chemical, or carbon dioxide
Unsuitable Extinguishing Media: Strong water jets can spread chemical
Specific Hazards: Thermal decomposition produces hazardous gases such as nitrogen oxides, sulfur oxides, hydrogen chloride, phosgene
Protective Equipment for Firefighters: Wear self-contained breathing apparatus, full protective gear
Special Procedures: Cool exposed containers with water spray
Advice for Firefighters: Approach from upwind, consider evacuating area
Personal Precautions: Evacuate unnecessary personnel, ventilate area, wear appropriate protective equipment including gloves, eye protection, and suitable respiratory protection
Environmental Precautions: Prevent further leakage or spillage if safe to do so, avoid entry into sewers or waterways, contain and collect spillage
Methods for Clean-up: Scoop up solid material, use approved absorbent material for liquids, place in secure chemical waste container, wash contaminated area with detergent and water
Other Information: Dispose of contaminated materials as hazardous waste
Handling: Use only in well-ventilated areas, avoid contact with skin, eyes, and clothing, avoid inhalation of dust or vapors
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing, do not eat, drink, or smoke while handling this product
Storage Conditions: Store in tightly sealed containers, keep in dry, cool, well-ventilated area, protect from moisture and direct sunlight
Storage Incompatibility: Avoid storing with strong acids, strong bases, oxidizing agents
Packaging Materials: Store in original packaging, ensure containers remain properly labeled
Engineering Controls: Local exhaust ventilation, eye wash stations, safety showers in work area
Exposure Limit Values: No established occupational exposure limits, but treat as hazardous
Personal Protection–Respiratory: Use approved particulate respirator in absence of adequate ventilation
Eyes: Use safety goggles or face shield
Hands: Wear chemical-resistant gloves (nitrile, neoprene)
Skin: Wear lab coat, apron, or protective suit
Environmental Protection: Avoid release to environment; maintain containment and waste protocols
Appearance: Crystalline powder, color may range from off-white to pale yellow
Odor: Characteristic, pungent
Melting/Freezing Point: 145–150°C
Boiling Point: Decomposes before boiling
Flash Point: Not applicable
Flammability: Non-flammable, but may support combustion at elevated temperatures
Explosive Limits: No data available
Vapor Pressure: Low, negligible at room temperature
Solubility: Slightly soluble in water, soluble in organic solvents like methanol and dichloromethane
Density: 1.7–1.8 g/cm³
pH (solution): Acidic in water
Chemical Stability: Stable under ordinary conditions of use and storage
Reactivity: Reacts with strong bases and oxidizers, may form hazardous decomposition products
Thermal Decomposition: Releases toxic gases including HCl, NOx, SOx, phosgene at elevated temperatures
Incompatible Materials: Alkalis, oxidizing agents, strong reducing agents, strong acids
Hazardous Polymerization: Will not occur
Other Hazards: Prolonged exposure may degrade material leading to dangerous byproducts
Acute Toxicity: Harmful by oral, dermal, and inhalation exposure; estimated LD50 (oral, rat) between 200–1000 mg/kg
Skin Corrosion/Irritation: Causes moderate to severe skin irritation
Serious Eye Damage/Eye Irritation: Severe damage to eyes, risk of blindness on direct exposure
Respiratory Sensitization: May cause respiratory tract irritation, coughing, shortness of breath
Skin Sensitization: May cause allergic reactions on repeated or prolonged contact
Chronic Effects: No adequate data for long-term exposure; theoretical concern for liver, kidney, and blood impacts
Carcinogenicity: Not listed by IARC, NTP, or OSHA as a known carcinogen
Mutagenicity: No specific data available, handle with precautions for hazardous chemicals
Reproductive Toxicity: No conclusive data available
Toxicity to Aquatic Organisms: Highly toxic to fish and invertebrates, LC50 values (fish, 96 hours) below 10 mg/L
Persistence and Degradability: Expected to be persistent in the environment, slow biodegradation
Bioaccumulative Potential: Potential for bioaccumulation in aquatic organisms based on structure
Mobility in Soil: Low to moderate mobility, may leach to groundwater if released
Other Adverse Effects: Harmful to aquatic environments even at low concentrations; take precautions to prevent environmental release
Waste Treatment Methods: Collect and contain as hazardous waste, dispose through licensed chemical waste contractor
Contaminated Packaging: Dispose of in accordance with local, regional, and federal regulations
Special Precautions: Do not dispose of in household waste, do not allow material to reach waterways, avoid incineration without scrubber system
Recommended Disposal: Incinerate in approved facility, neutralize acidic residues under controlled conditions
UN Number: UN 2811
Proper Shipping Name: Toxic solid, organic, n.o.s. (Dichloro-1,2-Thiazole-5-Carboxylic Acid)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Labels: Toxic substance diamond and environmentally hazardous substance
Special Transport Precautions: Secure containers, keep upright, ensure compatibility with packaging, prevent leaks
Marine Pollutant: Yes
Additional Information: Follow all national and international transport regulations, including IMDG, IATA
TSCA Status: Not specifically listed; production for research purposes may be exempt
REACH Registration: Pre-registered for research; not authorized for broad commercial applications in EU without further evaluation
SARA Title III Sections 302/304: Not listed
SARA Title III Section 313: Not listed as reportable chemical
California Prop 65: Not known to be listed
Workplace Classification: Handle as hazardous chemical under OSHA and local workplace safety rules
Other Regulations: Observe all applicable federal, state, and local regulations regarding handling and release; ensure proper worker training and documentation
