Product Name: (4S)-4-Cyclohexyl-L-Proline
Synonyms: 4-Cyclohexyl-L-proline, L-Proline, 4-cyclohexyl-, (4S)-
CAS Number: 117421-25-9
Recommended Use: Laboratory chemicals, synthesis of pharmaceutical intermediates
Manufacturer/Supplier: Refer to product label
Emergency Phone: Refer to local poison control or safety officer
Classification: Eye irritation (Category 2A), Skin irritation (Category 2), Specific target organ toxicity – Single exposure (Category 3)
GHS Label Elements: Signal Word: Warning
Hazard Statements: Causes skin and eye irritation. May cause respiratory irritation.
Precautionary Statements: Avoid breathing dust. Wash thoroughly after handling. Use in a well-ventilated area. Wear protective gloves and eye protection. If in eyes: Rinse cautiously, seek medical advice. If inhaled: Move to fresh air, seek medical attention if symptoms persist.
Chemical Name: (4S)-4-Cyclohexyl-L-Proline
CAS Number: 117421-25-9
EC Number: Not available
Purity: ≥98%
Impurities: May include negligible traces of structurally related proline derivatives (varies by batch)
Formula: C11H19NO2
Molecular Weight: 197.28 g/mol
Inhalation: Remove victim to fresh air. Seek medical attention if respiratory irritation or distress occurs. If breathing is difficult, administer oxygen.
Skin Contact: Remove contaminated clothing. Wash area thoroughly with soap and water. If irritation develops or persists, get medical advice.
Eye Contact: Rinse cautiously with water for at least 15 minutes, lifting eyelids occasionally. Remove contact lenses if present and easy to do. Obtain medical attention if discomfort continues.
Ingestion: Rinse mouth thoroughly with water; never give anything by mouth to an unconscious person. Obtain medical attention if symptoms appear.
Suitable Extinguishing Media: Dry chemical, carbon dioxide, water spray, or foam. Avoid using high-pressure water jets.
Specific Hazards: Combustion may produce hazardous gases such as carbon monoxide, carbon dioxide, and nitrogen oxides.
Protective Equipment: Firefighters require self-contained breathing apparatus and protective clothing.
Special Procedures: Cool exposed containers with water spray. Prevent run-off from entering drains or water bodies.
Personal Precautions: Evacuate area. Ensure adequate ventilation. Wear respiratory protection and gloves.
Environmental Precautions: Stop leak if safe to do so. Prevent material from entering drains, surface water, and soil.
Methods for Clean-Up: Use inert absorbent material for spills. Sweep up and place in a labeled container for proper disposal. Wash spill site with water after material pickup is complete.
Decontamination: Ensure all surfaces are thoroughly cleaned to reduce risk of subsequent exposure.
Handling: Handle in accordance with standard laboratory practices. Avoid dust generation. Avoid inhalation, ingestion, and contact with skin and eyes. Use only with adequate ventilation.
Storage: Store in tightly closed original container in a cool, dry, well-ventilated area, away from incompatible substances such as strong oxidizers and acids. Protect from light and moisture.
Incompatible Materials: Strong oxidizing agents, strong acids.
Storage Class: Chemical storage, non-flammable solids.
Engineering Controls: Work in a chemical fume hood or use local exhaust ventilation to minimize dust or aerosol exposure.
Personal Protection Equipment: Wear protective gloves (nitrile or neoprene), safety goggles, and lab coat. Use approved respirator for dust if needed.
Hygiene Measures: Wash hands thoroughly after handling. Remove contaminated clothing and wash before reuse.
Exposure Limits: No specific occupational exposure limits set for this compound. Keep exposures as low as reasonably achievable.
Appearance: White to off-white crystalline powder
Odor: Odorless or faintly characteristic
Odor Threshold: Not determined
pH: Not available (aqueous solutions may be slightly acidic)
Melting Point/Range: 190-204 °C (literature reference)
Boiling Point: Not determined (decomposes before boiling)
Flash Point: Not applicable
Flammability: No data; expected not flammable under normal conditions
Vapor Pressure: Negligible at room temperature
Solubility: Moderately soluble in water, methanol, ethanol; low in nonpolar solvents
Partition Coefficient (n-octanol/water): Not established
Auto-Ignition Temperature: No data
Decomposition Temperature: Decomposes upon strong heating
Viscosity: Not applicable for solid
Chemical Stability: Stable under recommended storage conditions.
Reactive Hazards: May react vigorously with strong oxidizing agents.
Conditions to Avoid: Excessive heat, open flames, strong light, moisture.
Incompatible Materials: Strong oxidizers, acids.
Hazardous Decomposition Products: Oxides of carbon, nitrogen-containing gases, other toxic fumes.
Acute Toxicity: No human toxicity data available; oral and dermal exposure unlikely to pose acute risk at low concentrations.
Routes of Exposure: Inhalation, skin and eye contact, ingestion.
Symptoms: Irritation of eyes, skin, and upper respiratory tract. Prolonged exposure may trigger headaches, dizziness, or mild gastrointestinal symptoms.
Chronic Effects: No long-term hazard identified; not classified based on available data.
Carcinogenicity: Not listed by IARC, ACGIH, NTP, or OSHA.
Mutagenicity: No data
Reproductive Toxicity: No data
Sensitization: No known cases, but some proline derivatives may cause mild sensitization in predisposed individuals.
Aquatic Toxicity: No specific data; estimated low toxicity based on structural similarities to amino acids.
Persistence and Degradability: Expected to be biodegradable under typical environmental conditions due to proline structure.
Bioaccumulation Potential: Low, not expected to accumulate in aquatic organisms
Mobility in Soil: Moderate, depending on conditions; water solubility could allow some migration in soil
Other Adverse Effects: Significant environmental effects unlikely at standard laboratory or industrial use scales.
Waste Treatment Methods: Dispose of as chemical waste according to local, regional, and national regulations.
Disposal of Contaminated Packaging: Rinse containers with water, dispose of in landfill or through licensed waste contractors.
Other Disposal Recommendations: Never release unused product directly to the environment or drains; collect all excess material and waste.
UN Number: Not regulated as a hazardous material by transport agencies.
Proper Shipping Name: Not restricted
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: Not known to pose significant hazards in transportation
Special Precautions for User: Keep container tightly sealed and upright in transport. Avoid excessive vibration and physical impacts.
US TSCA: Not listed
REACH Status: Not registered; research or intermediate use may qualify for exemptions
OSHA Hazard Classification: Irritant
SARA Title III Sections 302, 304, 311, 312, 313: Not listed
DSL/NDSL (Canada): Not listed
WHMIS Classification: Not classified as hazardous
Other Regulatory Info: Subject to local and national chemical safety and environmental protection rules; users must comply with relevant workplace legislation.
