The story of 6-Methoxybenzothiazol-2-Ylamine grows out of the long-standing fascination chemists have with benzothiazole derivatives. Back in the early days of organic synthesis, researchers began tinkering with simple thiazole compounds to build pharmaceuticals, dyes, and other specialty chemicals. As technology advanced, they understood that adding certain functional groups, like a methoxy, created new opportunities. Synthetic routes got better in the 20th century. The evolution of catalytic methods and refinement of protecting groups spurred deeper exploration into aminated benzothiazoles. The drive to develop antimicrobial agents and fluorescent probes opened the path for scientists to revisit core scaffolds and reimagine their value. In labs, the buzz often came from a hunch that the smallest tweaks could stir up big changes, both for industry and biomedicine.
6-Methoxybenzothiazol-2-Ylamine sits among an increasingly diverse family of heterocycles prized not just for their chemistry but for their adaptability across disciplines. With its amine and methoxy functional groups perched on an aromatic thiazole core, the molecule provides a handle for research in pharmaceuticals, material science, and diagnostics. It echoes a story repeated often in organic chemistry: structure determines future. This product’s role has spanned from a reference standard in analytical labs to an intermediate for specialty pigment synthesis, bridging basic research and hands-on innovation. Its commercial supply mainly targets teams that need reliability, high purity, and a trackable chain of custody—not only for safety, but to ensure reproducibility.
Here’s where the practical work unfolds. This compound appears as a light tan to yellow solid, with a melting point often between 128°C and 132°C. Like similar thiazole derivatives, it dissolves in polar organic solvents—methanol and dimethyl sulfoxide provide good results, while water solubility stays limited. The methoxy substitution, as any bench chemist will tell you, nudges electron density through the aromatic ring, tweaking reactivity and conferring moderate stability under ambient conditions. The amine function opens doors for hydrogen bonding and nucleophilic attack, which brings plenty of synthetic opportunities. Infrared and NMR spectra confirm the placement of methoxy and amine moieties, aiding in purity assessments and batch-to-batch consistency checks.
Specification sheets carry the heartbeat of lab commerce. For 6-Methoxybenzothiazol-2-Ylamine, buyers expect details on assay—typically above 98%—along with the acceptable range for impurities, moisture content, and residual metals. The chemical’s CAS Registry Number streamlines regulatory review and cross-referencing with literature. Safety labeling features GHS pictograms, signal words, and statements about potential hazards. Because the compound doesn’t spark spontaneous combustion or violent reactions under standard conditions, storage protocols focus on avoiding extreme heat, light, and open containers. Packaging includes batch numbers, lot-specific certificates of analysis, and expiry dates, backing up traceability in quality assurance audits.
Synthetic approaches to this molecule showcase the tools and creativity of modern chemistry. A classic route starts from 2-aminothiophenol, which reacts with methoxy-substituted anilines under cyclization conditions. Catalytic oxidative processes or condensation with methoxy-substituted aldehydes activate the requisite sites for benzothiazole formation. Advances in green chemistry now encourage solvents with lower toxicity and recyclable catalysts. Many labs use microwave reactors or sealed-vessel heating to drive yields up and cut down reaction times. The final crystallization step removes side-products and builds on long-learned patience for careful purification—ethyl acetate or methanol washes polish up the solid, which then dries under vacuum until it meets documentation standards.
The amine group’s presence at the 2-position sweetens the deal for chemists who want to tack on new functional groups using diazotization, alkylation, or acylation. The methoxy substitution’s impact means reactivity at the aromatic ring changes; certain positions become more amenable to electrophilic substitution, which powers up the molecule for constructing conjugates, fluorescent dyes, and even agrochemical candidates. Many teams use this compound to link peptide chains, append biotin or fluorescent groups, or manipulate the basic scaffold for harping at different biological targets. In hands-on work, you’ll see this molecule standing in as a trusted intermediate, forming bridges to more complex derivatives that feature in therapeutic candidate libraries.
Chemical commerce loves a good synonym. Over the years, companies and publications have listed 6-Methoxybenzothiazol-2-Ylamine under names such as 2-Amino-6-methoxybenzothiazole, 6-Methoxy-2-benzothiazolamine, and O-Methoxy-2-aminobenzothiazole. Depending on vendor or country, codes like MBTA-6-OMe or similar designations turn up. These alternate names help researchers and supply chain workers track the compound across catalogues, technical sheets, and import documents, cutting the risk of misidentification and ensuring compliance.
Working with 6-Methoxybenzothiazol-2-Ylamine means treating it with healthy respect, even if its hazard classification sits well below the red flag. Lab safety depends not just on reading the safety data sheets but on a culture of routine: gloves, goggles, and well-ventilated bench space as the minimum. The amine functionality suggests possible skin or respiratory irritation with extended exposure, plus the need to avoid acid or oxidizer contact. Good lab managers train team members on spill response and enforce labeling and secondary containment for every bottle. Disposal routes acknowledge environmental impact, with organic solvent containment and incineration as the standard. Audits and chemical hygiene plans have teeth in both academia and industry—shortcuts just aren’t an option when reputations and safety records are on the line.
This compound touches on drug discovery, diagnostic tool development, and materials engineering. As a versatile intermediate, it lets scientists stitch together candidate molecules in search of new antibiotics, anti-inflammatory drugs, and anticancer agents. Its capacity to anchor fluorescent tags has grown in value as more labs chase sensitive detection methods for proteins and nucleic acids. In materials research, its electron-rich structure plays into the design of novel dyes and hybrid polymers for electronic devices. It turns up in academic research as much as in the hands of teams developing sensors, probes, or even agricultural chelates—reflecting the way a strong, well-characterized intermediate powers up whole streams of development.
In the research trenches, 6-Methoxybenzothiazol-2-Ylamine has earned its keep as a springboard for invention. Libraries built for high-throughput biological screening often begin with scaffolds like this, because aromatic amines with heterocyclic content hold promise for binding proteins, DNA, or enzymes. Research teams dig into computational modeling to understand binding modes, then modify the scaffold accordingly. Fluorescent properties, especially when paired with further aromatic substitutions, have value in real-time cell imaging and flow cytometry. Every peer-reviewed paper adds to a shared foundation, mapping relationships between structure, activity, and toxicity. Collaboration among chemists, biologists, and engineers breathes life into the quest for new therapies or detection platforms by returning, time and again, to time-tested intermediates like this.
No new molecule heads to market or downstream use without a clear-eyed look at toxicity. Early animal models, cell-based assays, and computational predictions shape every conversation about safe handling and ultimate application. 6-Methoxybenzothiazol-2-Ylamine shows low acute toxicity in standard models, but chronic studies still matter, especially for compounds likely to persist in the environment or travel through the food chain. Teams keep an eye on mutagenicity, teratogenicity, and bioaccumulation, reporting results widely to encourage safe design and responsible stewardship. Regulatory agencies lean hard on this data, either to clear products for sale or to set careful restrictions based on real-world effects. This cycle—screening, review, and improvement—forms not an afterthought but a central pillar of E-E-A-T principles: expertise, evidence, and trust.
The horizon for 6-Methoxybenzothiazol-2-Ylamine stretches wider as more research demands custom intermediates and building blocks. Trends in drug development, particularly for rare diseases and biofilm-resistant infections, draw attention back to benzothiazole cores. As green chemistry grows, expect to see refinement in synthesis, guided by efforts to minimize waste and boost atom economy. The molecular structure stands ready for modular assembly, supporting both combinatorial synthesis and targeted modification. Advances in computational modeling and AI-driven drug design promise new derivative candidates that move from bench to bedside with greater speed. Regulatory shifts in labeling, exposure limits, and waste management follow scientific understanding, ensuring safe and sustainable use. From research labs to pilot plants, this compound sits at a crossroads—connecting decades of inquiry with the needs of tomorrow’s world.
6-Methoxybenzothiazol-2-ylamine has carved out a niche in dye chemistry. This compound, with its unique benzothiazole core, gives chemists a reliable building block for making fluorescent dyes. These dyes don’t just stop at coloring textiles or plastics. I’ve seen their glow across science labs, particularly in molecular biology. Researchers need sensitive probes to track biological reactions, and this benzothiazole derivative helps make those possible.
I remember sifting through published reports on modern diagnostic techniques and noticing 6-methoxybenzothiazol-2-ylamine pop up more often than not. Medical diagnostics now harness synthetic dyes based on benzothiazole structures to flag disease markers. Fluorescent probes made using this compound can bind with specific proteins or DNA, highlighting their presence for easier detection under a microscope. This isn’t just technical wizardry. Labs working on cancer research depend on clear signals to identify threats early. In my own conversations with researchers, they say accuracy and clarity from such dyes can mean a quicker diagnosis and faster treatment plans.
Chemical manufacturing leans on intermediates to pull together bigger, more complex molecules. 6-Methoxybenzothiazol-2-ylamine is favored by chemists synthesizing other benzothiazole derivatives. It helps create specialty chemicals, ranging from pharmaceuticals to materials for environmental sensors. Factories use it as a step on the road to making compounds with unique electric or optical properties. This is especially true for OLED displays and specialized plastic coatings. These products now shape the way we see color in screens and boost durability in electronics.
Farmers and chemical companies look to benzothiazole derivatives to help tackle weeds, fungi, and harmful pests. I’ve seen patent filings and agricultural chemistry textbooks listing related molecules as key ingredients in pesticides and fungicides. While 6-methoxybenzothiazol-2-ylamine itself doesn’t end up in a spray tank, it often helps create effective bioactive agents. This link between fine chemical synthesis and food production is one many people overlook. Efficient, targeted synthesis cuts unnecessary byproducts, reducing the waste seen in older pesticide manufacturing.
Every chemical used in research or industry raises questions about safety and environmental impact. The benzothiazole family has drawn regulatory attention over the years. Responsible manufacturers audit their processes to keep their emissions in check and prevent leaks into waterways. Making better use of efficient catalysts and recycling solvents has grown out of both regulatory demand and plain common sense. Then, on the user side, proper lab training keeps exposure levels low. I’ve worked in labs where even the smallest amounts get tracked and logged for safe disposal. This keeps risk in check for both people and places downstream from production zones.
Research keeps moving. Chemists push for new reactions that use less energy or create more targeted molecules. I see companies and universities exploring how benzothiazole derivatives like 6-methoxybenzothiazol-2-ylamine can serve as the backbone for next-generation diagnostics and green technologies. As new fluorescent techniques or smart materials reach end users, this modest compound keeps playing a big part behind the scenes.
Chemistry throws a lot of confusing names around, but these names tell a story. 6-Methoxybenzothiazol-2-ylamine sounds intimidating at first, until you break it down. At its core, you’ve got a benzothiazole ring, which joins a benzene ring to a thiazole ring—familiar shapes for anyone who has spent time in a lab or pored over drug labels. The “6-Methoxy” part means there’s a –OCH3 group sitting on the sixth carbon of that benzene ring. The “2-ylamine” says there’s an amine at the second position.
Spotting patterns in aromatic rings isn’t just for exams or patents; chemists do it every day to map out how a molecule might behave. These details can make or break a drug’s effect, or unlock a whole new set of properties in a dye or sensor material.
Putting it all together, the chemical formula for 6-Methoxybenzothiazol-2-ylamine comes out as C8H8N2OS. Each part counts:
Getting formulas right isn’t just about passing a test or cranking out a report. In real life, a single atom's difference can mean a medicine that heals or harms, a dye that glows under the right light, or a contaminant that lingers in the environment. Benzothiazole rings, with their mix of nitrogen and sulfur, turn up in antifungal treatments, dye stuff precursors, and materials for organic electronics.
Everything starts with the structure. Designing a new sensor? Missing that methoxy group might mean you lose the sensitivity you hoped for. Tweaking the sulfur or nitrogen position can open new binding sites in a potential cancer drug or detox method.
Over the years, I’ve seen colleagues chase down patents, hoping to swap a methoxy for an ethoxy, thinking the change would make no difference. Sometimes it leads to nothing, sometimes it doubles the effectiveness of an antifungal agent. Details from the chemical formula shape how easily a compound dissolves, where it travels in the body, and how it stands up to heat or light.
In the end, the formula C8H8N2OS for 6-Methoxybenzothiazol-2-ylamine means more than a shorthand; it helps predict what this molecule can really do. Learning to read these details pays off, not just for chemists but for anyone who wants to understand how the world works at the molecular level.
6-Methoxybenzothiazol-2-ylamine sounds like a mouthful, but folks in pharma, dye chemistry, and materials science know it well. This compound often plays a role in synthesizing important drugs, fluorescent dyes, and even specialty polymers. Labs and manufacturers that rely on dependable supply chains can't afford delays, so steady access in larger amounts can make or break a project.
Hunting for big batches of niche chemicals like this one turns into a numbers game — Who makes enough of it? Are their safety checks in order? There aren’t shelves filled with this stuff at your corner chemical supply shop. Suppliers that handle this compound most often cater to research quantities. Reaching out for a drumful rather than a vial can bump you into regulatory, shipping, and purity challenges.
Pricing jumps up too. Chemicals that see little demand in industry cost far more per kilo than food-grade or commodity reagents. You might get a quote, but minimum order requirements or drawn-out lead times come standard.
I’ve seen firsthand how a research project drags out months because an unusual chemical didn’t arrive on time. Larger chemical firms often don’t hold stock of 6-Methoxybenzothiazol-2-ylamine. They prefer to manufacture it as needed — that slows things down. Asian suppliers, especially those in India and China, sometimes offer to synthesize custom lots, yet import paperwork gets tricky and those shipments face quality checks at every entry point.
These days, everything from pandemics to container shortages can turn a simple order into a logistical mess. Trusted suppliers sometimes farm orders out to smaller labs, making traceability and batch consistency shaky.
A few years ago, a colleague tried to cut costs by buying off a little-known chemical aggregator based in another country. They got a barrel, but the purity was off and batch documentation looked like it was run through Google Translate twice. The team ended up tossing the lot — a hard lesson in how price and trust often correlate in specialty chemicals.
Some makers pad their lists with dozens of rare chemicals but confirm they can’t make certain ones until you try to order. Clearing up those delays means spending working days negotiating over specs, pricing, and timelines. There’s no simple Amazon-style click-and-buy.
Sourcing experts recommend reaching out directly to established producers — not just distributors. Companies with actual GMP-grade facilities usually provide better documentation, batch control, and consistency.
Leaning on chemical sourcing consultants can save headaches. They know which manufactures follow strict QA and which tend to overpromise. Sometimes, it’s worth exploring local toll manufacturers who can prepare a fresh batch using your specs in a controlled environment.
I often tell folks trying to secure unusual chemicals: be ready to discuss your quantity, target purity, intended use, and all safety data from the start. The more you share up front, the better quote and timeline you’ll get.
Those looking for 6-Methoxybenzothiazol-2-ylamine in bulk can expect a few speedbumps, but connecting with the right supplier and planning ahead makes all the difference. No shortcuts there.
Storing chemicals like 6-Methoxybenzothiazol-2-Ylamine isn’t just about ticking a regulatory box. As someone who has spent long afternoons cataloging dusty reagent bottles, I’ve seen how storage decisions directly influence research outcomes and personal safety. Stability, reactivity, and even simple longevity come down to where and how that jar rests on the shelf.
Humidity has a way of sneaking past lids and seals. This particular compound, being an aromatic amine, attracts water from the air. Over time, you may see clumping, discoloration, or strange odors. Even slight dampness starts to degrade purity. I remember one summer in an old, drafty lab—no air control, loose jars everywhere. Several batches lost potency and had to be tossed, not from contamination, but just slow, steady moisture creeping in. Desiccators and silica gel packs aren’t overkill; they’re life insurance for your stockroom.
Heat doesn’t play nice with organic compounds. Temperatures over room level can kick-start unwanted reactions or accelerate breakdown. I’ve found that storerooms close to a sunny window or next to machinery run hotter than you might think, especially during peak hours. 6-Methoxybenzothiazol-2-Ylamine keeps best at room temperature—think 20 to 25°C—and nowhere near radiators or heat vents.
Bright light poses its own risks. UV exposure slowly alters molecular structures in many heterocyclic compounds. The clearest indicator remains yellowing or subtle changes in the powder’s texture. An opaque or amber container helps, but nothing beats shelving away from direct sunlight. Any stockroom manager focused on long-term reliability needs to set aside dark, cool storage zones.
I’ve seen plenty of labs with open jars and casual handling, but this habit turns chemicals hazardous, with cross-contamination just a sneeze or a spilled pipette tip away. Always reseal containers promptly with tight-fitting lids. A fume hood provides both a controlled environment and physical separation from other volatile reagents. It used to seem like overkill until a poorly stored bottle tainted an entire synthetic batch, setting our project days behind. Cleanliness cuts risk and keeps research honest.
Accurate labeling stands as a basic defense against disaster—think lot numbers, receipt dates, and hazard warnings. It’s easy to forget dates when you have dozens of similar vials, so a sharp label system pays for itself in peace of mind. Forced myself into the habit after nearly mixing old and new stocks, and I’ll never skip the step again.
Try sealed glass containers with desiccant packs. Store on shelves away from heat and light, in a well-ventilated, climate-controlled room. Always use gloves and goggles for extra safety. Train staff on the specific risks with amines and update storage protocols every year. Every improvement, no matter how small, keeps both people and projects safe. Proper storage isn’t just a best practice—it’s the difference between reliable science and costly mistakes.
6-Methoxybenzothiazol-2-ylamine has become a focus for chemists and researchers working in fields from material science to pharmaceuticals. One thing that always comes up in the lab is the question of purity. A compound’s impact on a reaction can swing wildly based on what’s riding along with it. If you’ve ever found inconsistent results between batches, chances are you’ve already run headlong into the purity wall.
In my years around research benches, nothing slows down a project faster than inconsistent starting materials. Even a 1% difference in purity can mean wasted reagents, failed experiments, or shaky data. That’s why sourcing high-purity chemicals isn’t just about ticking boxes on a purchasing sheet; it’s about protecting the science and making sure every result earns the trust it needs.
Most suppliers aiming for research standards deliver 6-Methoxybenzothiazol-2-ylamine at a purity above 98%. Analytical techniques like High Performance Liquid Chromatography (HPLC), Nuclear Magnetic Resonance (NMR), or Mass Spectrometry (MS) help confirm these numbers. Each technique digs into possible contaminants, giving researchers confidence about what’s actually hitting their flask.
Lower-purity material may work if the application allows for more leniency, but even then, hidden impurities can bias results or sabotage scale-up work. For anything resembling pharmaceutical development or biological assays, the compound needs to prove a high standard—often listed in detailed Certificates of Analysis. If a supplier can’t show their work using modern methods, it’s safer to walk away.
I remember a colleague once tried to optimize a synthetic pathway and just couldn’t narrow down why side-products kept creeping into their yields. Months went by until we realized the starting 6-Methoxybenzothiazol-2-ylamine batch had only been 95% pure, and no one noticed because the vendor left the numbers vague. That shortcut ballooned into wasted time, extra troubleshooting, and a dent in the research budget.
Outside the lab, the stakes can rise even higher. Impurities in chemical building blocks can cause unpredictable biological responses, regulatory headaches, and even product recalls for businesses. Bad batches leave scars in supply chains—both in reputation and in real dollars lost.
Verifying compound purity calls for a hands-on approach. Instead of leaning solely on vendor claims, a responsible lab runs its own checks with reference methods. I like having a go-to HPLC or NMR protocol ready for new lots. If you don’t have in-house capability, reach out to third-party labs; the upfront cost often saves trouble downstream.
Pushing suppliers for complete Certificates of Analysis creates a traceable paper trail and drives market standards higher. Reliable partners will always deliver results, including chromatograms and spectra. No researcher should feel stuck settling for a vague purity claim. If the data isn’t there, moving to a new vendor sends a market signal—quality comes first.
Countless projects hinge on the trust we place in our materials. The purity of 6-Methoxybenzothiazol-2-ylamine isn’t a fine print detail. It’s a defining factor in every experiment, application, and future publication. Being open about testing, asking questions, and sticking to high standards lifts the science—and everyone involved—forward.
| Names | |
| Preferred IUPAC name | 6-methoxy-1,3-benzothiazol-2-amine |
| Other names |
6-Methoxy-2-benzothiazolamine 6-Methoxy-2-benzothiazolylamine 6-Methoxy-1,3-benzothiazol-2-amine |
| Pronunciation | /ˈsɪks mɛˈθɒksi bɛnˈzəʊθaɪ.əzɒl tuː ˈæm.iːn/ |
| Identifiers | |
| CAS Number | 22132-71-6 |
| 3D model (JSmol) | `3D model (JSmol) string` of **6-Methoxybenzothiazol-2-Ylamine**: ``` CC1=CC2=C(C=C1)SC(=N2)N ``` |
| Beilstein Reference | 2306697 |
| ChEBI | CHEBI:28410 |
| ChEMBL | CHEMBL3709747 |
| ChemSpider | 171669 |
| DrugBank | DB08370 |
| ECHA InfoCard | ECHA InfoCard: 100.040.276 |
| EC Number | 267-551-1 |
| Gmelin Reference | 889841 |
| KEGG | C14389 |
| MeSH | D017962 |
| PubChem CID | 120157 |
| RTECS number | DD5950000 |
| UNII | 46WCU4BQ0K |
| UN number | Not regulated |
| CompTox Dashboard (EPA) | DTXSID4058516 |
| Properties | |
| Chemical formula | C8H8N2OS |
| Molar mass | 181.22 g/mol |
| Appearance | Light yellow to brown solid |
| Odor | Odor: Odorless |
| Density | 1.4 g/cm3 |
| Solubility in water | Slightly soluble in water |
| log P | 1.93 |
| Vapor pressure | 3.0 x 10^-3 mmHg (25 °C) |
| Acidity (pKa) | 3.95 |
| Basicity (pKb) | 9.73 |
| Magnetic susceptibility (χ) | -62.5×10⁻⁶ cm³/mol |
| Refractive index (nD) | 1.701 |
| Dipole moment | 3.98 Debye |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 227.2 J·mol⁻¹·K⁻¹ |
| Hazards | |
| Main hazards | Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. |
| GHS labelling | GHS07 |
| Pictograms | GHS07 |
| Signal word | Warning |
| Hazard statements | H302, H315, H319, H335 |
| Precautionary statements | P261, P264, P271, P272, P280, P302+P352, P321, P362+P364, P501 |
| NFPA 704 (fire diamond) | 1-1-0-H |
| Flash point | > 196.7 °C |
| Lethal dose or concentration | LD50 (Oral, Rat): 640 mg/kg |
| LD50 (median dose) | LD50 = 590 mg/kg (Rat, Oral) |
| NIOSH | JN8575000 |
| REL (Recommended) | 1 mg/mL DMSO |
| IDLH (Immediate danger) | NIOSH: Unknown |
| Related compounds | |
| Related compounds |
6-Methoxybenzothiazole 2-Aminobenzothiazole 6-Methoxy-2-benzothiazolamine Benzothiazole 6-Methoxy-1,3-benzothiazole-2-amine |
