Product Name: Borane–Morpholine Complex
Synonyms: Borane Morpholine, Borane–Tetrahydro-2H-1,4-oxazine
Chemical Formula: C4H10BNO
CAS Number: 38454-70-7
Recommended Use: Organic synthesis, reducing agent, research applications
Supplier Information: Typically found through chemical reagent distributors; contact information available from safety databases
Emergency Contact: Details found via chemical supplier or institutional safety office
GHS Classification: Flammable liquid, Acute toxicity (oral, dermal, inhalation), Skin and eye irritant, Reproductive toxicant (suspected)
Hazard Statements: Highly flammable, toxic by inhalation and if swallowed, can cause severe burns, possible reproductive hazard
Signal Word: Danger
Precautionary Statements: Avoid breathing dust, vapors, mist; wear protective gloves, clothing, face/eye protection; keep away from heat, sparks, open flames; avoid release to environment
Health Hazards: Burns to skin, eyes, and respiratory tract; central nervous system depression; risk of organ damage from repeated exposure
Environmental Hazards: Harmful to aquatic life; spills lead to groundwater risks
Chemical Identity: Borane—Morpholine complex
Concentration: Typically >95% by weight
Major Components: Morpholine–borane complex (CAS 38454-70-7)
Impurities: Small traces of morpholine (CAS 110-91-8), borane (CAS 7440-42-8)
Stabilizers/Additives: None indicated in standard preparations; always verify with supplier documentation
Inhalation: Move individual to fresh air, keep person comfortable, administer oxygen if breathing is difficult, seek medical attention right away
Skin Contact: Remove contaminated clothing, rinse skin with copious running water for at least 15 minutes, seek emergency help for persistent irritation or burns
Eye Contact: Flush eyes with gentle but large amounts of water for at least 15 minutes, lift eyelids as needed, get immediate medical evaluation
Ingestion: Do not induce vomiting, rinse mouth thoroughly, never give anything by mouth to an unconscious person, get urgent medical assistance
Suitable Extinguishing Media: Dry chemical, carbon dioxide, alcohol-resistant foam, do not use water stream
Unusual Fire Hazards: Borane morpholine releases toxic fumes containing boron oxides, nitrogen oxides, and carbon oxides upon combustion
Protective Equipment: Full protective gear including self-contained breathing apparatus (SCBA), chemical-resistant suit
Special Procedures: Isolate area, remove all ignition sources, evacuate personnel, control runoff to prevent entry into water systems
Personal Precautions: Wear respirator, gloves, goggles, and chemically resistant clothing as appropriate
Emergency Procedures: Remove all sources of ignition, evacuate non-essential personnel, ventilate area
Containment: Prevent further leakage if safe, absorb spill with inert material (sand, vermiculite), collect in suitable closed container
Cleanup: Neutralize residues with dilute acid, collect waste for disposal per local, state, and federal laws
Handling: Use only in well-ventilated chemical fume hoods, ground all equipment, avoid skin and eye contact, prevent buildup of static electricity
Storage Conditions: Keep in tightly closed container, store cool and dry away from direct sunlight, incompatible with oxidizers, acids, bases
Special Requirements: Clearly label containers, limit access to trained personnel, monitor for leaks or corrosion routinely
Exposure Limits: No specific OSHA or ACGIH exposure limits for borane morpholine, but morpholine TLV = 20 ppm (ACGIH)
Engineering Controls: Local exhaust ventilation, fume hood, explosion-proof electrical equipment
Personal Protective Equipment: Chemical splash goggles, impervious gloves, lab coats, closed-toe shoes, organic vapor respirator as needed
Hygiene Measures: Wash hands thoroughly after handling, do not eat, drink, or smoke while working, remove contaminated clothing immediately
Appearance: Colorless to pale yellow liquid (sometimes described as viscous)
Odor: Fishy, ammonia-like
Melting Point: -37 °C
Boiling Point: ~67 °C at 10 mm Hg
Flash Point: 11 °C (Closed cup, varies with preparation)
Solubility: Miscible with ether, alcohols, soluble in common organic solvents
Vapor Pressure: No data for complex, base components suggest low volatility
Density: 0.95–1.01 g/cm3 (approximate, depends on exact ratio)
Partition Coefficient: Not determined for complex
pH: Not applicable; reacts with water
Chemical Stability: Stable under recommended storage, reactive to air and moisture
Conditions to Avoid: Heat, sparks, open flame, moisture, incompatible chemicals (oxidizers, acids, bases)
Incompatible Materials: Strong oxidizing agents, mineral acids, strong bases, water
Hazardous Decomposition Products: Boron oxides, nitrogen oxides, carbon dioxide, hydrogen gas
Polymerization: Not expected to occur under normal conditions
Acute Toxicity: Oral, dermal and inhalation exposures can be severe. LD50 (oral, rat): data limited, but expected to be low due to borane toxicity
Skin Corrosion: Causes severe burns, blisters, dermatitis
Eye Damage: Serious irritation, risk of permanent injury
Inhalation Risks: Irritation to mucous membranes, symptoms of headache, dizziness, nausea, respiratory distress possible
Chronic Exposure: Nervous system and kidney damage reported in repeated animal studies, possible reproductive toxicity
Carcinogenicity: Not listed as human carcinogen by IARC, NTP, or OSHA; chronic effects still being evaluated
Aquatic Toxicity: Harmful to aquatic organisms, bioaccumulates in some fish
Persistence/Degradation: Degrades slowly in water and soil, boron compounds can accumulate
Mobility in Soil: Moderate, risk of reaching groundwater
Other Harms: Toxic to plants, can cause nitrogen and boron imbalance in aquatic systems
Disposal Methods: Follow hazardous waste regulations; incinerate under controlled conditions with flue gas scrubbing
Packaging: Triple rinse empty containers, puncture and dispose by licensed hazardous waste contractor
Contaminated Materials: Collect wipes, gloves, pads in sealed chemical waste bins
Regulatory Controls: Must not discharge to sewer or natural environment
UN Number: 1992
UN Proper Shipping Name: Flammable Liquids, Toxic, N.O.S. (contains Borane Morpholine)
Transport Hazard Class: 3 (Flammable); 6.1 (Toxic substance)
Packing Group: II
DOT/ADR/RID/IATA/IMDG Codes: Classified as dangerous goods, shipping must follow all current regulatory protocols, keep away from oxidizers and acids during transport
TSCA Status: Listed or meets commercial use requirements
SARA 313: Not specifically listed, but check for boron or morpholine reporting
EC Number: 253-049-6
Canadian WHMIS: Class B2 (Flammable), Class D1B (Toxic)
REACH Status: Subject to inventory notification in the EU
Label Requirements: Hazardous chemical label, GHS pictograms for toxic and flammable substances; safety data sheet must accompany shipment
