Chemical Name: Climbazole
Chemical Formula: C15H17ClN2O2
CAS Number: 38083-17-9
EINECS Number: 253-775-4
Synonyms: 1-(4-Chlorophenoxy)-1-imidazolyl-3,3-dimethylbutan-2-one
Recommended Use: Used as an antifungal agent in personal care products
Supplier: See product packaging or supplier documentation for details
Emergency Contact: Refer to local regulation and supplier emergency contacts
Hazard Classification: Classified as hazardous – Eye irritant, Skin sensitizer
GHS Label: Warning
Hazard Statements: May cause eye irritation, May cause skin sensitization in sensitive people
Potential Health Effects: Contact may lead to mild irritation on skin, eyes, or respiratory tract
Routes of Exposure: Inhalation, Skin, Eye contact, Ingestion
Pictogram: Exclamation mark (GHS07)
Substance: Climbazole
Concentration: 97-100% (pure substance)
Impurities: Typically considered negligible under normal handling
Additives: None reported
Hazardous Components: No additional hazardous components in pure product
Inhalation: Remove to fresh air. Seek medical attention if breathing becomes difficult.
Skin Contact: Wash skin thoroughly with soap and water for at least 15 minutes. Remove contaminated clothing.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.
Ingestion: Rinse mouth. Do not induce vomiting. Get medical advice if symptoms develop.
Note to Physicians: Treat symptomatically. No specific antidote available.
Suitable Extinguishing Media: Water spray, dry chemical powder, foam, carbon dioxide.
Specific Hazards: Combustion produces hazardous gases including carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen chloride.
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective clothing.
Fire/Explosion Hazard: Material is combustible under fire conditions.
Special Precautions: Avoid inhalation of combustion by-products.
Personal Precautions: Keep unprotected persons away. Wear suitable gloves, mask, protective goggles.
Environmental Precautions: Prevent entry to sewers, soil, and waterways.
Methods for Cleaning Up: Collect spillage by mechanical means. Place in container for disposal. Wash area with detergent and water.
Reference to Other Sections: See Exposure Controls and Personal Protection for detailed recommendations.
Precautions for Handling: Avoid dust formation. Prevent contact with eyes, skin, clothing. Wash thoroughly after handling.
Storage Requirements: Store in a well-ventilated, cool, dry place. Keep containers tightly closed. Protect from direct sunlight and moisture.
Incompatible Materials: Strong oxidizing agents, acids, bases.
Specific End Uses: Used in anti-dandruff shampoos, personal care products as directed by regulations.
Occupational Exposure Limits: No occupational exposure limit values established.
Engineering Controls: Use in well-ventilated areas. Apply local exhaust ventilation where dust can be generated.
Personal Protection: Use NIOSH-approved respirators if exposure limits are exceeded.
Eye Protection: Chemical safety goggles or face shield.
Skin Protection: Gloves (nitrile or rubber), laboratory coat or suitable protective clothing.
General Hygiene: Wash hands and face after handling. Do not eat, drink, or smoke during use.
Environmental Exposure Controls: Do not release product to the environment.
Physical State: Solid
Appearance: White crystalline powder
Odor: Odorless
Melting Point: 96–99 °C
Boiling Point: Decomposes before boiling
Solubility: Insoluble in water, soluble in ethanol and organic solvents
pH: Not applicable (insoluble in water)
Vapor Pressure: Negligible
Relative Density: 1.19–1.23 g/cm³
Partition Coefficient (log Kow): 2.81 (estimate)
Flash Point: Data not available
Auto-ignition Temperature: No data
Explosive Properties: Not explosive
Oxidizing Properties: Not oxidizing
Chemical Stability: Stable under recommended storage conditions.
Reactivity: Not reactive under normal usage.
Possibility of Hazardous Reactions: Hazardous polymerization will not occur.
Conditions to Avoid: Excessive heat, open flame, moisture.
Incompatible Materials: Strong oxidizers, acids, alkalis.
Hazardous Decomposition Products: Emits toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen chloride on combustion.
Acute Toxicity: Oral LD50 (rat): 3,300 mg/kg
Skin Irritation: Mild irritant
Eye Irritation: Mild irritant
Skin Sensitization: Sensitizing potential based on animal studies and rare human reactions
Chronic Toxicity: No evidence of carcinogenicity or mutagenicity in available studies
Potential Effects: Prolonged or repeated contact may cause allergic reaction in predisposed individuals
Other Information: Inhalation of dust may cause respiratory tract irritation.
Aquatic Toxicity: Toxic to aquatic life. LC50 (fish, 96hr): 0.13 mg/l
Persistence and Degradability: Poor biodegradability in water and soil
Bioaccumulation: Potential for bioaccumulation exists
Mobility in Soil: Low mobility due to low water solubility
Other Adverse Effects: Avoid discharge to the environment without proper treatment.
Waste Disposal Methods: Dispose of in accordance with local, regional, national, and international regulations.
Product Disposal: Do not dispose of in drains, watercourses, or landfill without treatment.
Contaminated Packaging: Dispose of as hazardous waste.
Incineration: Suitable for controlled combustion facilities.
Recycling: Not applicable.
UN Number: Not regulated for transport
UN Proper Shipping Name: Not classified as dangerous goods
Transport Hazard Class: None
Packing Group: None
Special Precautions for User: Avoid generation and inhalation of dust during transport. Prevent spillage.
International Inventories: Listed in TSCA (USA), EINECS/ELINCS (Europe), DSL/NDSL (Canada), ENCS (Japan)
Safety, Health and Environmental Regulations: Subject to cosmetic and chemical regulation in EU, USA, and Asia-Pacific
Restrictions: Use levels regulated in finished cosmetic products depending on region. Refer to local legislation.
Other Regulations: No classified carcinogenic, mutagenic, or reproductive toxicity risks according to available data.
Labelling: GHS label elements required for raw material containers.
