Product Name: Bis-Piperazine
Chemical Formula: C10H22N4
CAS Number: 25704-18-1
Synonyms: N,N′-Bis(piperazinyl)alkane
Recommended Use: Intermediate for chemical synthesis, pharmaceutical research
Manufacturer: Commercial chemical supplier
Emergency Telephone: Refer to local provider or national poison center
GHS Classification: Skin irritation (Category 2), Serious eye damage (Category 1), Acute toxicity oral (Category 4)
Signal Word: Danger
Hazard Statements: Causes serious eye damage. Harmful if swallowed. Causes skin irritation.
Pictograms: Corrosive, Exclamation mark
Precautionary Statements: Avoid contact with eyes, skin, and clothing. Wash hands thoroughly after handling. Do not eat, drink or smoke when using this product. Wear protective gloves, clothing, and eye/face protection.
Chemical Name: Bis-Piperazine
CAS Number: 25704-18-1
Content: >98%
Impurities: Minimal, unspecified trace process residues
Molecular Weight: 198.31 g/mol
Inhalation: Remove to fresh air. Seek medical attention if symptoms persist.
Skin Contact: Wash thoroughly with soap and water. Remove contaminated clothing. Medical assistance if irritation continues.
Eye Contact: Rinse cautiously with water for several minutes, holding eyelids open. Remove contact lenses if present. Immediate medical attention required.
Ingestion: Rinse mouth with water. Do not induce vomiting. Seek immediate medical help.
Most Important Symptoms: Irritation of respiratory tract, skin redness, severe eye pain, burning sensation in mouth or throat.
Notes to Physician: Treat symptomatically, monitor for delayed effects.
Suitable Extinguishing Media: Foam, carbon dioxide, dry chemical, water spray
Unsuitable Extinguishing Media: Direct jet of water may spread burning material
Specific Hazards: May release toxic fumes of nitrogen oxides and carbon oxides under combustion
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear
Special Procedures: Move containers from fire area if safe. Cool containers with water spray. Prevent fire-fighting runoff from entering drains.
Personal Precautions: Use personal protective equipment including gloves, goggles, and lab coat. Avoid dust formation and breathing vapors.
Environmental Precautions: Prevent spillage from entering drains, sewers, or natural waterways. Notify local authorities as required by regulations.
Methods for Clean-up: Sweep up and shovel material into dry, compatible container for disposal. Ventilate area and wash spill site after clean-up.
Decontamination: Use suitable detergent and water.
Precautions for Safe Handling: Handle in a well-ventilated area. Avoid contact with skin, eyes, and clothing. Practice good hygiene after handling.
Fire/Explosion Prevention: Keep away from sources of ignition. Ground and bond containers during transfer.
Conditions for Safe Storage: Store at room temperature in a cool, dry, well-ventilated place. Keep container tightly closed, clearly labeled, and away from strong oxidizers and acids.
Packaging Materials: Use high-density polyethylene or glass containers to avoid reaction and contamination.
Control Parameters: Occupational exposure limit values have not been established for this material.
Engineering Controls: Use local exhaust or general ventilation to keep airborne levels below recommended limits.
Personal Protective Equipment: Wear chemical-resistant gloves (nitrile), safety goggles, protective clothing, and, when risk of dust or vapor exposure exists, use a NIOSH-approved respirator.
Hygiene Measures: Do not eat, drink or smoke during use. Wash hands before breaks and after work. Remove contaminated clothing and wash before reuse.
Appearance: White to off-white crystalline powder
Odor: Amine-like
Melting Point: 158-162°C
Boiling Point: Not available
Solubility: Soluble in water
pH: Approx. 11 (1% solution in water)
Vapor Pressure: Negligible at room temperature
Density: 1.1-1.2 g/cm³
Partition Coefficient (n-octanol/water): Not determined
Flash Point: >100°C
Flammability: Not easily flammable as a solid
Decomposition Temperature: >200°C
Viscosity: Not applicable (solid)
Chemical Stability: Stable under recommended storage and handling conditions.
Conditions to Avoid: Heat, open flames, moisture exposure, direct sunlight.
Incompatible Materials: Strong oxidizing agents, strong acids, halogenated compounds.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, possible traces of ammonia and other toxic vapors.
Possibility of Hazardous Reactions: No dangerous reactions identified under normal handling. Exothermic reaction possible with strong oxidizers.
Routes of Exposure: Inhalation, ingestion, skin, and eye contact.
Acute Toxicity: Oral LD50 (rat): approx. 500 mg/kg. Data on dermal and inhalation exposure not fully established.
Skin Corrosion/Irritation: Causes moderate to severe irritation, redness, and blistering.
Serious Eye Damage/Irritation: Severe irritation leading to permanent eye damage possible.
Respiratory or Skin Sensitization: May cause allergic reactions after repeated exposure.
STOT - Single Exposure: Possible drowsiness, headaches, or dizziness upon inhalation.
Chronic Effects: Prolonged contact may cause dermatitis or mucous membrane irritation.
Carcinogenicity/Mutagenicity: No data available; not listed in IARC, NTP, or OSHA lists.
Reproductive Toxicity: No specific data available.
Ecotoxicity: Toxic to aquatic life, especially invertebrates and fish. Acute LC50 (Fish): not established.
Persistence and Degradability: Slowly biodegradable in natural environments.
Bioaccumulation: Potential for bioaccumulation low based on structure and physico-chemical properties.
Mobility in Soil: Likely mobile in moist, sandy soils due to solubility in water.
Other Adverse Effects: Avoid release to environment; risk of watercourse contamination and disruption to wastewater treatment.
Disposal Methods: Dispose in accordance with local, regional, and national regulations. Utilize authorized hazardous chemical disposal service.
Packaging Disposal: Triple rinse containers, puncture, and recycle or dispose of as hazardous waste.
Precautions for Disposal: Avoid release into sewer systems or natural environments. Consult environmental authorities for waste classification.
UN Number: Not classified as dangerous goods by UN criteria when shipped in small quantities.
Proper Shipping Name: Amines, solid, n.o.s. (contains Bis-Piperazine)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: III
Label: Corrosive (for bulk shipments)
Marine Pollutant: Not regulated as marine pollutant
Special Precautions for Transport: Ensure containers are secure, upright, and labeled externally.
US TSCA Inventory: Listed
EU REACH Status: Registration or notification may be required
OSHA Hazardous Chemical: Covered under OSHA Hazard Communication Standard
Canada DSL: Listed
WHMIS Classification: D2B (skin/eye irritant)
Other National Inventory Listings: Compliant in several jurisdictions, but users should check specific national regulations.
SARA/Title III: Not subject to reporting requirements.
Proposition 65: No chemicals of concern present
Other Labeling Requirements: Follow country-specific hazardous labeling and documentation procedures.
