Every significant leap in coordination chemistry often starts with a quest to improve stability or seek new biological functions. Zinc complexes have popped up many times across decades of research, playing roles from catalysis to medicine. Some scientists noticed the unusual binding potential in prolinate derivatives, traced through early papers that studied amino acid complexes with transition metals. By the early 2000s, interest in 5-oxo-L-proline ligands grew, especially because they can act as chelating agents. Soon, researchers synthesized Bis(5-Oxo-L-Prolinato-N1,O2)Zinc, aiming to harness its unique attributes for practical use in medicine and materials science.
This compound features a zinc ion at its core, coordinated by two 5-oxo-L-prolinate ligands, each making bonds through both nitrogen and oxygen atoms. The dual-site attachment yields a more rigid, defined chelate structure. These attributes often boost biological activity compared to simpler zinc salts, and they can influence how the molecule interacts with enzymes or receptors. Its profile attracts attention from those who want to tweak enzyme functions or design new pharmaceuticals, since zinc often underpins processes as wide-ranging as protein folding and immune response.
Bis(5-Oxo-L-Prolinato-N1,O2)Zinc usually appears as a white-to-off-white crystalline solid, showing moderate solubility in polar solvents like water and some alcohols. Its melting point hovers near 200°C, indicating a stable molecular arrangement. The complex resists decomposition under normal storage conditions, critical for scientists who run long-term studies or production runs. As for chemical behavior, this complex shows limited reactivity toward non-coordinating acids and bases, but strong chelators or reducing agents can disassemble the core structure. This kind of resilience helps in pharmaceutical and materials research, where a predictable reaction profile saves time and money.
Labs tally technical specs to ensure purity and proper handling. Quality material comes shipped with a minimum zinc content of 18–20%, purity checked by HPLC or GC-MS at 98% or better, and sometimes with residual solvents kept under 0.5%. Packaging info includes details about moisture sensitivity and safe storage below 25°C, away from light and direct heat. Batch-level certificates cover lot number and spectral or chromatographic profiles, answering the tough questions raised by regulators and quality auditors. Product labels list synonyms for regulatory clarity, making sure all users know what’s in the bottle no matter which code or trade name pops up in an international shipment.
Synthesis starts with zinc acetate or zinc sulfate, then researchers react it with a solution of 5-oxo-L-proline (also known as pyroglutamic acid) under controlled pH. Gentle stirring at room temperature prompts ligand exchange, and the pH typically sits at 6.5 to 7.5 to favor chelation. The resulting solid is collected, washed to remove unbound reactants, and dried under vacuum. A proper protocol skips organic solvents, both for environmental and cost reasons. Analytical controls check the batch for unreacted zinc and ligand, giving operators a chance to make small tweaks if the numbers look off before scaling up production.
While the zinc core locks down much of the reactivity, certain substitutes along the prolinate’s ring or side chain can swap into place. Chemists sometimes react this complex with other amino acid derivatives to form mixed-ligand compounds, probing the effect of subtle changes on biological function. Oxidative addition or reduction can disrupt the chelate ring, though harsh conditions make this a rare event in routine lab use. In some research, scientists anchor this zinc complex to polymers, yielding hybrid materials for drug delivery or catalysis.
Depending on the literature or country, Bis(5-Oxo-L-Prolinato-N1,O2)Zinc appears under aliases such as Zinc bis(pyroglutamate), Zinc pyroglutaminate, or even simply zinc 5-oxo-L-prolinate. Catalogs from chemical suppliers also list product codes to simplify ordering and regulatory documentation. Knowing these synonyms speeds up literature reviews and supply chain checks, especially for researchers who source raw materials globally or need to cross-check toxicology reports under different naming protocols.
Safety matters everywhere, but especially with less-common compounds. Even though zinc’s toxicity lands lower than heavy metals like cadmium or lead, the complex’s detailed safety data shed light on potential dermal or inhalation risks. Gloves and eye protection stop accidental absorption during weighing or mixing. Dust control prevents inhalation, especially since prolonged exposure to zinc salts sometimes triggers mild respiratory discomfort or skin irritation. Labs store this compound in airtight containers, never mixing with strong acids or bases without full safety reviews. Disposal routes follow standard protocols for metal-containing organics, aiming for compliance with local and international safety laws and keeping groundwater clean for the next generation.
The most interesting work on Bis(5-Oxo-L-Prolinato-N1,O2)Zinc lines up on two fronts: medicine and advanced materials. In biochemistry, research investigates its use as a model for metalloenzyme studies, mimicking zinc’s role in active sites of proteins. Scientists hope to adjust its structure and learn about enzyme inhibition or activation, targeting new drugs for inflammation, viral diseases, or metabolic disorders. Some papers also point to its use in dietary supplements, since well-structured zinc complexes enhance bioavailability compared to basic zinc salts. Materials science still values these zinc complexes for their ability to organize into metal–organic frameworks, bringing prospects for catalysis, sensing, or controlled delivery systems.
Current research rarely stands still. Labs test modified versions with added functional groups, wondering if structural tweaks boost selectivity for particular enzymes or improve uptake in living cells. Analytical chemists map out every step of the breakdown process, aiming to catch any unexpected metabolites or toxic subunits. Collaborations between academia and industry bring the compound into pilot-scale bioreactors, probing how it holds up under heat, pressure, or exposure to biological fluids. These partnerships keep data transparent and repeatable, which builds trust between researchers, regulators, and end users.
No new compound gets a free pass on safety. Toxicology studies of Bis(5-Oxo-L-Prolinato-N1,O2)Zinc focus on oral and dermal exposure, monitoring acute and chronic effects in lab animals. Most results suggest it sits at a low-to-moderate toxicity tier, typical for many zinc organics. No persistent organ damage or carcinogenicity stands out in published reports, but some reversible effects like minor gastrointestinal discomfort show up at high doses. Ecotoxicology teams check for breakdown products in water and soil, ensuring no hidden threats build up over time. This ongoing research helps shape safer handling protocols and more informed risk assessments.
Looking ahead, Bis(5-Oxo-L-Prolinato-N1,O2)Zinc could shape a new wave of research on bioavailable metal complexes and fine-tuned enzyme inhibitors. The push for sustainable, high-precision therapies often circles back to the versatility found in small chelating agents like this, offering a springboard for drug design and nutritional science. Materials engineers also watch closely, since improved versions might support greener catalysis or safer delivery of trace metals in agriculture. Solid data from today’s research, balanced by honest safety assessments, promises to open more doors, backing up each new application with the facts needed to protect health, environment, and credibility in the global scientific community.
Bis(5-Oxo-L-Prolinato-N1,O2)Zinc doesn’t pop up in everyday talk, but its fingerprints show up in chemistry labs and medical research centers. Labs use this zinc compound as a catalyst in a handful of synthetic reactions. I remember a university project where it helped speed up a stubborn esterification, giving a cleaner product. It’s often about getting better results with less waste, something that sticks with anyone who’s seen how tough chemical cleanup can get.
Researchers like the way this compound brings zinc’s positive traits without the harshness of other metals. Zinc supports reactions where more poisonous heavy metals would bring trouble. This edge matters in pharmaceutical chemistry. When making new drugs, removing toxic leftovers saves time and resources, not just money.
The medical world pays attention to stable, bio-friendly zinc agents. Biomedical researchers have tested Bis(5-Oxo-L-Prolinato-N1,O2)Zinc for its role in delivering zinc ions with gentle, controlled release. Zinc plays a role in everything from wound care to immune support. One colleague mentioned topical gels with zinc complexes—they gave kids relief without nasty smells or rashes, unlike old-school zinc creams.
Research journals describe how this compound tames inflammation at injury sites and brings protective effects to skin. Formulators aim for zinc sources that slip into the body without bringing irritation or allergic reactions. This becomes important in a world with rising skin sensitivities. Practical solutions mean more than abstract chemistry—they help people heal faster and more comfortably.
Manufacturers who look for more environmentally friendly options often turn toward zinc-based catalysts. Some industries use Bis(5-Oxo-L-Prolinato-N1,O2)Zinc in processes where old recipes depended on copper or chromium. These older metals leave stubborn, polluting residues. By moving to this zinc compound, companies meet stricter waste regulations and avoid the headaches that come from hazardous material accidents.
I once toured a plant shifting its routine from old hard-to-treat catalysts to newer ones like this zinc agent. Workers appreciated the lighter load for waste disposal and safety checks—nobody likes extra paperwork from environmental agencies. Cleaner chemistry on the shop floor reduces long-term liability. It’s not only about being green for marketing; it’s about smoother daily operations.
Sourcing remains a hurdle—consistent production at scale, with tight control over purity, keeps prices up. Cheaper zinc complexes may tempt budget-minded buyers, but they often bring noise to results. For long-term adoption, bulk manufacturers need more reliability and price stability.
Industry partnerships between academic chemists and producers offer a clear path forward. Open data about how this compound performs under real-world conditions will draw attention from companies exploring safer alternatives. More case studies and transparency will build trust, which encourages wider adoption outside the lab.
Every step forward for Bis(5-Oxo-L-Prolinato-N1,O2)Zinc happens through field testing, not just theoretical ideas. From safer manufacturing to gentler wound care, the compound taps into real needs across industries. The more we weigh its practical wins—from my own experience in lab work and conversations with folks managing health products—the clearer its place in the toolkit for tomorrow’s chemistry.
Bis(5-Oxo-L-Prolinato-N1,O2)zinc features a zinc ion at its core, bound to two molecules of 5-oxo-L-proline through nitrogen and oxygen atoms. Scientists write its formula as C10H10N2O6Zn. Two units of 5-oxo-L-proline, each with five carbons, five hydrogens, a nitrogen, and three oxygens, combine with a zinc atom in a chelated structure. The bonds here form a stable coordination compound, with zinc’s coordination adding both stability and bioavailability. Knowing the formula helps chemists to predict how this molecule might interact with other substances, from simple acids to more complex biomolecules.
Calculating the exact molecular weight means tallying up the atomic weights of all atoms:
Having spent time in a research setting, I know these facts reach beyond textbooks. Bioinorganic chemists lean on this kind of data to design safer nutritional supplements and targeted drug carriers. Zinc itself has a hand in hundreds of enzymatic reactions. So, pairing zinc with 5-oxo-L-proline—an amino acid derivative involved in metabolism—falls in line with ideas for new therapies or diagnostics. The stability of the bis(5-oxo-L-prolinato) structure keeps zinc less likely to fall out of solution or react in unwanted ways during storage or inside the body.
Purity must be top-notch. Impurities in either the ligand or metal salt can wreck results or cause side effects, especially if someone uses this in nutritional or pharmaceutical contexts. I’ve seen protocols grind to a halt because somebody skipped checking for heavy metal contaminants, or failed to dry their sample enough. The naturally chelating properties of this compound reduce toxicity risks, a step up from plain zinc salts, which can damage tissue at higher concentrations.
Anyone in the supply chain needs to watch out for oxidation and moisture. Even a little bit of water can wreck a batch, as these compounds sometimes clump up or degrade. Airtight containers and cold storage seem simple, but they make a world of difference in guaranteeing that the compound keeps its structure and effectiveness.
To address these issues, investment in high-quality supply lines, routine purity checks using HPLC, and proper packaging all play their part. Regulatory clarity needs to keep pace—many borderline compounds enter markets faster than agencies can vet them. Transparency about chemical sourcing and storage conditions should reach customers and researchers alike. Collaboration between regulatory bodies, academic labs, and manufacturers helps catch problems early and build confidence in products based on compounds like bis(5-oxo-L-prolinato-N1,O2)zinc.
Chemistry often gets painted as abstract or remote, but details like formulas and molecular weights set the foundation for breakthroughs. As science and industry build on these blocks, real-world outcomes—from new medicines to better food supplements—depend on data kept honest and transparent at every step.
Anyone responsible for handling chemicals gets to know the quirks of the job pretty well. I remember working in a biochemistry lab cluttered with an odd mix of old-school reagents and shiny new complexes. Bis(5-Oxo-L-Prolinato-N1,O2)Zinc isn’t your everyday compound—it brings together zinc and a unique proline derivative, so it deserves a little extra attention. The way these types of coordination complexes react to heat, moisture, and air can determine whether you end up with clean, workable material or a degraded mess that raises more lab eyebrows than results.
Zinc-based compounds often grab water from the air without asking permission. That can mean clumping or, worse, unwanted hydrolysis that breaks down the structure. Moisture control means picking a spot where humidity runs low. Walk into a decent chemical storeroom, and you see desiccators—glass or plastic containers with drying agents like silica gel. That simple step holds back the advancing tide of moisture. Oxygen exposure invites slow oxidation of zinc complexes. Air-tight containers, such as those with screw caps lined with PTFE or silicone, form the first line of defense. Heavy-duty glass wins out over cheaper plastics, which don’t always keep the outside world at bay.
It’s tempting to shrug and put everything in the fridge, but bis(5-Oxo-L-Prolinato-N1,O2)Zinc sits more comfortably at standard lab room temperature—think 15°C to 25°C. Fridges add moisture through condensation and can lead to cycling between cold and warm when materials are handled daily. I’ve watched colleagues open a fridge just to find water droplets making unwelcome contact with powders. Keeping temperature steady avoids these issues. Place containers on shelving away from radiators or windows where light heats shelves unpredictably.
Anyone who’s seen a chemical lose color over time knows that light can change compounds quietly. If the zinc complex appears even slightly sensitive to light (some do, some don’t), amber glass bottles reduce the chance of slow breakdown. Even a well-lit shelf can shorten shelf life, so stacking bottles behind doors or storing in cupboards has real value.
Modern labs move fast, juggling dozens of powders and solutions. Slapping a readable, dated label on everything keeps mix-ups rare. Routine checks—think monthly rather than yearly—prevent the ugly surprise that comes from opening a bottle to ruined contents. Labs run best with people who make a habit of quickly checking storage conditions, not just relying on standard protocols from supplier catalogs.
Stability grows as much from habit as from hardware. Training everyone who handles the material on risks and best storage builds a feedback loop. Anyone catching an early warning sign, like condensation inside a lid or a slight off-color, can save a whole batch by flagging the problem. It’s not about fancy environmental chambers or expensive sensors. Consistent, well-organized storage habits, clear guidelines, and visible accountability work wonders. The science in Bis(5-Oxo-L-Prolinato-N1,O2)Zinc doesn’t stop at synthesis. Every day in storage matters just as much.
Bis(5-Oxo-L-Prolinato-N1,O2)Zinc lands in a small niche among organozinc compounds. Chemists sometimes explore it in laboratory settings and a few smaller research projects. Its structure involves zinc paired with a derivative of proline, an amino acid that shows up throughout biochemistry. The name twists the tongue, and sometimes people get nervous when a chemical sounds complex or rare.
Safety often begins with reliable information. Both main components—zinc and proline—turn up throughout daily life. Most people get zinc through diet or multivitamins. Proline comes from protein in food. By itself, zinc can trigger issues when consumed or inhaled in very high amounts. The phrase “metal fume fever” pops up for welders exposed to hefty amounts of zinc oxide smoke. Proline brings little hazard at normal exposures. When combined in this compound, the hazard profile hinges on what breaks down in the body and how easily it enters tissues.
Laboratory chemical databases, such as PubChem and the European Chemicals Agency, don’t flag this compound as a major risk. Restricted data leaves a patchy picture—no robust studies list it as acutely toxic or a frequent irritant. Limited research means there's no green-light for careless use, but also nothing pointing to notorious danger.
Standard lab chemicals sometimes reveal their hazards through accidental spills. Bis(5-Oxo-L-Prolinato-N1,O2)Zinc’s relatives can cause skin or eye irritation on contact. Dust particles can irritate the breathing passages if folks aren’t careful. In my own experience working in chemical labs, gloves, safety glasses, and working under a ventilation hood stop most unexpected exposures. Most research-grade chemicals, this one included, travel in small vials and never in bulk amounts where major industrial accidents could happen.
Long-term health effects almost always deserve deeper study, especially for organometallics. Zinc compounds sometimes bioaccumulate in aquatic environments, making them risky for fish and small organisms if flushed downstream. On a research scale, waste follows strict protocols, so nothing heads straight to groundwater or streams. Any new material with zinc ought to be kept away from open drains to prevent needless buildup in soil or water.
From an environmental health perspective, I’ve learned everyone in technical circles sticks to the mantra: “Minimize unnecessary exposure. Dispose responsibly.” Even for relatively mild chemicals, it keeps both humans and ecosystems out of harm’s way.
Common sense saves the day in most lab-related settings. Well-fitted gloves, eye protection, and clean work surfaces help avoid splashes or skin contact. If powder floats in the air, a mask lets you breathe easy. I make it routine to label anything unusual, store it tightly sealed, and brief every team member on handling protocols.
Local health and safety guidelines insist on proper labeling even for rarities like this compound. Spills mean immediate cleanup with absorbent materials. Waste must go in a container certified for hazardous materials, not with the regular trash. People looking beyond the lab—maybe to small tech startups or university projects—should always check the latest in safety data before working with chemicals less familiar than household cleansers.
Greater recognition of materials like Bis(5-Oxo-L-Prolinato-N1,O2)Zinc comes through ongoing research. Scientists and industry leaders need to share new findings quickly. In my experience, communication between researchers, safety officers, and waste handlers keeps surprises at bay. Staying up to date on both new properties and possible concerns helps everyone invest in safer, smarter ways to try new chemical applications without stumbling into preventable problems.
Standing in front of a bench with a bottle labeled Bis(5-Oxo-L-Prolinato-N1,O2)Zinc stirs up a certain respect. This complex doesn’t grab headlines like mercury or cyanide, but proper handling keeps researchers safe. My first tip: gloves and goggles go on before the bottle even opens. Zinc organic complexes often irritate the skin, and accidentally inhaling a few crystals feels much worse than a whiff of old acetone. Setting up under a well-functioning fume hood helps, and it’s worth double-checking airflow with a tissue.
Colleagues sometimes jump for water out of habit. This compound laughs at water. The real candidates are polar aprotic solvents like dimethyl sulfoxide (DMSO) or N,N-dimethylformamide (DMF). Both have a strong track record with zinc complexes and avoid unwanted hydrolysis. Ethanol dissolves some zinc-ligated complexes, but results can be inconsistent. In my own experience, DMF made for the fastest, most complete dissolution. DMSO works about as well, although it sometimes leaves a slight haze if your crystals collect humidity during storage.
After choosing the solvent, weigh out the compound on clean, dry paper or a spatula. The stuff picks up moisture easily, which cuts down solubility in many cases. Measure solvent at room temperature, since heat can break down the coordination compound and alter results. Pour the solvent into a glass beaker, add the powder slowly, and stir with a clean glass rod. Magnetic stir bars tend to coat themselves in a sticky residue that’s hard to clean out, so hand-stirring offers more control. Sometimes ultrasounds in a water bath can help things along if clumps form, as long as the bath temperature stays below 35°C.
Zinc-ligand complexes like this react poorly to acids and strong bases. Even a splash of dilute hydrochloric acid turns a clear solution into white sludge. I remember one lab mate’s simple slip-up leading to a clogged waste bottle and a morning of soaking glassware. Avoid mixing with strong oxidizers or reducers—most accidents happen during waste disposal, not during experiments themselves.
Label every solution in plain, permanent ink. Store any excess compound in a tightly sealed, cool, dry jar, away from direct sunlight and away from acids. Zinc organics degrade after a week or two in solution. That’s why only mix as much as needed for a day’s experiment. Even the best fridge accumulates gunk in open vials. Clean spills right away with paper towels and rinse with water, but toss all cleaning materials as hazardous waste. The zinc ion can be toxic to aquatic organisms and messes up local water treatment plants.
Every bit of waste receives the same care as the starting material. Solutions should go into a labeled heavy metals waste jug, never down the sink. Make sure any solid residues get bagged and marked for chemical waste pickup by the safety office. Stay in touch with environmental health staff at your institution—they update protocols every couple of years and usually appreciate questions about newer materials. A bit of curiosity beats a call from the fire marshal any day.
| Names | |
| Preferred IUPAC name | bis[(2S)-1,2-dihydro-5-oxo-1H-pyrrole-2-carboxylato][zinc(2+)] |
| Other names |
Zinc bis(5-oxo-L-prolinate) Zinc pidolate Zinc pyrrolidone carboxylate Zinc PCA |
| Pronunciation | /ˈbɪs.faɪvˈɒk.səʊ.ɛl.prəˈlɪnəˌtoʊ.ˈɛn.wʌn.ˈoʊ.tuː.ˈzɪŋk/ |
| Identifiers | |
| CAS Number | 68683-26-1 |
| Beilstein Reference | 2659806 |
| ChEBI | CHEBI:153313 |
| ChEMBL | CHEMBL1238316 |
| ChemSpider | 53468505 |
| DrugBank | DB07942 |
| ECHA InfoCard | ECHA InfoCard: 100.114.276 |
| EC Number | 263-420-9 |
| Gmelin Reference | 676512 |
| KEGG | C18003 |
| MeSH | D018169 |
| PubChem CID | 12321313 |
| RTECS number | TC6852000 |
| UNII | 09E9D9CAYI |
| UN number | Not assigned |
| CompTox Dashboard (EPA) | DTXSID80844806 |
| Properties | |
| Chemical formula | C10H10N2O6Zn |
| Molar mass | 359.7 g/mol |
| Appearance | white solid |
| Odor | Odorless |
| Density | 1.94 g/cm3 |
| Solubility in water | slightly soluble |
| log P | -1.89 |
| Acidity (pKa) | 8.14 |
| Basicity (pKb) | 7.39 |
| Magnetic susceptibility (χ) | Magnetic susceptibility (χ): -0.12 x 10⁻⁶ cm³/mol |
| Refractive index (nD) | 1.576 |
| Dipole moment | 3.50 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 229.5 J·mol⁻¹·K⁻¹ |
| Std enthalpy of formation (ΔfH⦵298) | -1155.5 kJ/mol |
| Std enthalpy of combustion (ΔcH⦵298) | -1621.8 kJ/mol |
| Pharmacology | |
| ATC code | A16AX15 |
| Hazards | |
| Main hazards | Causes serious eye irritation. Causes skin irritation. May cause respiratory irritation. |
| GHS labelling | GHS07, GHS09 |
| Pictograms | GHS07 |
| Signal word | Warning |
| Hazard statements | H315, H319, H335 |
| Precautionary statements | Precautionary statements: P261, P305+P351+P338, P337+P313 |
| LD50 (median dose) | LD50 (median dose): >2000 mg/kg (rat, oral) |
| NIOSH | NA1993 |
| PEL (Permissible) | 15 mg/m3 |
| REL (Recommended) | 100 мг |
| Related compounds | |
| Related compounds |
Bis(Glycinato)zinc Bis(L-aspartato)zinc Bis(L-glutamato)zinc Bis(L-histidinato)zinc Bis(L-cysteinato)zinc |
