Product Name: 5-Chlorothiophene-2-Sulfonyl Chloride
Chemical Formula: C4H2ClO2S2
Synonyms: 2-Sulfonyl chloride-5-chlorothiophene, 5-Chlorothiophene-2-sulphonyl chloride
Recommended Use: Intermediate for chemical synthesis, pharmaceuticals, agrochemicals
Manufacturer: Provide details including business address, contact phone number, and emergency call center
CAS Number: 78633-19-7
Emergency Contact: 24-hour hotline, seek immediate attention for accidental exposure
Restriction on Use: Special handling for laboratory research, professional and industrial applications
Signal Word: Danger
GHS Classification: Acute Toxicity Category 3 (oral, dermal, inhalation), Skin Corrosion/Irritation Category 1B, Serious Eye Damage/Irritation Category 1, Specific Target Organ Toxicity Single Exposure Category 3
Hazard Pictograms: Skull and crossbones, Corrosive symbol, Exclamation mark
Hazard Statements: Causes severe skin burns and eye damage. Fatal if inhaled. Toxic if swallowed or in contact with skin. May cause respiratory irritation.
Precautionary Statements: Avoid breathing dust or vapors. Wear protective gloves, clothing, and eye protection. Handle contents only in a chemical fume hood. Keep away from water and moisture because violent hydrolysis releases hazardous gases. Seek medical advice if symptoms occur.
Other Hazards: Decomposes in contact with water to liberate hydrogen chloride and sulfur oxides.
Chemical Name: 5-Chlorothiophene-2-Sulfonyl Chloride
Purity: ≥98% (per supplier specifications)
Impurities: Trace amounts of related thiophene derivatives, residual starting materials may be present below 1% total weight
CAS Number: 78633-19-7
EC Number: 616-578-3
Molecular Weight: 196.65 g/mol
Eye Contact: Flush immediately for at least 15 minutes with plenty of water, lifting upper and lower eyelids. Remove contact lenses if present and easy to do. Seek urgent medical treatment.
Skin Contact: Immediately remove contaminated clothing and wash skin thoroughly with soap and water for at least 15 minutes. Obtain prompt medical attention.
Inhalation: Remove to fresh air, keep patient still and warm. If respiratory distress occurs, provide oxygen or artificial respiration. Call poison control center or physician urgently.
Ingestion: Rinse mouth. Do not induce vomiting. Never give anything by mouth if victim is unconscious or convulsing. Seek immediate emergency medical help.
Notes for Physician: Symptomatic and supportive treatment. Consider delayed pulmonary edema or corrosive injury.
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, or water spray in fog form. Avoid direct water stream unless absolutely necessary.
Hazards from Combustion: Releases toxic fumes of hydrogen chloride, sulfur oxides, and chlorinated compounds on burning.
Special Equipment: Full protective gear, self-contained breathing apparatus (SCBA), complete chemical protective suit.
Advice: Remove containers from fire zone if possible. Dike runoff water for proper disposal. Evacuate personnel if necessary.
Personal Precautions: Evacuate area, ventilate, prevent exposure to vapors. Use chemical-resistant gloves, full-face respiratory protection, chemical splash goggles, and suitable protective clothing.
Environmental Precautions: Prevent spill from entering drains, watercourses, or soil. Dike or contain runoff with inert material like dry sand.
Clean Up Methods: Absorb with inert dry material (sand, vermiculite), collect in tightly sealed containers for hazardous waste disposal. Wash area with copious amounts of water after material has been properly removed.
Disposal: Dispose of residue in accordance with local regulations; contact licensed hazardous waste handler.
Handling: Work only in well-ventilated area, preferably inside a chemical fume hood. Avoid any contact with eyes, skin, or clothing. Avoid inhaling vapors or dust. Remove contaminated clothing and wash before reuse. Do not eat, drink, or smoke during use.
Storage: Keep container tightly closed in a dry, well-ventilated, cool area (preferably below 25°C). Store away from water, bases, alcohols, reducing agents, and incompatible materials. Use corrosion-resistant secondary containment. Monitor for any signs of container degradation or leaks.
Engineering Controls: Use chemical fume hood, proper ventilation, and closed systems. Maintain eyewash stations and emergency showers in the immediate work area.
Respiratory Protection: Wear approved full-face respirator with acid gas/cartridge filter, especially if ventilation cannot control vapor exposure.
Skin Protection: Wear chemical-resistant gloves (e.g., nitrile), lab coat, apron, and long sleeves.
Eye Protection: Tight-fitting chemical splash goggles, face shield during handling.
Hygiene Measures: Wash thoroughly before breaks, after handling, and at end of shift. Do not touch face or other exposed skin without washing.
Exposure Limits: No established occupational exposure limits for this compound; treat as highly toxic and corrosive.
Appearance: Off-white to light yellow crystalline solid or powder
Odor: Pungent, acrid, possibly irritating
Melting Point: 54–57°C
Boiling Point: Not available; decomposes before boiling
Solubility: Hydrolyzes rapidly in water with heat and fume evolution
Density: 1.7–1.9 g/cm³
pH: Not applicable (reacts with water)
Vapor Pressure: Not determined
Partition Coefficient (log Pow): Not established
Flash Point: Not applicable (non-combustible, decomposes)
Other Data: Emits corrosive vapors on contact with air or moisture
Chemical Stability: Stable under recommended storage conditions in a sealed container, away from light, moisture, and extreme temperatures.
Incompatible Materials: Water, alcohols, amines, bases, oxidizing and reducing agents. May react violently producing toxic gases.
Hazardous Decomposition: Hydrogen chloride, sulfur dioxide, sulfur trioxide, and corrosive chlorinated fumes form during fire or upon hydrolysis.
Polymerization: Not known to occur.
Acute Toxicity: Oral and inhalation exposure can result in serious toxicity or death. Corrosive to gastrointestinal tract and respiratory mucosa.
Skin and Eye Irritation: Severe burns to skin and eyes on contact. Irreversible eye effects possible.
Inhalation Effects: Severe irritation, coughing, lung edema, difficulty breathing. High risk of delayed pulmonary effects.
Chronic Effects: Repeated exposure may cause dermatitis, decreases in respiratory function, or delayed organ damage.
Target Organs: Respiratory tract, eyes, skin.
Mutagenicity/Carcinogenicity: No specific studies available; handle with caution due to chemical reactivity and class.
Sensitization: Not classified but potential exists based on structure.
Ecotoxicity: Toxic to aquatic life due to rapid hydrolysis releasing acids and sulfur compounds. Avoid release to environment.
Persistence and Degradability: Reacts quickly with water, not persistent under environmental conditions.
Bioaccumulation Potential: Low due to high reactivity and breakdown in water.
Mobility in Soil: Will hydrolyze on contact with moisture; unlikely to migrate in environment.
Other Hazards: Harmful to aquatic organisms by acidification of water systems. Do not dispose into drains or natural waterways.
Waste Disposal: Collect residue into a clearly-labeled, leakproof container intended for hazardous materials. Consult local, regional, and national waste regulations for incineration or chemical treatment. Do not release to environment.
Contaminated Packaging: Decontaminate packaging thoroughly or send for approved hazardous waste disposal.
Special Precautions: Neutralize with dilute alkaline solution only under controlled conditions in a suitable fume hood.
Disposal Contact: Use authorized hazardous waste contractor; maintain records of waste disposal as regulated by local rules.
UN Number: UN 3261
Proper Shipping Name: Corrosive solid, acidic, organic, n.o.s. (5-Chlorothiophene-2-Sulfonyl Chloride)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: II (medium danger)
Labels Required: Corrosive hazard label
Marine Pollutant: No, but prevent spillage into waterways
Special Precautions: Only trained personnel should handle shipments. Protect containers from physical damage and keep upright and sealed. Detailed documentation required for international and regional transport.
Regulatory Status: Subject to chemical safety regulations under OSHA in the US, REACH registration in the EU, and similar international rules.
Hazard Codes: C (Corrosive); T (Toxic); Xi (Irritant)
SARA Title III: Not listed as an extremely hazardous substance; treat as hazardous under workplace hazard communication.
California Proposition 65: Not listed, but handle with similar caution.
Workplace Classification: Ensure full training for all chemical handlers and detailed reporting of any adverse incidents.
Inventory Status: Present on EINECS/ELINCS, TSCA, and other major inventories.
Pictograms and Signal Words: Check packaging and ensure up-to-date logistic markings for emergency response.
