Product Name: (4S)-4-(Phenylsulfanyl)-L-Proline
Synonyms: 4-Phenylthio-L-proline
Chemical Family: Amino acid derivative
Recommended Use: Laboratory chemical, pharmaceutical research, chemical synthesis
Supplier: Research laboratories and chemical distributors with proper clearance
Contact Information: Emergency telephone and supplier contact details provided on purchase documentation
CAS Number: 112224-18-7
Molecular Formula: C11H13NO2S
Molecular Weight: 223.3 g/mol
GHS Classification: Not classified as hazardous according to GHS standards for this concentration and form
Potential Health Effects: Causes mild skin or eye irritation based on analog compounds; ingestion or inhalation can lead to nausea, headaches, dizziness; pre-existing respiratory or skin conditions may worsen on exposure
Pictograms: None typically required for solid form, but consider general warning
Signal Word: None assigned, but prudent to treat as a low-level irritant
Precautionary Statements: Avoid breathing dust, wash hands after use, use adequate ventilation, prevent contact with skin and eyes, do not eat or drink while handling
Emergency Overview: Dry powder with faint odor, minimal immediate physical danger, can irritate sensitive individuals, not immediately flammable but may evolve toxic vapors if combusted
Chemical Name: (4S)-4-(Phenylsulfanyl)-L-Proline
Purity: ≥97% typical for research grade
Impurities: Minimal, likely other minor organic residues from synthesis; details available on request
CAS Number: 112224-18-7
EC Number: Not listed
Other Ingredients: None intentionally present
Eye Contact: Flush immediately with plenty of water for several minutes; remove contact lenses if easily possible; seek medical attention if irritation persists
Skin Contact: Wash thoroughly with soap and water; remove contaminated clothing; seek medical attention if symptoms persist
Inhalation: Move person to fresh air; support breathing as necessary; seek medical advice if feeling unwell
Ingestion: Rinse mouth; do not induce vomiting unless directed by a medical professional; seek medical attention if large amounts swallowed or symptoms develop
Note to Physician: Symptomatic treatment based on clinical judgment; chemical not likely to cause severe toxicity
Suitable Extinguishing Media: Use water mist, dry chemical powder, foam, or carbon dioxide as appropriate for surroundings
Unsuitable Extinguishing Media: Avoid high-pressure water jets as dust dispersal can occur
Special Hazards: Product can decompose under fire conditions producing sulfur oxides, nitrogen oxides, and carbon oxides
Protective Equipment: Firefighters should wear self-contained breathing apparatus and protective clothing to prevent exposure to fumes
Additional Advice: Remove containers if safe to do so; cool with water spray to prevent further damage
Personal Precautions: Wear appropriate personal protective equipment; avoid generating dust or breathing powder; ventilate the area
Environmental Precautions: Prevent run-off to sewers or waterways; avoid dispersal of dust into the environment
Methods for Cleanup: Sweep up using dust-minimizing techniques (e.g., damp cloth or HEPA vacuum); collect in suitable, closed container for disposal; wash area with water afterward
Decontamination Procedures: Wipe surfaces thoroughly, dispose cleaning materials as chemical waste
Handling: Avoid inhalation of dust, contact with skin and eyes; practice good industrial hygiene; use in well-ventilated areas or under fume hood
Storage Conditions: Store tightly closed in a cool, dry, well-ventilated area, away from incompatible materials such as strong oxidizers and acids
Incompatibilities: Strong acids, strong oxidizing agents, bases
Packaging: Keep in original container or compatible chemical storage vessel, with clear labeling indicating identity and hazard
Other Advice: Restrict access to trained personnel; avoid cross-contamination with food, animal feeds, personal items
Engineering Controls: Use in chemical fume hood or equivalent enclosure to prevent dust exposure; ensure adequate general ventilation
Personal Protective Equipment: Chemical protective glasses or goggles, laboratory coat, gloves resistant to chemical penetration (nitrile or latex), suitable respiratory protection if dust forms
Hygiene Measures: Wash hands thoroughly before eating, drinking, or smoking after handling; remove contaminated clothing before leaving work area
Exposure Limits: No specific occupational exposure limits established; handle as potentially hazardous chemical
Environmental Controls: Adequate measures to prevent dust release or escape to public wastewater
Appearance: White to off-white powder
Odor: Faint, non-specific odor
pH: Data not determined, likely neutral in aqueous solution
Melting Point: Typically ranges around 180–185°C
Boiling Point: Not applicable; decomposition may occur before boiling
Solubility: Slightly soluble in water; soluble in polar organic solvents (e.g., DMSO, methanol)
Vapor Pressure: Negligible
Density: Approx. 1.3 g/cm³
Partition Coefficient (log Kow): Not available
Flammability: Not classified as flammable, but fine dust may form explosive mixtures in air
Other Data: Stable under recommended storage conditions
Chemical Stability: Stable under normal laboratory and storage conditions
Conditions to Avoid: Excessive heat, formation of dust, exposure to light, moisture; avoid exposure to incompatible chemicals
Incompatible Materials: Strong acids, strong oxidizers, strong bases
Hazardous Decomposition Products: Sulfur oxides, carbon oxides, nitrogen oxides on combustion or thermal decomposition
Polymerization: No hazardous polymerization expected
Acute Toxicity: No comprehensive toxicological studies; based on related compounds, low toxicity is expected; ingestion may irritate gastrointestinal tract
Skin Contact: May cause mild irritation or redness with prolonged contact based on reported clinical experience with similar substances
Eye Contact: May cause mild irritation; flushing recommended
Inhalation: Dust inhalation may provoke irritation of respiratory tract, coughing, sneezing
Chronic Toxicity: No data for chronic effects; not known as carcinogenic, mutagenic, or teratogenic according to available literature
Sensitization: Not reported as sensitizer
Other Health Effects: Not expected to cause systemic effects in small, well-controlled quantities
Ecotoxicity: No actual environmental hazard studies are published; expect low toxicity to aquatic organisms due to structure and low usage volumes
Persistence and Degradability: Limited data, but based on related amino acid derivatives, moderate biodegradability may be assumed
Bioaccumulative Potential: No significant potential for bioaccumulation given water solubility and structure
Mobility in Soil: Likely low; material will stay near source unless physically dispersed
Other Adverse Effects: No known major ecological hazards for small-scale laboratory waste; caution should be exercised to avoid release in significant amounts to waterways
Waste Treatment Methods: Dispose of product in accordance with local, regional, and national regulations; preferably in chemical incinerator with appropriate safeguards
Container Disposal: Rinse empty containers with water, then dispose as chemical waste; avoid reuse for any other purpose
Additional Information: Small quantities may be diluted and flushed with copious water if allowed by local regulations; laboratory waste minimization procedures recommended
Regulatory Compliance: Confirm final disposal with local environmental agency as requirements can change
UN Number: Not regulated for transport in most jurisdictions
UN Proper Shipping Name: Not required
Transport Hazard Class: Not classified as a hazardous material for road, rail, air, or sea
Packing Group: Not assigned
Environmental Hazards: Not regarded as marine pollutant
Special Precautions for User: Keep container tightly closed and well-labeled during transit; protect from high temperatures and moisture
Transport in Bulk: Not applicable for this compound due to packaging and shipment in small amounts
Classification: Product not listed under major chemical control conventions (REACH, TSCA, DSL), but restrictions may exist for use based on local regulation
Labelling: Proper labeling required for in-house and transport, showing identity, hazard, and supplier contact
Workplace Control: Chemical Hygiene Plan and laboratory safety protocols apply in occupational settings
SARA 311/312: Not applicable
State Regulations: Refer to regional chemical safety and environmental rules
International Inventories: Product may not appear on chemical inventories; users responsible for ensuring compliance with import and research use laws
Other: Only trained personnel should handle substance; safety training and recordkeeping on handling and exposure recommended by institutional best practice guides
