Product Name: D-(+)-Proline
Chemical Name: (R)-Pyrrolidine-2-carboxylic acid
CAS Number: 344-25-2
Molecular Formula: C5H9NO2
Molecular Weight: 115.13 g/mol
Synonyms: (+)-Proline, D-Proline
Supplier Details: Refer to your laboratory’s supplier records for contact and emergency information
Recommended Use: Chemical synthesis, research and development, biochemical reagent
GHS Classification: Not classified as hazardous under GHS
Hazard Statements: No significant hazard identified under normal usage
Signal Word: Not required
Pictograms: Not required
Precautionary Statements: Avoid dust formation; handle under local exhaust ventilation and use with qualified PPE
Health Hazards: May cause mild irritation to eyes, skin, and respiratory tract under high exposure conditions
Environmental Hazards: Expected to be low, limited data available
Chemical Name: D-(+)-Proline
Concentration: ≥ 98% (pure substance)
Impurities and Stabilizing Additives: None listed as hazardous
EC Number: 206-498-7
Other Identifiers: Not listed
Inhalation: Move exposed person to fresh air, support breathing, seek medical advice for symptoms
Skin Contact: Remove contaminated clothing, wash skin with soap and water, seek medical attention if rash or irritation develops
Eye Contact: Rinse eyes carefully with water for several minutes, remove contact lenses if present and easy to do, obtain medical advice for persistent discomfort
Ingestion: Rinse mouth thoroughly with water, never give anything by mouth to an unconscious person, get medical attention in case of adverse symptoms
Most Important Symptoms: Mild irritation possible to eyes, skin, and airways under excessive exposure
Suitable Extinguishing Media: Water spray, carbon dioxide, alcohol-resistant foam, dry chemical powder
Unsuitable Extinguishing Media: Direct water jet may spread the fire
Specific Hazards: Emits toxic fumes of nitrogen oxides and carbon oxides above decomposition temperatures
Special Protective Equipment for Firefighters: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes
Advice for Firefighters: Avoid inhalation of gases or vapors, evacuate the hazard area, use standard fire-fighting measures
Personal Precautions: Avoid creating dust, ventilate the area, wear gloves and safety goggles
Environmental Precautions: Prevent further leakage or spillage, keep out of waterways and sewers
Methods for Clean Up: Sweep up carefully, place in proper container for disposal, clean contact area with water and detergent
Reference to Other Sections: For disposal and PPE, see relevant sections of this sheet
Handling: Minimize dust, avoid inhalation and direct contact, wash hands after use, work in a ventilated area
Storage Requirements: Store in tightly closed container, keep in a cool, dry, well-ventilated location, avoid excessive heat and sunlight
Incompatible Materials: Strong oxidizers, acids, and bases
Safe Transfer Procedures: Use caution with transfers, avoid spills
Control Parameters: No workplace exposure limits assigned
Engineering Controls: Use local exhaust or general room ventilation to reduce exposure
Respiratory Protection: Use dust mask if airborne particles are present or in case of insufficient ventilation
Eye Protection: Safety goggles or face shield recommended for bulk handling
Hand Protection: Wear chemical-resistant gloves
Skin Protection: Wear lab coat or protective clothing
Hygiene Measures: Do not eat or drink while handling, wash thoroughly after work
Appearance: White crystalline powder
Odor: Slight, characteristic
Melting Point: 220–225 °C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Very soluble in water, partially soluble in ethanol
pH: ~6.5 (solution at 10 g/L, 20°C)
Flash Point: Not determined
Explosion Properties: Not explosive
Vapor Pressure: Not applicable
Relative Density: ~1.35 g/cm3
Partition Coefficient: log Kow: -2.41
Auto-ignition Temperature: Not available
Chemical Stability: Stable under recommended handling and storage
Reactivity: No hazardous reactivity observed under normal procedures
Hazardous Reactions: Contact with strong oxidizers may generate exothermic reactions
Conditions to Avoid: Extreme moisture, heat, and incompatible substances
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides
Acute Toxicity: Oral LD50 (rat): >5000 mg/kg, low toxicity
Chronic Effects: No evidence of carcinogenic, mutagenic, or reproductive risks
Irritation: May cause mild skin or eye irritation
Sensitization: Not considered to be a sensitizer based on available data
Other Effects: Excessive exposure may result in gastrointestinal discomfort
Ecotoxicity: Not classified as dangerous to the aquatic environment based on structural properties and data
Persistence and Degradability: Readily biodegradable in environmental conditions
Bioaccumulative Potential: Low, log Kow suggests poor potential for bioaccumulation
Mobility in Soil: Material is water soluble and will move readily in soil
Other Adverse Effects: No known significant effects or critical hazards based on present knowledge
Waste Treatment Methods: Collect and contain material in a designated, labeled waste container
Disposal in Accordance with Regulations: Dispose at approved waste facility or in accordance with local, regional, and national regulations
Contaminated Packaging: Clean containers before disposal or offer to a licensed drum reconditioner
Special Precautions: Avoid release to environment from spills and misuse
UN Number: Not regulated as hazardous for transport under ADR/RID, IMDG, IATA, or DOT
Proper Shipping Name: Not required
Transport Hazard Class: Non-hazardous
Packing Group: Not assigned
Marine Pollutant: No
Special Precautions for Users: Ensure containers are secure prior to transport, protect from mechanical damage
Inventory Listings: Listed in TSCA, EINECS/ELINCS, DSL, and other chemical inventories
SARA Title III (Sections 302, 304, 313): Not listed
California Proposition 65: Not listed as a chemical known to cause cancer or reproductive toxicity
OSHA Status: Not considered hazardous under OSHA rules
Other Regulatory Information: Review all local, regional, national, and international regulations before use
