Product Name: Clemizole Hydrochloride
Chemical Formula: C16H20ClN3
Synonyms: 1-(Antihistaminylmethyl)imidazole hydrochloride
CAS Number: 3546-41-6
Recommended Use: Laboratory chemical, medical research, pharmaceutical ingredient
Supplier: Manufacturer contact information listed on packaging
Emergency Contact: Local poison control center or emergency medical provider contact as listed by supplier
GHS Classification: Acute toxicity (Oral, Category 4), Skin irritation (Category 2), Eye irritation (Category 2A), Specific target organ toxicity (Category 3)
Label Elements: Exclamation mark symbol
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin and eye irritation, may cause respiratory irritation
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, wear protective gloves and eye protection, do not eat or drink while handling this material
Hazards Not Otherwise Classified: No data available for other hazards; treat as hazardous if unsure
Clemizole Hydrochloride: 98-100%
Chemical Identity: Clemizole hydrochloride
Impurities: Trace impurities below 0.1% (proprietary, non-disclosed)
Molecular Weight: 289.81 g/mol
Other Components: No additional stabilizers or additives used
Note: Formulated strictly as pure substance for laboratory or medical research use only
Inhalation: Remove individual to fresh air, seek immediate medical attention for persistent discomfort, monitor for signs of respiratory distress
Skin Contact: Wash skin thoroughly with soap and water for at least 20 minutes, remove contaminated clothing, seek medical advice if irritation persists
Eye Contact: Rinse eyes cautiously with water for at least 20 minutes, hold eyelids open, remove contact lenses if present and easy to do, seek immediate medical attention
Ingestion: Rinse mouth with water, do not induce vomiting, seek immediate medical assistance, never give anything by mouth to an unconscious person
Symptoms/Effects: Irritation to upper respiratory tract, redness or swelling on skin, pain, or redness in eyes, nausea and abdominal discomfort or headache may occur
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide
Specific Hazards Arising from Chemical: On thermal decomposition generates toxic fumes: hydrogen chloride, nitrogen oxides, carbon oxides
Protective Equipment for Firefighters: Wear self-contained breathing apparatus, full protective gear, avoid inhalation of combustion products
Firefighting Instructions: Use water to keep fire-exposed containers cool, contain extinguishing water to prevent environmental contamination, evacuate personnel to safe areas
Explosion Data: No reported unusual fire or explosion hazards, dust may form explosive mixture with air under certain conditions
Personal Precautions: Avoid dust formation, ventilate area, evacuate unnecessary personnel, wear protective clothing and respirator
Environmental Precautions: Prevent further leakage or spillage if safe to do so, avoid entry into drains, watercourses, or soil, notify authorities in case of large spills
Containment: Sweep up and shovel using non-sparking tools, avoid dust, collect material in suitable, labeled waste container
Cleaning Up: Decontaminate spill surface using appropriate cleaning agent, ventilate area, wash spill site after material pickup is complete, dispose of according to section 13
Handling: Keep container tightly closed, avoid contact with skin, eyes, and clothing, use appropriate exhaust ventilation, handle in a chemical fume hood, avoid ingestion and inhalation, minimize dust generation
Storage: Store in a cool, dry, well-ventilated area, provide secure, labeled containers, keep away from incompatible substances such as oxidizers or acids, avoid excessive heat or direct sunlight, maintain original packaging if possible, store away from food and drink
Engineering Controls: Use ventilation systems, fume hoods, or local exhaust to keep airborne concentrations below exposure limits
Personal Protective Equipment: Wear approved safety goggles, chemical-resistant gloves (nitrile, neoprene), lab coat or chemical-resistant apron, in areas with dust or insufficient ventilation use NIOSH/MSHA-approved respirator
Exposure Limits: No OSHA/ACGIH exposure limits specified for clemizole hydrochloride, use good industrial hygiene practices
Hygiene Measures: Wash hands before breaks and at end of work, do not smoke, eat, or drink in handling area, remove and wash contaminated clothing before reuse
Appearance: White to off-white crystalline powder
Odor: Odorless or faint chemical scent
Melting Point: 226-230°C
Boiling Point: Not applicable (decomposes)
Solubility: Freely soluble in water, slightly soluble in organic solvents
pH: Not available
Flash Point: Not established
Density: Approximately 1.2 g/cm3
Vapor Pressure: Not relevant at ambient temperature
Partition Coefficient (n-octanol/water): Not determined
Viscosity: Not applicable
Other Properties: Stable at ambient conditions, avoid sources of ignition and incompatible materials
Chemical Stability: Stable under recommended storage and handling conditions
Hazardous Reactions: Reacts with strong oxidizing agents, acids, alkali metals
Decomposition Products: Yields toxic gases including hydrogen chloride, carbon oxides, nitrogen oxides on burning or decomposition
Conditions to Avoid: Excessive heat, open flames, direct sunlight, moisture, incompatible materials
Polymerization: Does not undergo hazardous polymerization under normal conditions
Acute Toxicity: Harmful if swallowed, estimated oral LD50 (rat) approx. 150-500 mg/kg
Skin Corrosion/Irritation: Causes mild to moderate irritation
Serious Eye Damage/Irritation: May cause moderate irritation, redness
Respiratory Sensitization: May cause irritation of respiratory tract
Skin Sensitization: Not classified as a skin sensitizer
Carcinogenicity: Not listed by NTP, IARC, or OSHA as carcinogen
Mutagenicity: No information found
Reproductive Toxicity: No definitive data for reproductive or developmental effects
Specific Target Organ Toxicity – Single Exposure: May cause respiratory tract irritation, headache, dizziness
Chronic Effects: Prolonged exposure not well documented, avoid repeated contact
Ecotoxicity: No quantitative data available; treat as potentially harmful to aquatic life
Persistence and Degradability: No data on environmental degradation; do not release into environment
Bioaccumulation Potential: No data available, unknown risk
Mobility in Soil: No data available
Additional Remarks: Avoid uncontrolled release into environment; report accidental release to authorities as required by law
Waste Disposal Method: Dispose in accordance with local, regional, and national regulations governing waste chemicals
Contaminated Packaging: Triple rinse and handle as hazardous waste, properly label for chemical content
Special Precautions: Do not dispose via landfill or sewage, contact licensed waste disposal contractor
Recommended Disposal: High-temperature incineration or chemical treatment processes under controlled conditions
UN Number: Not classified for transport as a dangerous good under UN, ADR, IATA, IMDG
Proper Shipping Name: Non-regulated
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Marine Pollutant: Not classified as marine pollutant
Special Precautions: Protect from physical damage during transit, transport in accordance with standard laboratory chemical procedures
TSCA Status: Not listed on TSCA Inventory
EU Regulations: Not classified under Regulation (EC) No 1272/2008 (CLP/GHS)
SARA Title III: Not subject to reporting for Sections 302, 304, 311, 312, or 313
California Proposition 65: Not listed
Other National & International Regulations: Comply with local, federal, and international chemical safety regulations as specified by governing authorities
