Product Name: 5-Chloro-1-Methyl-4-Nitroimidazole
Chemical Formula: C4H4ClN3O2
Synonyms: 1-Methyl-5-chloro-4-nitroimidazole
CAS Number: 13301-47-2
Recommended Use: Research, chemical synthesis, pharmaceutical intermediate
Supplier Information: Details according to the manufacturer label
Emergency Phone: National Poison Center or supplier emergency number
GHS Classification: Acute Toxicity (Oral) Category 4, Eye Irritation Category 2A, Skin Irritation Category 2
Signal Word: Warning
Hazard Statements: Harmful if swallowed. Causes serious eye irritation. Causes skin irritation.
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust or vapors. Wear protective gloves, eye protection, and suitable clothing. Wash hands thoroughly after handling.
Potential Health Effects: Inhalation may cause respiratory irritation and headache. Skin or eye contact likely to trigger redness, itching, and potential swelling. Ingestion can lead to nausea, vomiting, and possible harm to internal organs.
Chemical Name: 5-Chloro-1-Methyl-4-Nitroimidazole
Concentration: ≥98% by weight
Chemical Abstracts Service (CAS) Number: 13301-47-2
Impurities/Additives: Impurities below 2% total, including related imidazoles and inorganic residues
Ingredient Disclosure: No known additives or proprietary blends, single component substance
Eye Contact: Rinse cautiously with water for 15 minutes, keeping eyelids open. Remove contact lenses if present and easy. Seek medical attention.
Skin Contact: Wash skin with soap and water for several minutes. Remove contaminated clothing. Obtain medical advice if irritation persists.
Inhalation: Move individual to fresh air. Allow to rest in a well-ventilated area. Call for medical help if symptoms develop (coughing, shortness of breath).
Ingestion: Rinse mouth, give water to drink if person is conscious. Do not induce vomiting. Seek immediate medical support.
Most Important Symptoms: May include eye or skin irritation, respiratory discomfort, gastrointestinal distress.
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, or carbon dioxide
Specific Hazards: Thermal decomposition can generate toxic gases such as hydrogen chloride, nitrous oxides, carbon monoxide.
Protective Equipment: Firefighters should wear self-contained breathing apparatus, gloves, and protective clothing.
Special Procedures: Cool exposed containers with water spray if possible. Avoid water runoff contamination.
Combustion Products: Chlorinated and nitrogenous fumes possible under intense heat.
Personal Precautions: Prevent skin and eye contact, avoid inhaling dust. Use personal protective equipment—safety goggles, gloves, respirator if needed.
Environmental Precautions: Do not allow material to enter drains, surface water, or soil. Contain spilled product with inert absorbent.
Cleanup Methods: Sweep up and collect in a suitable labeled container for disposal. Ventilate the area thoroughly during work.
Follow-Up: Wash contaminated surface with water and detergent after removal is complete.
Waste Disposal: Dispose of cleanup residue according to local regulations.
Safe Handling: Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep containers tightly sealed.
Technical Measures: Use only in well-ventilated areas with local exhaust. Employ antistatic equipment in case of dust risk.
Storage Conditions: Store at room temperature away from direct sunlight and sources of ignition. Keep in original container in a cool, dry, well-ventilated area. Segregate from incompatible materials such as strong acids, bases, oxidants.
Packaging Materials: Store in tightly sealed glass or properly lined metal containers.
Exposure Limits: No specific occupational exposure limits published.
Engineering Controls: Work in fume hood or area with adequate extraction. Install eyewash stations and safety showers nearby.
Personal Protection: Wear chemical-resistant gloves (nitrile recommended), safety glasses with side shields or goggles, and protective lab coat.
Respiratory Protection: Use a dust mask or respirator (N95/P3) when dust or aerosols might release.
Hygiene Measures: Wash hands, forearms, and face thoroughly after handling. Remove contaminated clothing before entering eating areas.
Environmental Controls: Prevent discharge into environment from laboratory or industrial areas.
Appearance: Pale yellow to brownish fine crystalline powder
Odor: Odorless or faint chemical scent
Molecular Weight: 177.55 g/mol
pH: Not applicable (solid at room temperature)
Melting Point: Typically between 169–173°C
Boiling Point: Data not available, substance decomposes before boiling
Solubility: Slightly soluble in water; soluble in DMSO, methanol, ethanol
Vapor Pressure: Negligible at 20°C
Partition Coefficient (Log Pow): Data not available
Other Data: No explosive properties identified. Not flammable under normal conditions.
Chemical Stability: Stable under standard conditions if kept dry and in closed container.
Reactivity: Incompatible with strong oxidizers, strong bases, reducing agents.
Hazardous Reactions: No hazardous polymerization or violent decomposition anticipated in storage.
Decomposition Products: Heating releases gases including hydrogen chloride and nitrogen oxides.
Storage Recommendations: Protect from moisture, sunlight, and high heat to sustain stability.
Acute Toxicity: Oral LD50 (rat) estimated between 300–2000 mg/kg
Skin Corrosion/Irritation: Likely to cause irritation with prolonged contact
Serious Eye Damage/Irritation: Causes eye irritation
Respiratory Sensitization: Potential to produce mild respiratory irritation from dust
Germ Cell Mutagenicity: Not listed as mutagenic based on available data
Carcinogenicity: Not classified as carcinogenic by IARC or ACGIH
Reproductive Toxicity: No information indicating reproductive effects
Chronic Effects: No chronic health effects documented in publicly available sources
Aquatic Toxicity: Limited data; structurally related substances show moderate toxicity to aquatic life
Persistence and Degradability: Likely persistent due to nitro- and chloro-functional groups; not readily biodegradable
Bioaccumulation: Evidence from similar compounds suggests moderate bioaccumulation risk
Mobility in Soil: Low to moderate, may leach under certain soil conditions
Other Adverse Effects: Avoid uncontrolled release into waterways to minimize environmental load.
Waste Treatment Methods: Dispose of content and container according to approved waste handlers
Contaminated Packaging: Triple rinse container; puncture and discard via hazardous waste program
Disposal Precautions: Incinerate in approved facility or land disposal as hazardous waste based on local regulations
Additional Information: Do not flush into sewer, surface water, or groundwater. Ensure compliance with national and local environmental laws.
UN Number: Not classified under UN dangerous goods codes
Proper Shipping Name: Not regulated for transport under international and domestic laws
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Marine Pollutant: Not listed as marine pollutant
Special Precautions: Protect containers during transport, secure to prevent movement and accidental release.
International Inventory Status: Not listed under TSCA (USA), REACH (Europe), DSL (Canada), or other major inventories as a commercial chemical
Labeling: Compliant with GHS hazard warning and pictogram requirements
Other Sector-Specific Requirements: Laboratory use may trigger local occupational health, chemical hygiene, and reporting mandates
Restrictions: Check importation laws and workplace chemical safety laws for site-specific restrictions
Additional Notes: Users must keep up-to-date with changing chemical control regulations in relevant jurisdictions
