Product Name: 5-Nitrothiazol-2-Ylamine
Synonyms: 2-Amino-5-nitrothiazole
Catalog Number: N/A
Molecular Formula: C3H3N3O2S
Molecular Weight: 145.14 g/mol
Recommended Use: Laboratory research and chemical synthesis
Manufacturer: Information available upon request from supplier
Emergency Phone Number: Local poison control or emergency health services
Address: Company registered location or chemical supplier facility
Email: Contact via supplier-specific details
GHS Classification: Acute toxicity category 4 (oral), Eye irritation category 2A, Skin irritation category 2
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin irritation, causes serious eye irritation
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid inhaling dust, wash thoroughly after handling, wear protective gloves and eye/face protection, not for human or animal consumption
Potential Health Effects: Inhalation or ingestion can lead to respiratory irritation, digestive upset, CNS symptoms; skin and eye contact can provoke redness, burning or swelling
Target Organs: Liver, kidneys, mucous membranes
Emergency Overview: Yellow to orange powder, delivers sharp chemical odor, typically presents a combustible dust risk in large quantities
Chemical Name: 5-Nitrothiazol-2-Ylamine
CAS Number: 121-66-4
Content/Concentration: ≥98% by weight
Impurities: Trace amounts of related thiazole compounds, nitro derivatives (generally <2%)
Other Identifiers: EINECS 204-480-5
Hazardous Components: Product contains only one primary hazardous chemical per listed composition
Inhalation: Move the person to fresh air immediately, provide oxygen or artificial respiration if breathing becomes difficult; contact medical services if symptoms persist
Eye Contact: Rinse eyes slowly and gently with cool water for at least 15 minutes, making sure eyelids are open, remove contact lenses after first few minutes and continue rinsing
Skin Contact: Remove contaminated clothing, rinse affected skin under flowing water, wash thoroughly with mild soap, seek professional treatment for lingering symptoms or irritation
Ingestion: Rinse mouth with water, do not induce vomiting, drink small sips of water if possible, monitor for abdominal pain or nausea, seek prompt medical advice, and provide SDS to responders
Most Important Symptoms and Effects: May cause headaches, dizziness, skin or eye irritation, and, in large amounts, liver or kidney effects
Medical Attention: Immediate support strongly advised for significant exposure by any route
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, water spray for small fires; use water fog for larger scale
Unsuitable Methods: Direct water streams on dusts can cause spreading
Specific Hazards: Product dust or fine particulates can become explosive, thermal decomposition emits toxic nitrogen oxides, sulfur oxides, carbon monoxide
Firefighter Protection: Self-contained breathing apparatus, chemical-resistant suit, gloves, and boots
Combustion Products: Oxides of nitrogen and sulfur; possible ammonia and cyanide derivatives
Special Equipment/Precautions: Avoid inhalation of smoke, prevent runoff from entering waterways, cool containers at risk of overheating with water mist
Flash Point: Data not available; assume moderate-level flammability
Personal Precautions: Wear full-face respirator, chemical-resistant gloves, impermeable suit, and eye protection, keep unnecessary personnel clear of area
Environmental Precautions: Prevent product from entering drains, surface water, or soil; block off spill area to restrict product migration
Methods for Cleanup: Sweep up powder or absorb solutions with inert material (sand, vermiculite), place in sealed chemical waste container for disposal, ventilate area thoroughly
Decontamination: Clean spill area with damp mop or towel; avoid raising dust; dispose cleaning materials as hazardous waste
Waste Disposal: Refer to local, regional, and national guidelines; avoid sending to landfill in untreated state
Safe Handling: Only open containers in a fume hood or well-ventilated area, minimize direct exposure and dust formation, keep away from heat sources, sparks, and open flames, do not eat, drink, or smoke in areas where chemicals are handled, maintain hygiene by washing hands and changing contaminated clothing promptly
Handling Tools: Use grounded equipment, non-sparking tools when transferring powder, and secondary containment trays for working with bulk quantities
Storage Conditions: Store in tightly closed original container, keep in a cool, dry, well-ventilated location, segregate from strong oxidizers, acids or reducing agents, avoid exposure to direct light and moisture
Container Requirements: Use compatible, labeled containers with chemical-resistant seals or lining, periodically inspect for damage or leakage
Occupational Exposure Limits: No established ACGIH, NIOSH, or OSHA exposure limits; recommend minimizing exposure to dusts
Engineering Controls: Lab fume hood or HEPA-filtered local exhaust ventilation to capture fine particulates
Eye/Face Protection: Approved chemical splash goggles or face shield
Skin Protection: Nitrile gloves, long-sleeved lab coat, chemical apron if risk of splashing
Respiratory Protection: Approved particulate respirator (such as N95 or P100 filter) where dust is generated or in poorly ventilated environments
Hygiene Measures: Wash hands and face before leaving laboratory, launder protective clothing separately, do not reuse contaminated gloves
Appearance: Yellow to orange crystalline powder
Odor: Slight, ammonia-like or sharp chemical scent
Odor Threshold: Not specifically determined
pH: No data for aqueous solutions; typically neutral to slightly acidic
Melting Point/Freezing Point: 217-220°C
Boiling Point/Range: Stable at normal pressure; decomposition may occur before boiling
Flash Point: Not determined; assumed combustible at high temperature
Evaporation Rate: Not volatile under ambient conditions
Flammability: Can generate combustible dust; solid does not burn easily
Vapor Pressure: Negligible at room temperature
Vapor Density: Not applicable
Relative Density: 1.65–1.7 g/cm³ (estimated)
Solubility: Slightly soluble in water and alcohol, more soluble in DMSO, DMF
Partition Coefficient (n-octanol/water): Not available
Autoignition Temperature: Not available, but should be kept away from hot surfaces
Decomposition Temperature: Above 220°C
Viscosity: Not applicable (solid)
Chemical Stability: Generally stable at room temperature in dry, well-sealed containers
Reactivity: May react with strong oxidizing and reducing agents, risk of explosive decompositions with heavy contamination
Conditions to Avoid: Extreme heat, sources of ignition, direct sunlight, moisture; avoid mechanical shock to minimize dusting
Incompatible Materials: Acids, alkalis, strong oxidizers, certain metals
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, carbon monoxide, possible ammonia fumes
Polymerization: No dangerous polymerization expected during normal handling
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: LD50 (oral, rat): range 450–670 mg/kg as cited by toxicity databases
Skin Corrosion/Irritation: Causes mild to moderate skin irritation on contact
Serious Eye Damage/Irritation: Irritates eyes, may cause redness, tears, blurred vision
Respiratory/Skin Sensitization: Some evidence for sensitization following repeated exposure
Chronic Effects: Prolonged or repeated exposure linked to liver or kidney dysfunction, possible anemia or CNS depression
Carcinogenicity: Not classified by IARC, NTP, OSHA; limited or inconclusive human data
Reproductive Toxicity: Animal studies suggest possible reproductive/developmental toxicity at high doses
Mutagenicity: Evidence for genetic toxicity in some in vitro assays
Symptoms: Dizziness, skin or eye redness, gastrointestinal pain, headache, weakness, mild CNS effects
Aquatic Toxicity: Harmful to aquatic organisms based on related thiazole and nitro-compound data
Persistence and Degradability: Not readily biodegradable, potentially persistent in soil and water environments
Bioaccumulation: Has potential to bioaccumulate in aquatic species, based on structure and related compounds
Soil Mobility: Low to moderate, likely to adsorb to soil particles but may leach under acidic conditions
Other Adverse Effects: Nitro aromatic and thiazole compounds may inhibit natural microbial activity and disrupt aquatic ecosystems if released in large quantities
Environmental Precautions: Avoid direct discharge to natural waters, drains, or sewers; report accidental releases to environmental authorities as required by national or local regulations
Waste Management: Dispose as hazardous chemical waste at approved incineration or chemical treatment facility
Container Disposal: Triple rinse containers before disposal, puncture to prevent re-use, manage as hazardous waste
Recycling/Reuse: Not recommended due to toxicity
Special Precautions: Do not discharge to environment, avoid landfill or sewer disposal
Regulations: Consult local and national environmental protection agency for current rules regarding disposal of nitro-aromatic compounds and thiazole derivatives
UN Number: Unclassified under most regulations, but may be shipped as hazardous material depending on quantity and country
Proper Shipping Name: 5-Nitrothiazol-2-Ylamine or Laboratory Chemicals, N.O.S.
Transport Hazard Class: Not regulated for road/rail/sea by UN model, but check air restrictions
Packing Group: Not assigned
Transport Labels: Use “Harmful” or “Irritant” if required, mark as toxic solid for laboratory shipments
Sea (IMDG Code): Refer to carrier guidance
Air (IATA/ICAO): Review individual airline regulations; some restrict nitro-group chemicals altogether
Environmental Hazards: Not listed as marine pollutant, but protect from spillage during transport
Special Precautions: Ship in well-sealed, secondary containment; provide SDS with shipment
TSCA Status: Listed in TSCA chemical inventory
EU REACH: Not registered for large scale industrial use; restricted for certain uses
OSHA Status: Considered hazardous by criteria of Hazard Communication Standard
SARA Title III: Not subject to reporting under Section 313
DSL/NDSL: Not on Canadian DSL, import requires risk assessment
California Proposition 65: Not specifically listed
WHMIS: Regulated as toxic substance, restricted workplace exposure
Other National Inventories: Information available via supplier; common in research laboratories under permit
Labeling: Comply with local hazard communication and workplace labeling standards; always use pictograms and clear warning statements
Restrictions: Use limited to research or industrial, ban on pharmaceuticals and food use in many jurisdictions
