Product Name: 5-Chloro-1-Methyl-1H-Imidazole
Chemical Formula: C4H5ClN2
Other Names: 5-Chloro-N-methylimidazole, 1-Methyl-5-chloroimidazole
CAS Number: 15114-97-9
Recommended Uses: Organic synthesis, laboratory reagent, pharmaceutical intermediate
Supplier Details: Manufacturer or distributor’s name, address, phone number
Emergency Contact: Chemtrec or local emergency service number
GHS Classification: Irritant, Acute Toxicity Category 4 (oral), Skin Irritation Category 2, Eye Irritation Category 2A
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin irritation, causes serious eye irritation
Precautionary Statements: Avoid contact with skin and eyes, avoid breathing dust or vapor, wash hands thoroughly after handling, wear protective gloves, eye protection, and appropriate lab clothing
Pictograms: Exclamation mark symbol
Potential Health Effects: Short-term exposure brings in irritation of respiratory tract, eyes, and skin. Longer exposure triggers headaches, nausea, possible central nervous system effects.
Chemical Name: 5-Chloro-1-Methyl-1H-Imidazole
Chemical Formula: C4H5ClN2
Purity: Greater than 97%
Impurities: Trace starting materials or solvents from manufacture, no known additional hazardous components above 1% concentration
Formula Weight: 116.55 g/mol
Inhalation: Move person to fresh air right away, keep at rest in a comfortable position, get medical attention if symptoms show up such as coughing, dizziness, or shortness of breath
Skin Contact: Take off contaminated clothing, flush skin thoroughly with water for at least 15 minutes, seek medical attention if irritation continues
Eye Contact: Rinse out eyes with plenty of water for a minimum of 15 minutes, keep eyelids open and apart, remove contact lenses if present before rinsing, get medical help urgently
Ingestion: Rinse out mouth, do not force vomiting, never provide anything by mouth to someone unconscious, seek immediate medical advice
Symptoms: Redness, pain, itching, eye watering, nausea, headache, unconsciousness in severe cases
Suitable Extinguishing Media: Use dry chemical, carbon dioxide, foam, or water spray; never use solid water streams directly on chemical fires
Unusual Fire Hazards: Fumes may contain toxic or corrosive gases such as hydrogen chloride, nitrogen oxides, and carbon oxides
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear; stay upwind
Special Procedures: Evacuate all nonessential personnel, cool containers exposed to flames with water spray, prevent runoff from entering drains
Hazardous Combustion Products: Chlorine, nitrogen oxides, carbon monoxide, and other irritating or toxic gases
Personal Precautions: Put on protective gloves, goggles, and lab coat, ventilate the affected area, avoid dust formation and inhalation
Environmental Precautions: Prevent spillage from reaching waterways and soil, contain material using inert absorbents or spill pads, avoid release into sewers
Cleanup Methods: Scoop up and transfer solid residues to a suitable chemical waste container, decontaminate spill area with soap and water, label and dispose of all cleanup materials as hazardous chemical waste
Emergency Response: Notify designated safety personnel, evacuate unnecessary staff, wear appropriate respiratory protection in closed or poorly ventilated spaces
Safe Handling: Use in chemical fume hoods or well-ventilated areas, keep containers tightly shut, use non-sparking tools to minimize dust buildup, never eat or smoke while handling chemicals
Storage Conditions: Store in original labeled containers away from incompatible materials such as oxidizers or strong acids, keep away from direct sunlight or heat, maintain storage below 25°C in a dry, cool area
Incompatible Materials: Strong acids, alkalis, oxidizing agents, avoid contact with moisture that could cause hydrolysis or decomposition
Packaging Material: Use chemical-resistant glass or high-density polyethylene containers with tight-fitting caps
Storage Precautions: Label containers with chemical name and hazard class, secure the storage location, restrict access to trained individuals only
Exposure Limits: No established OSHA, ACGIH, or NIOSH exposure limits for this compound, follow workplace good practices to keep air concentrations as low as possible
Engineering Controls: Work in fume hoods with forced ventilation, use local exhaust if available, avoid open handling of powders
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), safety goggles or wrap-around glasses, lab coat with long sleeves, closed-toe shoes, face shield if significant risk of splashing or dust generation, respiratory protection such as NIOSH-approved half mask if airborne exposure likely
Hygiene Measures: Wash thoroughly after handling, clean personal protective equipment, keep food and drink away from chemical storage and work areas
Appearance: White to light beige crystalline powder
Odor: Possible faint, unusual organic odor
Melting Point: Between 84°C and 89°C
Boiling Point: Decomposes before boiling
Solubility: Low to moderate solubility in water, soluble in most organic solvents such as ethanol, methanol, and acetone
pH: Not applicable (neutral in most solutions)
Vapor Pressure: Negligible at 20°C
Density: 1.22 g/cm³ (approximate)
Partition Coefficient (log Pow): Estimated 0.4–0.8
Evaporation Rate: Not volatile under typical conditions
Flash Point: Not determined, likely above ambient
Chemical Stability: Stable under recommended storage and handling conditions, susceptible to decomposition at high heat or exposure to strong acids/bases
Reactivity: Not self-reactive under normal conditions, sensitive to strong oxidizing agents and strong acids
Hazardous Reactions: Can liberate toxic or corrosive fumes on combustion or decomposition
Conditions to Avoid: Moisture, heat, open flame, direct sunlight, incompatible chemicals
Incompatible Materials: Oxidizing agents, acids, alkalis
Polymerization: No known hazardous polymerization
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: Oral LD50 (rat) estimated at 400–800 mg/kg body weight; data on skin and inhalation toxicity not fully established
Skin Irritation: Causes moderate skin irritation, redness, and possible burns on prolonged contact
Eye Effects: Causes moderate to severe irritation, conjunctivitis, possible corneal injury on direct exposure
Inhalation Effects: Dust or vapor may irritate nose, throat, lungs; higher concentrations bring in nausea or dizziness
Chronic Toxicity: No long-term animal or human data, not considered a carcinogen based on available information
Sensitization: No known sensitizing potential
Mutagenicity/Carcinogenicity: Not classified as mutagenic or carcinogenic, insufficient data for reproductive toxicity
Eco-Toxicity: Toxic to aquatic organisms at low concentrations due to imidazole core and chlorine atom; data suggest LC50 (fish, 96h) between 10–100 mg/L
Persistence: Will slowly break down in soil and aerobic water systems, resistant to quick biodegradation
Bioaccumulation: Low bioaccumulation potential, based on log Pow and structural analysis
Mobility: Moderate mobility in soil, soluble in water but not highly volatile
Other Environmental Hazards: Do not allow product or wastes to contaminate surface water, groundwater, or soil; runoff may be hazardous to aquatic life
Disposal Methods: Dispose through licensed waste contractor; incineration in chemical incinerator with afterburner and scrubber preferred when possible
Contaminated Packaging: Treat empty containers as hazardous, triple rinse with water or inert solvent, dispose as hazardous waste
Regulatory Requirements: Do not use domestic sewer or municipal waste streams; follow national, regional, and local environmental law and guidance
Special Precautions: Document waste disposal, keep waste containers tightly sealed, label with contents and hazards, consider compatibility of mixed wastes
UN Number: Not assigned for this chemical; consult latest transport regulations
Proper Shipping Name: 5-Chloro-1-Methyl-1H-Imidazole or laboratory chemical, n.o.s.
Hazard Class: Not classified under UN transport hazard classes
Packing Group: Not assigned
Transport Labels: Use class 6.1 (toxic) or class 9 (miscellaneous) for larger quantities, based on jurisdiction
Special Precautions for Transport: Keep container tightly closed and secured; transport in compliance with local, state, and federal regulations on hazardous chemicals; provide absorbent packing materials in case of accidental breakage
TSCA Status (US): Listed or meets criteria for exemption
REACH (EU): Registration exempted due to tonnage or application type; check current regulatory status before import or distribution in Europe
WHMIS (Canada): Classified as hazardous, consult specific workplace requirements
Other Regulations: Not listed as a carcinogen by IARC, NTP, or OSHA; not subject to special restrictions under major international conventions
SARA 313: Does not contain specific chemicals regulated by this section
California Proposition 65: Product not on list of chemicals known to cause cancer or reproductive harm
Additional Notes: Compliance with local occupational health, waste handling, and transportation regulations remains the responsibility of the user; regularly consult updates for chemical safety and regulatory status
