Product Name: Amiloride Hydrochloride
Chemical Formula: C6H8ClN7O
CAS Number: 2016-88-8
Synonyms: N-(3-Amino-5,6-dichloropyrazinoyl)guanidine monohydrochloride
EC Number: 217-953-5
Recommended Use: Pharmaceutical applications involving potassium-sparing diuretics
Supplier: Pharmaceutical manufacturers and fine chemical laboratories supply this substance, contact details must always appear on actual lab documentation to support traceability and accountability in safety situations.
Classification: Not classified as hazardous according to GHS criteria. Exposure may cause irritation to the skin, eyes, and respiratory system. Prolonged or repeated contact may intensify irritation.
Physical Hazards: Dust may form explosive mixture with air if finely divided. The powder is combustible under certain conditions.
Health Hazards: May cause mild eye and skin irritation on contact. Swallowing large amounts can trigger abdominal upset, nausea, and possible central nervous system effects. Reports in lab settings mention workers developing headaches or mild dizziness after inhaling airborne dust.
Environmental Hazards: Not classified as environmentally hazardous, but avoid spillage to drains and waterways. Accumulation may pose risk for aquatic species if large volumes enter water sources.
Signal word: Caution
Hazard statements: May cause irritation to eyes, skin, and mucous membranes. Use care to limit airborne dust.
Chemical Name: Amiloride Hydrochloride
Common Names: Amiloride, Midamor
Concentration: 100% active ingredient
Impurities: Pharmaceutical-grade Amiloride Hydrochloride is manufactured with low-level impurities <0.1%.
Molecular Weight: 266.64 g/mol
Structure: Contains a pyrazine ring and a guanidine group, characteristic for potassium-sparing effects.
Eye Contact: Rinse gently under running water for 15 minutes. Keep eyelids open during rinsing. Seek medical attention if irritation persists.
Skin Contact: Wash with plenty of soap and water. Remove contaminated clothing. Wash affected area thoroughly. If rash or discomfort develops, consult a physician.
Inhalation: Move to fresh air. Allow individual to rest in comfortable position. If signs of respiratory distress show, seek prompt medical care.
Ingestion: Rinse mouth with water, spit out, do not induce vomiting unless instructed by medical personnel. Drink water, get medical advice as necessary. Symptoms like nausea or stomach upset may need observation.
Acute Effects: Most lab exposures result in irritation or mild discomfort, but persistent or severe symptoms should be evaluated by clinicians familiar with drug exposures.
Suitable Extinguishing Media: Use dry chemical, foam, CO2, or water spray according to the specific situation and volume involved. For large fires use water spray.
Specific Hazards: The powder and formulated drug will burn, releasing irritating and/or toxic fumes (e.g., nitrogen oxides, hydrochloric acid fumes). Fire can intensify exposures.
Firefighting Procedures: Fire-resistant, protective clothing recommended. Prevent runoff containing residue from entering drains or watercourses.
Special Precautions: Firefighters might need self-contained breathing apparatus to avoid inhaling hazardous smoke.
Personal Precautions: Ventilate area well. Wear respirator, gloves, and protective goggles to avoid inhalation or direct skin/eye contact.
Environmental Precautions: Prevent further leakage, prevent entry into drains and watercourses.
Cleanup Methods: For small spills, sweep with minimal dusting and place in clearly labeled waste container. For larger spills, use vacuum with HEPA filter or dampen waste before sweeping to reduce airborne dust. Wash affected area with plenty of water.
Disposal: Always dispose of residues and cleaning materials in accordance with local, regional, and national environmental regulations. Chemical waste containers labeled correctly reduce the risk of mismanagement and unintentional exposure.
Handling: Handle with care in well-ventilated area. Avoid generating dust. Wear standard laboratory gloves, eye protection, and a dust mask if airborne powder is a concern in your handling setting.
Avoid Contact: Direct skin or eye contact increases risk for irritation. Avoid inhaling fine particles.
Storage: Store in tightly sealed original container. Standard temperature and humidity are safe (15–30°C / 59–86°F) with low humidity preferred. Protect from direct sunlight, strong acids, and strong bases. Keep away from incompatible substances.
Storage Class: Pharmaceutical solid chemicals, non-volatile, stable under normal warehouse conditions.
Control Parameters: No established occupational exposure limits; lab standards recommend minimizing all exposures.
Engineering Measures: Use fume hood or local exhaust to minimize airborne dust.
Personal Protective Equipment: Use safety glasses or goggles, protective gloves resistant to chemicals, and lab coat. Use a dust mask or particulate respirator in dusty conditions.
Hygiene Measures: Wash hands after handling. Avoid eating or drinking in work area. Keep work clothes separated and launder regularly.
Monitoring: Regular surface and air sampling in high-use areas helps confirm controls limit exposure.
Appearance: Pale yellow crystalline powder
Odor: Odorless
pH: 6.0–7.0 (1% aqueous solution)
Melting Point: 332–335°C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Solubility: About 5 mg/mL in water at room temperature. Sparingly soluble in ethanol, acetone, chloroform.
Density: Approximately 1.5 g/cm³
Vapor Pressure: Not measurable under ambient conditions
Form: Stable solid under recommended storage conditions.
Chemical Stability: Stable at room temperature, if kept dry and in closed containers.
Incompatible Materials: Strong acids, strong bases, oxidizers
Hazardous Decomposition: Yields nitrogen oxides, hydrogen chloride under fire conditions or prolonged decomposition.
Polymerization: No dangerous polymerization expected.
Reactivity: No reactivity issues under normal lab conditions.
Acute Toxicity (oral): LD50 values (rat, oral) reported at >500 mg/kg. Mild irritant properties.
Inhalation: Dust may cause upper respiratory tract irritation.
Chronic Exposure: Chronic effects not well documented, but regular or high-level exposure to powdered amiloride may carry cumulative risks.
Skin Irritation: Mild irritant; allergy is rare but possible.
Eye Irritation: Mild transient irritation in animal studies.
Carcinogenicity: No components classified as carcinogenic by IARC, NTP, or OSHA.
Mutagenicity: Negative in standard bacterial assays.
Ecotoxicity: Low likely risk at typical laboratory concentrations, but deliberate disposal into watercourses may interfere with aquatic microflora.
Persistence and Degradability: Highly soluble, expected to biodegrade slowly in soil and water.
Bioaccumulation: Not expected to bioaccumulate, based on molecular structure.
Mobility in Soil: Mobile in both water and soil environments.
Other Adverse Effects: Minimize environmental release through best management practices for pharmaceutical wastes.
Disposal Methods: Place spent material and wastes in approved chemical waste containers. Send only to licensed chemical disposal companies or facilities.
Incineration: High-temperature incineration recommended for pharmaceutical compounds not suitable for water treatment.
Packaging: Ensure containers are labeled with content, hazard, and date before disposal.
Preventative Action: Never allow product to reach natural water systems, landfills, or sewage unless authorized by waste handlers.
UN Number: Not classified as hazardous for transport under UN Model Regulations.
DOT (USA): Not regulated
IMDG/IMO: Not regulated
IATA: Not regulated as dangerous goods
Special Transport Precautions: Securely close containers. Protect from moisture. Store upright during handling to prevent leaks.
Labelling: Ship with appropriate hazard communication for occupational health even if no UN hazard class.
TSCA Status: Listed or exempt
DSL (Canada): Listed
EU Regulation: Complies with EC requirements on chemical safety reports
SARA Title III: Not subject to SARA hazards
OSHA: No specific hazards listed, treat as laboratory chemical
WHMIS Classification: Not controlled
Other Local/Regional: Always follow regional occupational safety and environmental regulations for pharmaceutical products.
