Product Name: 5-Ethenyl-2-Pyrrolidinone
Synonyms: N-Vinylpyrrolidone
CAS Number: 88-12-0
Molecular Formula: C6H9NO
Molecular Weight: 111.14 g/mol
Product Use: Intermediate in chemical synthesis, polymer manufacturing, adhesive production, pharmaceutical formulations, laboratory reagent
Supplier Information: Listed on the chemical label or accompanying documents; typical distributors supply chemicals to industrial and research sectors
Emergency Telephone: Refer to supplier’s published hotline for chemical emergencies
GHS Classification: Flammable liquid (Category 3), Skin irritation (Category 2), Serious eye irritation (Category 2A), Specific target organ toxicity – single exposure (Category 3)
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor; causes skin irritation; causes serious eye irritation; may cause respiratory irritation and narcotic effects
Precautionary Statements: Keep away from heat, sparks, open flames; avoid breathing mist, vapor, or spray; wash hands thoroughly after handling; wear protective gloves and eye protection
Pictograms: Flame, Exclamation mark
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Symptoms: Redness, itching, burning sensation, headache, dizziness, nausea
Substance: 5-Ethenyl-2-Pyrrolidinone
Common Name: N-Vinylpyrrolidone
Concentration: Greater than 99% (pure substance)
Impurities/Additives: Trace monomers and stabilizers may occur in commercial grades; see supplier for detailed breakdown
EC Number: 201-800-4
Index Number: 613-052-00-8
Inhalation: Move affected person to fresh air; keep at rest in a position comfortable for breathing; seek medical advice if symptoms persist
Skin Contact: Remove contaminated clothing; rinse skin with plenty of water for at least 15 minutes; seek medical attention if irritation continues
Eye Contact: Rinse cautiously with water for several minutes, removing contact lenses if present and easy to do; continue rinsing and get medical attention
Ingestion: Rinse mouth thoroughly; do not induce vomiting; seek medical advice immediately
Most Important Symptoms/Effects: Redness, swelling, pain, possible delayed-onset skin or eye injury, respiratory symptoms with high exposures
Notes to Physician: Treat symptomatically, pay attention to respiratory and CNS effects; no specific antidote known
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, alcohol-resistant foam, water spray
Unsuitable Extinguishing Media: Direct water jet as it may spread material
Specific Hazards: Vapors may form explosive mixtures with air; combustion yields toxic gases including nitrogen oxides, carbon monoxide, and carbon dioxide
Protective Equipment for Firefighters: Full protective gear, self-contained breathing apparatus
Precautions: Containers exposed to fire should be cooled with water spray; prevent runoff from entering drains or waterways
Personal Precautions: Evacuate area, ventilate, eliminate ignition sources, avoid inhalation of vapors or contact with skin/eyes
Environmental Precautions: Prevent product from entering drains, surface waters, or soil; notify responsible authorities if large spillage occurs
Methods for Cleaning Up: Contain and absorb with inert material (sand, earth, vermiculite), place in closed containers for proper disposal; wash spill site after cleanup
Decontamination: Use detergent and water; do not use solvent for removal
Special Instructions: Wear suitable protection (gloves, goggles, respirator or mask)
Safe Handling: Handle only in well-ventilated areas; keep away from heat, hot surfaces, sparks, open flames; do not breathe vapors; avoid contact with skin and eyes; ground and bond containers when transferring
Hygiene Measures: Wash thoroughly after handling; remove contaminated clothing or protective equipment before entering eating areas
Storage: Store in tightly closed containers in a cool, dry, well-ventilated place; segregate from incompatible substances such as oxidizers and acids; protect from moisture, sunlight, and static discharge
Storage Conditions: Keep away from food, drink, and animal feed; store below 25°C if possible to slow polymerization
OEL/PEL: No established occupational exposure limit; ACGIH, OSHA, and similar organizations have not set a value; use engineering controls to keep exposure as low as possible
Engineering Controls: Local exhaust ventilation, process enclosure, safety shower and eyewash station in work area
Personal Protective Equipment:
- Respiratory: Use NIOSH-approved half-mask or full-face respirator in poorly ventilated areas
- Eyes: Chemical safety goggles or face shield
- Hands: Impervious gloves (nitrile, neoprene, butyl rubber)
- Body: Lab coat or chemical-resistant apron
Environmental Controls: Prevent release to environment; use secondary containment if necessary
Appearance: Colorless to pale yellow liquid
Odor: Mild, amine like or slightly musty
Odor Threshold: Not determined
pH: 7 (as 50 g/L solution)
Melting Point/Freezing Point: -24°C
Boiling Point/Range: 95-97°C
Flash Point: 90°C (closed cup)
Evaporation Rate: Not determined
Flammability: Flammable liquid
Explosion Limits: Lower: 1.5% (v/v); Upper: not determined
Vapor Pressure: 0.45 mmHg at 25°C
Vapor Density: 3.8 (air = 1)
Relative Density: 1.03 (water = 1)
Solubility in Water: Miscible
Partition Coefficient (log Pow): -0.37
Auto-ignition Temperature: 315°C
Decomposition Temperature: Not determined
Viscosity: 1.68 mPa·s at 25°C
Chemical Stability: Stable under normal handling and storage conditions; may polymerize without inhibitor
Reactivity: Reacts with strong oxidizers, acids, and free radical initiators
Incompatible Materials: Strong oxidizers, acids, peroxides
Conditions to Avoid: Exposure to heat, sunlight, sources of ignition, absence of stabilizer, contamination with incompatible materials
Hazardous Decomposition Products: Toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides
Hazardous Polymerization: May occur under uncontrolled conditions or in absence of stabilizer, releasing heat
Acute Toxicity: Oral (rat) LD50: 670 mg/kg; Dermal (rabbit) LD50: >2000 mg/kg; Inhalation (rat) LC50: >3.1 mg/L (4 hours)
Skin Irritation: Causes skin irritation, possible dermatitis on repeated exposure
Eye Damage/Irritation: Serious eye irritation, risk of corneal injury
Respiratory Sensitization: Not classified as a respiratory sensitizer, can cause upper respiratory tract irritation
Skin Sensitization: Not typically expected
Chronic Effects: Prolonged or repeated exposure may result in effects on the central nervous system, liver, and kidneys
Carcinogenicity: IARC: Group 3 (not classifiable); no conclusive evidence for human carcinogenicity
Mutagenicity: Some positive results in bacterial assays, not considered mutagenic in vivo
Reproductive Toxicity: No evidence of adverse reproductive effects in animal studies
Symptoms of Overexposure: Central nervous system depression, headache, dizziness, nausea, irritation to eyes, skin, and respiratory tract
Toxicity to Aquatic Life: Fish (LC50, 96h): 68 mg/L (Lepomis macrochirus); Daphnia (EC50, 48h): 47 mg/L
Persistence and Degradability: Readily biodegradable; significant removal in biological wastewater treatment processes
Bioaccumulation: Low potential; log Kow indicates low likelihood of bioconcentration
Mobility in Soil: High mobility due to complete water miscibility
PBT/vPvB Assessment: Does not meet criteria for persistent, bioaccumulative, or toxic classification
Other Adverse Effects: May cause local depletion of dissolved oxygen in aquatic systems via rapid degradation
Waste Treatment Methods: Dispose of contents/container in accordance with local, regional, national, and international regulations
Waste Disposal Recommendations: Incineration preferred; chemical must not be disposed of with household waste or poured into drains
Contaminated Packaging: Empty containers should be decontaminated and disposed of as hazardous waste
Safe Handling of Waste: Wear appropriate physical and chemical protection; keep waste separate from incompatible substances; follow proper labeling and documentation
UN Number: UN 2810
UN Proper Shipping Name: Toxic liquid, organic, n.o.s. (contains 5-Ethenyl-2-Pyrrolidinone)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Environmental Hazards: Not regulated as marine pollutant
Special Precautions for User: Avoid release to the environment; proper labeling and segregation in accordance with applicable regulations
Transport in Bulk: Not listed under MARPOL; consult IMO or supplier for further requirements
DOT, IATA, IMDG Regulations: All may have specific packaging and containment protocols; check with carrier
TSCA Inventory: Listed
EINECS/ELINCS: Listed (201-800-4)
DSL/NDSL (Canada): Listed
AICS (Australia): Listed
REACH Status (EU): Registered
OSHA Hazard Communication: Classified as hazardous; all applicable hazard statements and precautions must appear on labels and SDS
SARA Title III Sections 302/313: Not listed as an extremely hazardous or reportable substance
California Proposition 65: Not listed as a known carcinogen or reproductive toxin
Other Regional Regulatory Listings: Consult country-specific regulations for additional requirements
