Product Name: Clindamycin Hydrochloride
Chemical formula: C18H34ClN2O5S·HCl
CAS Number: 58207-19-5
Intended Use: Pharmaceutical synthesis and research
Manufacturer: Contact information must be checked for each supplier, including street address and emergency contact number
Synonyms: Clindamycin HCl, Clindamycin hydrochloride monohydrate
Classification: Harmful if swallowed, may cause allergic skin reaction, suspected of damaging fertility or the unborn child (GHS/OSHA)
Symbol: Health hazard pictogram, exclamation mark
Signal Word: Warning
Hazard statements: Causes skin and eye irritation, may cause respiratory irritation, may cause damage to organs through prolonged or repeated exposure
Precautionary Statements: Avoid breathing dust, use personal protective equipment, wash hands thoroughly after handling, avoid release to the environment
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Chemical Name: Clindamycin Hydrochloride
Concentration: 98-100%
Impurities/Additives: No significant hazardous impurities known for the pharmaceutical-grade compound
Molecular Weight: 461.45 g/mol
Ingredient Type: Active pharmaceutical ingredient
Inhalation: Move exposed person to fresh air. Monitor breathing. Seek medical attention for symptoms like difficulty in breathing or persistent cough.
Skin contact: Remove contaminated clothing and immediately rinse skin with plenty of water and soap for at least 15 minutes. Consult a physician for rash or irritation.
Eye contact: Rinse with copious amounts of water for at least 15 minutes, occasionally lifting upper and lower eyelids. Remove contact lenses if present and easy to do. Seek immediate medical attention if irritation or redness persists.
Ingestion: If swallowed, rinse mouth with water, do not induce vomiting unless directed by medical personnel. Seek immediate medical help, and show this data sheet if possible.
Protection for Responders: Use gloves, goggles, and lab coat to avoid exposure from splashes or dust.
Suitable extinguishing media: Water spray, carbon dioxide, dry chemical powder, foam
Extinguishing media not to use: Strong streams of water—may disperse dust into the air
Specific hazards: Produces hazardous gases—nitrogen oxides, sulfur oxides, hydrogen chloride—on combustion
Protective equipment for firefighters: Self-contained breathing apparatus and full protective clothing
Special procedures: Avoid run-off water contaminating the environment; move containers from fire area if safe
Personal Precautions: Avoid dust formation and direct contact with skin and eyes; wear gloves, mask, and eye protection
Environmental Precautions: Prevent further leakage or spillage if safe to do so; do not let product enter drains
Methods for Clean-up: Sweep or vacuum spilled material using equipment fitted with HEPA filter. Avoid raising dust. Place in a suitable, labelled closed container for disposal. Ventilate area and wash spill site after material pick-up is complete.
Decontamination: Clean with soap and water or detergent, ensure all surfaces free from residues
Precautions for safe handling: Avoid inhalation, ingestion, and contact with skin, eyes, and clothing. Handle in a chemical fume hood, use proper PPE (goggles, gloves, lab coat). Practice good industrial hygiene.
Storage conditions: Store in tightly closed original container in a cool, dry, well-ventilated area away from incompatible materials. Keep away from sources of ignition and moisture.
Storage temperature: 2°C – 8°C (refrigerated), protect from light
Incompatible materials: Strong oxidizers, acids, and bases
Specific practices: Keep container tightly sealed and regularly check for signs of leaks or deterioration.
Engineering controls: Local exhaust ventilation or fume hood; eyewash station and safety shower in work area
Respiratory protection: Use approved respirator if airborne exposure is significant
Skin Protection: Wear gloves (nitrile or latex), long sleeves or lab coat
Eye Protection: Use chemical safety goggles or face shield
General hygiene: Wash thoroughly after handling, remove contaminated clothing, do not eat or drink in work area
Threshold values: No ACGIH, OSHA, or NIOSH exposure limits established for Clindamycin Hydrochloride
Appearance: White to off-white crystalline powder
Odor: Slight or odorless
Solubility: Freely soluble in water, sparingly soluble in alcohol
Melting Point: 141–144°C
pH (solution): 3–5 (aqueous solution)
Boiling Point: Not applicable (decomposes)
Vapor Pressure: Not applicable
Density: 1.3–1.5 g/cm³
Partition coefficient (log Pow): Not determined
Flash Point: Not flammable
Explosive properties: Not explosive
Oxidizing properties: Non-oxidizing
Chemical stability: Stable under recommended storage conditions
Reactivity: No dangerous reactions known under normal use and conditions
Conditions to avoid: Excess heat, exposure to strong oxidizing agents or acids, humidity
Hazardous decomposition products: Carbon monoxide, carbon dioxide, hydrogen chloride, sulfur oxides, nitrogen oxides
Incompatible materials: Strong oxidizers, strong acids and bases
Polymerization: Will not occur
Acute toxicity: Oral LD50 (rat) is estimated to be >5,000 mg/kg; can cause gastrointestinal upset if ingested
Symptoms: May cause allergic reactions, rash, nausea, diarrhea, abdominal pain, or more severe hypersensitivity
Chronic exposure: Long-term ingestion may impact gastrointestinal flora, affect liver function, lead to antibiotic resistance
Sensitization: May cause sensitization by skin contact
Carcinogenicity: Not identified as carcinogen by IARC, NTP, OSHA
Mutagenicity: No evidence from available animal studies
Reproductive toxicity: May harm unborn child based on animal studies
Other effects: Risk of severe colitis including pseudomembranous colitis from killing normal gut flora
Aquatic toxicity: Harmful to aquatic organisms based on antibiotic class, chronic exposure alters microbial populations
Mobility: Moderately mobile in soils, can leach to groundwater under certain conditions
Persistence/degradability: Partial degradation in sewage plants; not readily biodegradable
Bioaccumulation potential: Low, does not tend to accumulate in higher organisms
Other adverse effects: Disturbs local eco-balance by affecting soil and water bacteria; waste should not reach natural waterways or soil
Waste from residues: Dispose of as hazardous pharmaceutical waste according to local, regional, and national guidelines
Contaminated packaging: Dispose of used containers as hazardous waste, after triple rinsing with an approved solvent
Incineration: Recommended method at site licensed to handle pharmaceuticals; avoid discharge into sewers or environment
Special precautions: Minimize transfer of leftover product into municipal waste streams
UN Number: Not classified as dangerous for transport
Proper Shipping Name: Not regulated by ADR, IMDG, IATA
Transport Hazard class: Not applicable
Packing group: Not regulated
Special precautions: Handle sealed containers to avoid dust clouds; keep away from food and feedstuffs during shipment
Labelling according to Regulation (EC) No 1272/2008: Requires hazard pictograms, hazard and precautionary statements according to the substance class
US Federal regulations: Not listed as hazardous under SARA Title III Sections 302, 304 or 313
Drug Enforcement Administration (DEA): Not a controlled substance
Other national regulations: Subject to drug regulations in countries where it is marketed; workplace limits may exist in certain jurisdictions
TSCA: Exempt for pharmaceutical use
WHMIS (Canada): Not regulated
Other applicable rules: Comply with all local, state, national, and international legislation in storage, handling, and waste management
