Chemical Name: 4-Piperidylmethylamine
Synonyms: 1-(Aminomethyl)piperidine; para-Piperidylmethylamine
CAS Number: 4005-98-7
Molecular Formula: C6H14N2
Molecular Weight: 114.19 g/mol
Recommended Use: Chemical research, pharmaceutical intermediate, industrial synthesis
Supplier Information: Supply company name, address, emergency contact number, email for safety officer
GHS Classification: Acute Toxicity (Oral, Dermal, Inhalation), Skin Corrosive/Irritant, Eye Damage/Irritation, Specific Target Organ Toxicity
Hazard Statements: Harmful if swallowed, causes severe skin burns and eye damage, may cause respiratory irritation
Pictograms: Corrosive, Exclamation mark
Signal Word: Danger
Precautionary Statements: Do not breathe fumes, mist, vapors, or spray; wash hands thoroughly after handling; wear protective gloves/protective clothing/eye protection/face protection; if swallowed: call poison control center/doctor if you feel unwell; if on skin (or hair): remove immediately all contaminated clothing. Rinse skin with water/shower; if in eyes: rinse cautiously with water for several minutes; remove contact lenses, if present and easy to do—continue rinsing; store locked up
Chemical Name: 4-Piperidylmethylamine
Common Name: 1-(Aminomethyl)piperidine
Purity: >98% by HPLC analysis
Impurities: Less than 1% (ask supplier for specifics)
Additives: None reported
Classification: Not considered a mixture
Inhalation: Remove to fresh air immediately—keep person comfortable, monitor for signs of respiratory distress, seek medical attention if symptoms persist
Skin Contact: Wash skin thoroughly with plenty of water; use soap if available; remove contaminated clothing and shoes; get medical advice for irritation; launder contaminated clothing before reuse
Eye Contact: Rinse cautiously with plenty of water for at least 15 minutes, lifting eyelids occasionally; remove contact lenses if possible; seek immediate medical attention, as damage can be severe
Ingestion: Do not induce vomiting; rinse mouth with water; offer water to drink if the person is fully conscious; seek immediate medical assistance or call poison control
General Notes: Take safety data sheet with patient when seeking medical care; provide supporting information to healthcare provider
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, CO2
Unsuitable Media: Strong water jets may spread the substance
Specific Hazards: Thermal decomposition produces toxic fumes of nitrogen oxides, carbon monoxide, carbon dioxide
Protective Equipment: Firefighters wear self-contained breathing apparatus (SCBA) and full protective clothing
Firefighting Instructions: Stay upwind, keep out of low areas, ventilate enclosed spaces after fire
Explosion Data: Not sensitive to impact; not sensitive to static discharge; may form combustible mixtures with air at higher temperatures
Personal Protection: Avoid contact with skin, eyes, or clothing; ventilate area; use appropriate personal protective equipment including gloves, goggles, and respiratory protection
Spill Cleanup: Absorb spill with inert material—such as sand, earth, or vermiculite; collect in a suitable waste container for proper disposal; avoid raising dust or aerosol; do not touch damaged containers or spilled substance without proper PPE
Environmental Precautions: Prevent runoff into drains, sewers, waterways; notify authorities if substantial release occurs
Decontamination: Wash area with plenty of water, ventilate, and check local guidance for further clean-up procedures
Safe Handling: Avoid inhalation, ingestion, and skin contact; use only in well-ventilated areas, in a chemical fume hood if possible; keep containers tightly closed when not in use; avoid contact with incompatible substances
Storage Conditions: Keep at room temperature or below, away from direct sunlight and moisture; store in tightly closed, labeled containers in a secure, cool, well-ventilated place
Incompatible Materials: Strong oxidizers, acids, acid chlorides, acid anhydrides
Special Requirements: Provide secondary containment, ground and bond bulk containers, handle under inert atmosphere if necessary for purity
Occupational Exposure Limits: No OSHA or ACGIH exposure limits established; minimize exposure as a precaution
Engineering Controls: Provide local exhaust ventilation; use with chemical fume hood if available; use closed transfer systems or adequate containment
Personal Protective Equipment: Chemical-resistant gloves (nitrile, neoprene), safety goggles, full face shield if splash risk, lab coat, flame-resistant protective clothing; use NIOSH-approved respirator if exposure risk warrants
Hygiene Measures: Do not eat, drink, or smoke while handling; wash hands thoroughly after handling; change contaminated clothing before re-use
Monitoring: Air monitoring may be required to determine exposures; consult safety officer for specific protocols
Appearance: Colorless to light yellow liquid
Odor: Characteristic amine odor
Odor Threshold: Not established
pH: Slightly basic in water solution
Melting Point: -20°C (approximate)
Boiling Point: 188–190°C (at 760 mmHg)
Flash Point: 82°C (closed cup, estimate)
Evaporation Rate: Data not available
Flammability: Combustible liquid
Upper/Lower Flammability/Explosive Limits: Not established
Vapor Pressure: Very low at room temperature
Vapor Density: Heavier than air
Specific Gravity: 0.93–0.97 g/mL (20°C)
Solubility: Miscible with water, alcohol, ether
Partition Coefficient (log Kow): Not measured
Autoignition Temperature: Not available
Decomposition Temperature: Not established
Viscosity: Moderate at room temperature
Chemical Stability: Stable under recommended storage, away from moisture, acids, strong oxidizers
Reactivity: Reacts violently with acid chlorides, acid anhydrides, and strong oxidizing agents
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, ammonia
Polymerization: Not expected to occur
Conditions to Avoid: Heat, sparks, open flames, exposure to strong acids or oxidizers, moisture
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Effects: Irritation of respiratory tract, nausea, discomfort, burns to skin and eyes, diarrhea, vomiting on ingestion
Chronic Effects: Repeated exposure may cause liver, kidney, or CNS effects—consult studies in comparable amines
LD50 (Oral, Rat): 250–400 mg/kg (estimate, based on amine class)
LD50 (Dermal, Rabbit): Not measured; use precautions until more data becomes available
Skin Sensitization: Repeated exposure can cause dermatitis
Carcinogenicity: No IARC, NTP, OSHA listing
Mutagenicity/Teratogenicity: Insufficient data available
Target Organs: Eyes, skin, respiratory tract, liver, kidney
Ecotoxicity: Harmful to aquatic organisms (fish, invertebrates, algae); high biological oxygen demand if discharged
Persistence and Degradability: Moderately degradable by hydrolysis or microbial action, but persistence possible in low-oxygen conditions
Bioaccumulative Potential: Low due to water solubility
Mobility in Soil: High potential for migration due to miscibility with water; may contaminate groundwater
Other Adverse Effects: Data lacking for specific chronic effects in wild species; minimize release
Waste Disposal Method: Follow local environmental regulations; do not pour down drain or release to environment; incineration by licensed chemicals disposal service preferred
Contaminated Packaging: Rinse thoroughly before disposal or return to supplier; handle as hazardous waste
Special Instructions: Label waste containers clearly, segregate from incompatible materials, avoid aerosol creation during transfer
UN Number: UN2734
UN Proper Shipping Name: Amines, liquid, corrosive, n.o.s. (4-Piperidylmethylamine)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: II
Special Precautions for Transport: Keep containers upright and tightly sealed; protect from physical damage; provide proper labeling and safety documentation
Environmental Hazards: Marine pollutant; report spillage immediately
Transport Label Required: Corrosive substances label, with UN2734 code
OSHA: Not classified as a specific hazardous substance—general hazard communication applies
TSCA (USA): Listed
REACH (EU): Compliance required; substance registration status subject to annual updates
DSL/NDSL (Canada): Listed on DSL
EINECS/ELINCS (EU): EINECS 223-760-9
SARA Title III Sections 302/313: Not listed
California Prop 65: Not listed
WHMIS (Canada): D2B (skin/eye irritant)
Other International: Consult country-specific regulations, as 4-Piperidylmethylamine is considered a research chemical in some regions
