Product Name: Cis-2,6-Dimethylmorpholine
Chemical Formula: C6H13NO
Synonyms: 2,6-Dimethyl-1,4-oxazinane; Morpholine, 2,6-dimethyl-, cis-isomer
CAS Number: 6365-50-6
Recommended Use: Chemical intermediate, solvents, additives, specialty organic synthesis
Supplier: Chemical manufacturer or distributor as listed on packaging label
Emergency Contact: Refer to local/national poison center or CHEMTREC, emergency response hotline
Restriction on Use: Industrial, laboratory use only; not approved for food, drug, cosmetic, or household use
GHS Classification: Flammable liquid (Category 3), Acute toxicity – oral (Category 4), Skin corrosion/irritation (Category 2), Eye damage/irritation (Category 2A), Specific target organ toxicity – single exposure (Category 3)
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor. Harmful if swallowed. Causes skin and eye irritation. May cause respiratory irritation.
Precautionary Statements: Keep away from heat/sparks/open flames/hot surfaces. Avoid breathing vapors. Wear protective gloves, eye/face protection. Wash hands thoroughly after handling.
Label Elements: Flame, Exclamation Mark pictograms
Potential Health Effects: Irritation to skin, eyes, and respiratory tract. Possible central nervous system effects upon inhalation.
Routes of Entry: Inhalation, ingestion, skin and eye contact
Target Organs: Mucous membranes, respiratory tract, skin, eyes, central nervous system
Chemical Name: Cis-2,6-Dimethylmorpholine
CAS Number: 6365-50-6
Concentration: >98%
Impurities: Trace morpholine derivatives (<2% total impurities)
Additives: No intentional additives
General Advice: Get medical attention if symptoms occur.
Inhalation: Remove person to fresh air. Keep at rest. Seek medical assistance for prolonged symptoms.
Skin Contact: Immediately wash with soap and plenty of water for at least 15 minutes. Remove contaminated clothing.
Eye Contact: Rinse immediately with large amounts of water for at least 15 minutes. Consult an ophthalmologist if irritation develops.
Ingestion: Do not induce vomiting. Rinse mouth with water, never give anything by mouth to an unconscious person. Seek immediate medical attention.
Most important symptoms: Burning sensation, pain, redness, watering of eyes, headache, drowsiness, confusion, gastrointestinal upset
Suitable Extinguishing Media: Carbon dioxide, dry chemical, alcohol-resistant foam
Unsuitable Media: Direct water streams may spread contamination
Protective Equipment: Full protective gear and self-contained breathing apparatus
Specific Hazards: Vapors may form explosive mixtures with air. Emits toxic fumes under fire conditions (nitrogen oxides, carbon monoxide, carbon dioxide)
Special Procedures: Keep containers cool with water spray if exposed to fire. Prevent run-off into drains, sewers, or water sources.
Hazardous Combustion Products: Nitrogen oxides, carbon oxides, irritating organic vapors
Personal Precautions: Ventilate area, eliminate ignition sources, use personal protective equipment including gloves, goggles, and respirator
Environmental Precautions: Prevent entry into drains, water courses, soil
Spill Cleanup: Absorb spill with inert material (sand, earth), place in chemical waste container. Wash spill area with water.
Methods for Containment: Dike to contain spillage, prevent ground and water contamination
Special Note: Use non-sparking tools for cleanup. Avoid direct contact and inhalation of vapors.
Handling: Keep away from heat, sparks, open flames. Avoid inhaling vapor, mist, or dust. Only handle in well-ventilated places. Wear appropriate PPE.
Storage: Store in tightly sealed original container in a cool, dry, well-ventilated location, away from incompatible materials such as oxidizers and acids.
Hygiene Measures: No eating, drinking, or smoking during use. Wash thoroughly after handling.
Special Considerations: Ground and bond containers during transfer. Protect from static discharge. Keep containers tightly closed.
Exposure Limits: No established OSHA, ACGIH, or NIOSH exposure limits for cis-2,6-dimethylmorpholine. Handle as irritant.
Engineering Controls: Local exhaust ventilation or fume hood
Personal Protective Equipment: Protective nitrile or neoprene gloves, safety goggles or face shield, impervious clothing
Respiratory Protection: Organic vapor respirator if ventilation is insufficient
Other Protection: Eyewash station and safety shower near work station
Monitoring: Airborne concentration monitoring in confined areas
Appearance: Colorless to pale yellow liquid
Odor: Amine-like, mild; may be unpleasant to some
Odor Threshold: Not determined
pH: Weakly alkaline (in solution)
Melting Point/Freezing Point: -50°C (approximate)
Boiling Point: 165-170°C
Flash Point: 52°C (closed cup)
Evaporation Rate: Not determined
Flammability: Flammable liquid
Upper/Lower Explosive Limits: Not determined
Vapor Pressure: 2 mmHg at 20°C
Vapor Density: Heavier than air
Relative Density: 0.89 g/cm³
Solubility: Soluble in water and most organic solvents
Partition Coefficient (n-octanol/water): Not determined
Auto-ignition Temperature: 235°C
Decomposition Temperature: Not available
Viscosity: Not available
Chemical Stability: Stable under recommended storage and handling conditions
Possibility of Hazardous Reactions: Reacts vigorously with strong oxidizing agents, acids
Hazardous Polymerization: Will not occur
Conditions to Avoid: Sources of ignition, heat, direct sunlight, incompatible chemicals
Incompatible Materials: Strong oxidizers, acids, acid chlorides, chloroformates
Decomposition Products: Toxic gases such as nitrogen oxides, carbon monoxide, carbon dioxide
Likely Route of Exposure: Inhalation, ingestion, dermal, ocular
Acute Effects: Irritation of skin, eyes, and respiratory tract. May cause drowsiness, headache, nausea if inhaled or ingested.
Chronic Effects: Repeated or prolonged exposure to vapors could lead to eye, skin, or respiratory tract irritation. No human data for carcinogenicity.
Toxicity Data: Oral-rat LD50: 570 mg/kg (estimated, similar to related morpholines). No data for skin sensitization.
Symptoms: Burning, redness, swelling, coughing, drowsiness, confusion, gastrointestinal distress.
Carcinogenicity: Not classified by IARC, NTP, OSHA.
Mutagenicity: Not tested
Reproductive Effects: No available data
Ecotoxicity: Toxic to aquatic life at larger concentrations. Risk increases if released to surface water or sewerage systems.
Persistence and Degradability: Expected to be readily biodegradable, though removal rate depends on environmental conditions
Bioaccumulation Potential: Not expected to bioaccumulate significantly
Mobility in Soil: Mobile in aqueous environments, low sorption potential
Other Adverse Effects: Avoid uncontrolled environmental release; product may increase biochemical oxygen demand (BOD) in water
Disposal of Product: Incinerate in approved chemical incinerator following local, state, and federal regulations.
Disposal of Packaging: Contaminated packaging should be disposed of as hazardous waste following all regulations.
Sewage Disposal: Avoid disposal into sewers, drains, or natural waterways.
Recommendation: Consult licensed waste disposal contractor for guidance.
UN Number: 3286
UN Proper Shipping Name: Flammable liquid, toxic, n.o.s. (Cis-2,6-Dimethylmorpholine)
Transport Hazard Class: 3 (Flammable liquids), 6.1 (Toxic substances)
Packing Group: III
Environmental Hazards: Not a marine pollutant
Special Precautions for Transport: Keep away from sources of ignition, handle with care, avoid container damage. Emergency guide number for information: ERG 132.
Labels: Flammable liquid, Toxic
OSHA Hazards: Irritant, flammable liquid
TSCA Status: Listed on Toxic Substances Control Act Inventory
SARA Title III: Not subject to reporting under Sections 302, 304, or 313
California Prop 65: Not listed
REACH Status (EU): Subject to registration obligations if imported or manufactured at >1 tonne per year
Inventory Status: Listed in United States, Canada, EU, Australia, and Japan chemical inventories
Other Regulations: Handle in accordance with local, regional, and international chemical safety laws
Workplace Classification: Required labeling and hazard communication in all workplaces handling the substance
