Product Name: Acetyl Pyrazine
Chemical Formula: C6H6N2O
CAS Number: 22047-25-2
Synonyms: 2-Acetylpyrazine, 1-(2-Pyrazinyl)ethanone
Uses: Common in food flavoring, used as fragrance, sometimes found in tobacco products
Manufacturer: Refer to product label or safety documentation provided by the supplier
Emergency Phone: Contact local poison control center or emergency response for hazardous incidents
Recommended Restrictions: Intended for professional, industrial, or laboratory use; not suitable for consumer handling without proper training
Hazard Classification: Eye Irritation (Category 2), Skin Sensitization (Category 1), Acute Toxicity - Oral (Category 4)
GHS Label Elements: Signal word ‘Warning’ with exclamation mark pictogram
Hazard Statements: May cause skin irritation and sensitization; causes serious eye irritation; harmful if swallowed
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, wear protective gear
Symptoms: Redness, tearing, itching in eyes, rash, or possible difficulty swallowing if ingested
Major Hazards: Acute toxicity, risk of allergic skin reaction, irritation to respiratory passages if dust or aerosols produced
Chemical Name: Acetyl Pyrazine
Concentration: >98%
Impurities: Less than 2%; may include other pyrazine derivatives or trace solvents from production
Other Ingredients: No significant nonhazardous components present
OSHA/Hazard Comment: Classified by OSHA as hazardous due to skin/eye irritancy and potential sensitizing effects
Inhalation: Move person to fresh air, provide artificial respiration if breathing has stopped, seek medical attention for difficulty breathing
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with water and mild soap, continue rinsing for several minutes
Eye Contact: Flush with lukewarm water for at least 15 minutes, hold eyelids open, remove contact lenses if present, get immediate medical attention
Ingestion: Do not induce vomiting, rinse mouth with water, get medical advice immediately, monitor for nausea, cramps, or vomiting
Most Important Acute Symptoms: Eye burning, eyelid swelling, skin dryness or blistering, respiratory discomfort
Instructions for Physicians: Symptomatic and supportive care, monitor for signs of allergic reaction or chemical-induced asthma
Flammability: May burn if heated strongly
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, alcohol-resistant foam, water spray (not stream)
Unsuitable Agents: Strong water jet may spread material or fire
Special Hazards from Fire: Combustion produces toxic fumes, especially nitrogen oxides and carbon monoxide
Protective Equipment for Firefighters: Full protective gear, self-contained breathing apparatus
Firefighting Instructions: Cool containers exposed to flames, avoid inhaling smoke, evacuate area as necessary
Personal Precautions: Wear chemical goggles, gloves, protective clothing, and an approved respirator
Environmental Precautions: Prevent spillage from entering drains or sewers; contain with dikes or absorbent material
Cleanup Method: Avoid raising dust, collect with shovel or HEPA vacuum, place in labeled disposal container, ventilate area thoroughly
Decontamination Process: Wash down contaminated surfaces with water and soap; discard cleaning materials properly
Emergency Measures: Evacuate nonessential personnel in event of large spills; alert hazardous materials response if required
Handling: Work in well-ventilated area with fume extraction, keep containers tightly closed, avoid any direct skin or eye contact
Safe Practices: Use protective gear, always wash after handling before eating or drinking, label containers clearly
Storage: Store in cool, dry place away from direct sunlight or incompatible chemicals, maintain secure closure
Incompatibilities: Strong oxidizers, acids or bases can cause hazardous reactions or decomposition
Special Storage Conditions: Isolate from food products and animal feed; keep away from ignition sources
Occupational Exposure Limits: No strict OSHA PEL or ACGIH TLV established; keep exposure as low as feasible
Engineering Controls: Local exhaust ventilation, fume hood, safety eyewash station, and emergency shower
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), splash-proof goggles, laboratory coats, half-mask respirator if dust is generated
Hygiene Measures: Avoid eating, drinking, or smoking in handling areas; change contaminated clothing promptly
General Controls: Monitor air for particles or vapor if large amounts are handled, provide training on chemical hazards
Appearance: Pale yellow to white crystalline powder
Odor: Nutty, roasted, popcorn-like scent
Molecular Weight: 122.13 g/mol
Melting Point: 79–82 °C
Boiling Point: 202–204 °C (at atmospheric pressure)
Solubility: Slightly soluble in water, easily dissolved in organic solvents (ethanol, ether)
pH: Not applicable for solid
Vapor Pressure: Very low at room temperature
Flash Point: About 92 °C (closed cup)
Odor Threshold: Detectable at very low concentrations due to its strong aroma
Chemical Stability: Remains stable under normal storage conditions
Hazardous Polymerization: No risk of polymerizing spontaneously
Conditions to Avoid: High temperatures, open flames, strong oxidizing conditions
Material Incompatibility: Avoid contact with concentrated acids, alkalis, and oxidants
Hazardous Decomposition: Burns to release carbon monoxide, carbon dioxide, nitrogen oxides
Sensitivity: Not especially sensitive to shock or static electricity
Acute Toxicity: Harmful when swallowed in large amounts; LD50 (rat, oral): approx. 670 mg/kg
Irritation: Causes moderate to severe eye irritation, mild transient skin irritation
Sensitization: Possible skin allergen with repeated handling
Chronic Exposure: No long-term toxicity reports, but chronic skin contact may enhance allergic responses
Carcinogenicity/Mutagenicity: No confirmed cancer risk or mutagenicity according to current data
Other Health Effects: Inhalation of dust may irritate respiratory tract, symptoms may include sore throat or coughing
Aquatic Toxicity: Not acutely toxic to aquatic life at common environmental concentrations
Mobility: Moderate soil mobility if spilled; slow evaporation
Persistence and Degradability: Biodegradable, unlikely to accumulate significantly in environment
Bioaccumulation Potential: Low; breaks down rapidly in soil and water
Ecotoxicity Data: Very limited information, avoid large-scale release
Precaution for Environment: Prevent contamination of surface water, drains, and soil in bulk situations
Disposal Methods: Handle as hazardous chemical waste; collect in sealed containers labeled for incineration
Regulatory Waste Codes: Dispose according to local, regional, or national legislation for hazardous chemical waste
Recycling/Reuse: Not appropriate for recycling, minimize disposal by purchasing only as much as needed
Contaminated Packaging: Rinse empty containers, offer for recycling if possible or dispose of as hazardous waste
UN Number: Not assigned
UN Proper Shipping Name: Not regulated as dangerous for most forms of ground or air shipment
Transport Hazard Classes: Not classified as hazardous under main international conventions
Packing Group: Not applicable
Special Precautions: Prevent package leaks, label clearly, avoid exposure of shipments to extreme temperatures
Bulk Transport: Protect large containers from moisture; monitor for accidental tipping or puncture in transport
US Regulations: TSCA inventory listed, not considered hazardous for transport; reportable under SARA Title III if large quantities released
EU Regulations: REACH-registered, listed in Annex I; subject to hazard and precautionary labeling
Other Regions: Check national inventory status for non-US/EU jurisdictions
Label Requirements: Display pictograms for eye/skin irritation and acute toxicity; include hazard and precautionary phrase codes
Worker Safety: Comply with OSHA HazCom Standard, ensure safety data sheet is accessible in all workplaces
