Product Name: (5-Bromothiophen-2-Yl)-Phenylmethanone
Chemical Formula: C11H7BrOS
CAS Number: 65223-91-4
Synonyms: 2-Benzoyl-5-bromothiophene; 5-Bromo-2-thienyl phenyl ketone
Intended Use: Laboratory research, synthesis intermediate, specialty chemical
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GHS Classification: Acute Toxicity (oral, dermal, inhalation) Category 4; Skin and Eye Irritation Category 2; Specific Target Organ Toxicity (Single Exposure) Category 3
Signal Word: Warning
Hazard Statements: Harmful if swallowed, harmful in contact with skin or if inhaled, causes serious eye irritation, may cause respiratory irritation
Precautionary Statements: Avoid breathing dust or vapors, wash hands after handling, use only outdoors or in well-ventilated area, wear protective gloves, eye and face protection
Potential Health Effects: Irritation to eyes, skin, and respiratory tract; ingestion or inhalation may result in nausea, headache, drowsiness, or other symptoms of toxicity
Environmental Hazards: Toxic to aquatic life with long lasting effects
NFPA Ratings: Health: 2, Flammability: 1, Reactivity: 0
Chemical Component: (5-Bromothiophen-2-Yl)-Phenylmethanone
Concentration: ≥ 98%
Impurities: Unreacted starting materials, process-related substances <1%
Stabilizers/Additives: None
Molecular Weight: 267.14 g/mol
Structural Formula: Benzoyl group attached to 5-bromothiophene ring
Inhalation: Remove to fresh air immediately. If difficulty in breathing persists, seek medical advice. Provide oxygen if available, keep person warm. Symptoms can include throat irritation and coughing.
Skin Contact: Remove contaminated clothing. Wash affected area thoroughly with soap and water. Contact physician if irritation develops or persists.
Eye Contact: Rinse opened eye for at least 15 minutes with plenty of water, lifting upper and lower eyelids occasionally. Get medical assistance if redness, pain, or blurred vision occur.
Ingestion: Call poison control or seek medical attention. Rinse mouth with water. Do not induce vomiting without medical advice. Watch for symptoms like nausea and dizziness.
Important Note: Show this safety data sheet to attending medic
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, water spray
Unsuitable Media: Direct water jets, as these may spread the fire
Special Hazards: May release toxic fumes such as bromine, sulfur oxides, and carbon oxides during combustion
Protective Equipment: Self-contained breathing apparatus and full fire-fighting gear recommended
Firefighting Advices: Avoid inhalation of hazardous decomposition products; isolate area and stay upwind
Explosion Risk: No known explosion hazard; treat as combustible solid
Personal Precautions: Evacuate area unless trained in spill response. Wear suitable respiratory protection, chemical-resistant gloves, goggles, and laboratory protective clothing
Environmental Precautions: Prevent product from entering drains or water sources. Notify authorities if large quantities escape into environment
Methods for Containment: Contain spill using inert materials like vermiculite or sand; do not use combustible absorbents like sawdust
Cleanup Procedures: Collect spilled material in suitable closed and labeled containers for proper disposal; ventilate affected area and decontaminate with detergent and water
Handling Precautions: Use in a well-ventilated area. Avoid breathing dust and avoid contact with skin, eyes, and clothing. Keep containers tightly closed when not in use. Use proper lifting techniques when moving containers.
Hygiene Measures: Do not eat, drink, or smoke during handling. Wash hands thoroughly after handling.
Storage Conditions: Store in a dry place, away from sources of ignition and out of direct sunlight. Keep in tightly sealed original containers at room temperature or as directed.
Incompatible Materials: Strong oxidizing agents, strong acids and bases.
Specific Requirements: Segregate from foodstuffs and incompatible chemicals, label storage area appropriately.
Exposure Limits: No established OSHA/ACGIH limits; minimize exposure as much as possible
Engineering Controls: Use fume hood or local exhaust ventilation
Personal Protective Equipment: Wear NIOSH approved respirator if dust or vapors may be generated, chemical-resistant gloves (nitrile or neoprene), lab coat, chemical safety goggles; in case of large scale handling wear face shield and protective suit
Workplace Hygiene: Remove contaminated clothing before leaving work area. Eye wash stations and safety showers should be accessible
Appearance: Off-white or pale yellow crystalline powder
Odor: Odorless or slight aromatic odor
pH: Not applicable (insoluble in water)
Melting Point: Approx. 100–105°C
Boiling Point: Data not available
Flash Point: >100°C
Flammability: Combustible solid, not classified as highly flammable
Vapor Pressure: Negligible at ambient conditions
Solubility: Insoluble in water; soluble in organic solvents like DMSO, DMF, chloroform
Density: About 1.6 g/cm³
Partition Coefficient: Log Pow >2.5 (estimated, based on structure)
Evaporation Rate: Not determined
Decomposition Temperature: Decomposes above 200°C
Chemical Stability: Stable under normal storage and handling conditions
Possible Hazardous Reactions: No dangerous reactions known under recommended conditions
Conditions to Avoid: Heating above decomposition temperature, direct sunlight, strong oxidizing environments
Incompatible Materials: Oxidizing agents, strong acids and bases may cause dangerous reactions
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, bromine compounds, sulfur oxides
Acute Toxicity: Harmful if swallowed, inhaled, or in contact with skin
LD50 (Oral, Rat): Estimated 200–2000 mg/kg
Skin Irritation: Causes moderate irritation, may result in redness and discomfort
Eye Irritation: Causes significant eye irritation including redness, watering, and pain
Respiratory Sensitization: Inhalation of dust or vapors may produce coughing, throat irritation, and shortness of breath
Chronic Effects: Prolonged or repeated exposure may cause skin dryness or cracking, persistent eye damage cannot be ruled out
Carcinogenicity: No data available on carcinogenic potential; not listed as a known carcinogen by IARC, NTP, or OSHA
Mutagenicity / Reproductive Toxicity: No studies available; minimize exposure to mitigate unknown risks
Aquatic Toxicity: Very toxic to aquatic life, especially invertebrates and fish (based on structure and related compounds)
Persistence and Degradability: Estimated to be poorly biodegradable; may persist in the environment
Bioaccumulative Potential: Expected moderate potential due to aromatic structure and bromine content
Mobility in Soil: Low mobility; compound is mainly immobile in soil matrices, but can contaminate groundwater over time if released in quantity
Other Effects: Prevent large releases to environment to avoid harm to aquatic organisms in water supply
Waste Disposal Methods: Must dispose in compliance with federal, state, and local regulations; incineration at approved chemical waste facility preferred
Contaminated Packaging: Empty containers should be triple rinsed, punctured, and disposed at hazardous waste facility
Precautions: Do not allow to enter sewers, waterways, or soil
RCRA Status: List waste codes as appropriate for brominated and thiophene compounds
UN Number: Not assigned for this compound
Proper Shipping Name: Chemicals, N.O.S. (Not Otherwise Specified)
Transport Hazard Class: Not classified as dangerous for transport by ADR/RID/IMDG/IATA
Packing Group: Not applicable
Environmental Hazards: Marine pollutant, avoid accidental release during transport
Special Precautions for User: Protect against physical damage, label containers clearly as hazardous; provide safety datasheet with shipment
TSCA Inventory: Compound not listed specifically, use for research and development only
REACH Registration: Not fully registered; limited tonnage exemption for laboratory use
SARA Title III / CERCLA: Not listed in SARA 302/304/313 Categories; brominated compounds may have reporting requirements under local rules
OSHA Hazards: Acute toxicity, skin and eye irritant
WHMIS Classification (Canada): D2B (Toxic Material Causing Other Toxic Effects)
Other Regulations: Always consult local, state, and federal regulations regarding transport, storage, and use
