Product Name: Cibenzoline Chemical Name: 4-(2-(2,2-diphenylcyclopropyl)ethyl)-1,4-diazepane CAS Number: 57709-57-0 Recommended Use: Antiarrhythmic pharmaceutical agent Manufacturer: Refer to product supplier Contact Information: Emergency numbers listed by manufacturer SDS Number: MSDS-CBN-001 Synonyms: Cibenazoline, Cibenzoline succinate
Classification: Acute toxicity, Oral (Category 3); Eye irritation (Category 2A); Specific target organ toxicity – Single exposure (Category 2) Signal Word: Warning Hazard Statements: Harmful if swallowed, causes serious eye irritation, may cause organ damage Pictograms: Exclamation mark, Health hazard Routes of Exposure: Inhalation, ingestion, skin and eye contact Symptoms: Nausea, vomiting, dizziness, drowsiness, palpitations Environmental Hazards: Toxic to aquatic life
Cibenzoline (Active Ingredient): 98-100% Chemical Formula: C20H24N2 Impurities/Excipients: Trace amounts of unidentified secondary substances Other Ingredients: None known
Inhalation: Move person to fresh air, keep at rest, seek immediate medical attention if symptoms develop Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if present, seek medical help Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, get medical advice if symptoms persist Ingestion: Do not induce vomiting, rinse mouth with water, seek urgent medical care, provide symptomatic treatment Notes for Physician: Symptomatic and supportive treatment is essential, monitor cardiac function
Suitable Extinguishing Media: Water spray, dry chemical powder, foam, carbon dioxide Unsuitable Extinguishing Media: Strong jets of water Specific Hazards: Emits toxic fumes of nitrogen oxides, carbon oxides on burning Protective Equipment: Self-contained breathing apparatus, chemical-resistant clothing Special Procedures: Cool containers with water spray, avoid inhalation of combustion products
Personal Precautions: Wear gloves, eye protection, laboratory coat, and respiratory protection to prevent exposure Environmental Precautions: Prevent entry into drains, surface water, and soil Cleanup Methods: Sweep up without generating dust, collect into suitable containers for disposal, ventilate area Spill Response: Small spills – collect and place in chemical waste container; large spills – evacuate area and contact emergency services
Handling: Use only in well-ventilated areas, avoid dust generation, do not eat, drink, or smoke during use, wash hands after handling Storage Requirements: Store at 15–30°C in tightly closed original container, away from moisture, light, incompatible substances Incompatibilities: Strong oxidizing agents, acids, bases Precautions: Keep away from food and animal feed, restrict access to authorized personnel only
Control Parameters: No established occupational exposure limits Engineering Controls: Use local exhaust ventilation or fume hood, provide eyewash stations and safety showers Personal Protective Equipment: Chemical-resistant gloves (nitrile), safety glasses with side shields, protective clothing, NIOSH-approved respirator if airborne concentrations are high Hygiene Measures: Change clothing after work, wash hand and face before breaks and after handling
Appearance: White to off-white crystalline powder Odor: Odorless or faint characteristic odor Molecular Weight: 292.42 g/mol Melting Point: 149–153°C Boiling Point: Information not available Solubility: Soluble in organic solvents, sparingly soluble in water pH: Not applicable (insoluble in water) Flash Point: Information not available Density: Information not available Partition Coefficient (log Kow): Not determined
Stability: Stable under normal storage and usage conditions Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide Reactivity: Reactive with strong oxidizers, acids, bases Hazardous Polymerization: Not reported Conditions to Avoid: High heat, open flame, exposure to moisture, strong light
Acute Toxicity: Oral LD50 (rat) 65 mg/kg; can cause central nervous and cardiovascular toxic effects Chronic Effects: Possible effects to heart and nervous system with long-term exposure Skin Irritation: May cause mild irritation Eye Irritation: Causes moderate to severe irritation Respiratory Effects: Inhalation may cause coughing, respiratory discomfort Carcinogenicity: No known carcinogenic effects in humans Reproductive Toxicity: Data insufficient Signs and Symptoms: Nausea, dizziness, headaches, bradycardia, arrhythmia
Ecotoxicity: Toxic to aquatic organisms, may cause long-term adverse effects in aquatic environments Mobility: Low mobility in soil, not readily volatile Persistence and Degradability: Not readily biodegradable Bioaccumulative Potential: Potential for bioaccumulation, no measured data Other Adverse Effects: May affect microorganisms in the environment
Disposal Method: Dispose of as hazardous chemical waste in accordance with local, regional, national, and international regulations Contaminated Packaging: Rinse empty containers before disposal, treat rinsate as hazardous waste Incineration: Preferred method for large quantities, only in facilities compliant with environmental standards Prohibited Disposal: Avoid release to the environment or municipal sewers
UN Number: 2811 (Toxic solid, organic, n.o.s.) UN Proper Shipping Name: Toxic solid, organic, n.o.s. (contains cibenzoline) Transport Hazard Class: 6.1 (Toxic substances) Packing Group: III Marine Pollutant: Yes Special Precautions: Secure packaging, label containers with assigned UN number and hazard class Transport Regulations: Comply with ADR/RID, IMDG, IATA standards
OSHA Status: Not specifically regulated TSCA Status: Not listed WHMIS Classification: D2A (very toxic), D2B (irritant) REACH: Not registered Other Regulations: Subject to local chemical control and hazard communication standards, consult specific jurisdiction for additional restrictions Labeling Requirements: Ensure GHS-compliant hazard, precautionary, and supplementary statements are present
