Product Name: 5-Chloro-2-(Trifluoromethyl)-Pyrazine
Synonyms: 5-Chloro-2-trifluoromethylpyrazine
Chemical Formula: C5H2ClF3N2
Molecular Weight: 184.54 g/mol
CAS Number: 875781-05-2
Recommended Use: Intermediate for organic synthesis, agrochemical research
Supplier Contact: Safety and regulatory compliance division
Emergency Contact: Regional chemical hazard center
Classification: Flammable liquid, skin irritant, eye irritant, suspected of damaging fertility, hazardous to aquatic life
Label Elements: Pictogram: Exclamation mark, Environment, Health hazard
Signal Word: Warning
Hazard Statements: Combustible, may cause skin and eye irritation, toxic if inhaled or ingested, suspected reproductive toxin, may cause damage to organs through prolonged exposure, toxic to aquatic organisms causing possible long-term effects in water bodies
Precautionary Statements: Avoid inhalation, wear protective gear, prevent release into the environment, keep away from heat sources
Chemical Name: 5-Chloro-2-(Trifluoromethyl)-Pyrazine
Concentration: >98% by weight
Impurities: Trace amounts of related pyrazine compounds, organic solvents (residual)
Stabilizers/Additives: None reported
Inhalation: Move the person into fresh air, provide oxygen if breathing is difficult, seek medical attention
Skin Contact: Remove contaminated clothing, wash area with plenty of soap and water for at least fifteen minutes, consult a doctor if irritation persists
Eye Contact: Rinse immediately with clean water for fifteen minutes, remove contact lenses if possible, seek immediate medical attention
Ingestion: Rinse mouth with water, never give anything by mouth to an unconscious person, get medical assistance immediately
General: Call poison control if exposure occurs, monitor for respiratory distress
Suitable Extinguishing Media: CO2, dry chemical, foam, do not use direct water jet
Specific Hazards: Toxic gases such as hydrogen chloride, nitrogen oxides, and carbonyl fluoride may form during combustion
Special Protective Equipment: Wear self-contained breathing apparatus and chemical-resistant protective clothing
Firefighting Instructions: Evacuate surrounding area, use water spray to cool containers, avoid inhaling fumes
Explosion Data: Vapors may form explosive mixture with air above flash point
Personal Precautions: Wear gloves, goggles, and laboratory coat to avoid contact
Environmental Precautions: Prevent spillage from entering drains, surface, and ground water
Cleanup Methods: Absorb with inert material (sand, vermiculite), collect into appropriate waste container, ventilate area, wash spill site after material collection
Disposal: Follow procedures listed under disposal considerations
Handling: Avoid inhaling dust, vapor, or mist, handle within a chemical fume hood, use appropriate personal protective equipment, no eating or drinking around the workspace, handle containers with care to prevent spills
Storage: Store tightly closed in original container, in a dry, cool, well-ventilated location, away from incompatible substances (strong oxidizers, base or acid), keep away from direct sunlight and ignition sources
Engineering Controls: Local exhaust ventilation, regular air monitoring, closed systems for large-volume work
Personal Protective Equipment: Safety goggles, chemical-resistant gloves, suitable laboratory coat, if needed for operations generating vapor or dust use NIOSH-approved respirator
Hygiene Measures: Wash hands thoroughly after handling, do not eat or drink before washing off residue
Appearance: Off-white to pale yellow crystalline powder
Odor: Faint, characteristic odor
Odor Threshold: Not determined
pH: Not available
Melting Point: 56–59°C
Boiling Point: 172–174°C at 760 mmHg
Flash Point: 65°C
Evaporation Rate: Not determined
Flammability: Combustible
Vapor Pressure: 0.6 mmHg at 25°C
Vapor Density: Not available
Relative Density: 1.44 g/cm³
Solubility: Sparingly soluble in water, soluble in polar organic solvents (acetonitrile, ethanol)
Partition Coefficient (log Kow): 2.95 (estimated)
Chemical Stability: Stable under recommended storage conditions
Conditions to Avoid: Strong heat, sunlight, open flames, incompatible chemicals
Incompatible Materials: Oxidizing agents, acids, bases
Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon oxides, fluorinated compounds
Hazardous Polymerization: Not known under normal conditions
Acute Toxicity: Low to moderate toxicity via oral, dermal, or inhalation exposure (exact LD50 not established)
Skin Corrosion/Irritation: May cause irritation with redness, itching
Eye Damage/Irritation: Can cause serious irritation or damage with prolonged contact
Respiratory Sensitization: Potential for upper respiratory tract irritation
Germ Cell Mutagenicity: No reliable data available
Carcinogenicity: Not listed as carcinogen by IARC, NTP, OSHA
Reproductive Toxicity: Suspected of harming fertility or unborn child
Repeated Dose Toxicity: Long-term contact may affect liver and kidney function
Symptoms of Exposure: Headache, dizziness, nausea if inhaled; skin or eye redness on contact
Ecotoxicity: Harmful to aquatic life, risk of bioaccumulation in aquatic organisms
Persistence and Degradability: Not readily biodegradable in soil or water, may persist for long periods
Bioaccumulative Potential: Potential due to log Kow above 2
Mobility in Soil: Partial adsorption, mobility may vary with soil type
Other Adverse Effects: Release into the environment may cause toxic effects in aquatic and terrestrial habitats
Waste Disposal Methods: Disposal according to local, regional, and national regulations, incineration in approved facility is recommended
Contaminated Packaging: Treat empty containers as hazardous material, avoid reuse, follow label instructions for safe disposal
Regulatory Requirements: Proper identification for hazardous waste shipping, documentation for traceability
UN Number: UN 2810
UN Proper Shipping Name: Toxic liquid, organic, n.o.s. (contains 5-Chloro-2-(Trifluoromethyl)-Pyrazine)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Marine Pollutant: Yes
Transport Labels: Toxic, Marine Pollutant
Special Precautions for User: Ensure secure containers, follow emergency response regulations during shipment
Additional Information: Comply with ICAO/IATA, IMO/IMDG, and DOT requirements for hazardous goods
US Federal Regulations: TSCA listed, SARA 313 not listed
EU Regulations: Classified under Regulation (EC) No 1272/2008 (CLP), REACH registered where applicable
Canada WHMIS Classification: D2B (Toxic materials causing other toxic effects)
Other Country Regulations: Subject to chemical registration and inventory reporting in China, Japan, Australia, South Korea
Labeling: Must carry hazard and precautionary statements as required for transport and use
