MSDS – 4-Piperidinecarboxylic Acid

Identification

Product Name: 4-Piperidinecarboxylic Acid
Chemical Formula: C6H11NO2
Synonyms: Piperidine-4-carboxylic acid, Piperidine-4-acetic acid
CAS Number: 499-96-7
Recommended Use: Intermediate for pharmaceutical synthesis, research applications
Supplier: Industrial chemicals supplier, address and emergency contact as per local regulations
Emergency Contact Number: Provided by local distributor or supplier

Hazard Identification

Classification: Eye irritant (Category 2A), Skin irritant (Category 2), Acute toxicity oral (Category 4)
GHS Label Elements: Exclamation mark, Hazard statement, Precautionary statement
Hazard Statements: Causes skin irritation, causes serious eye irritation, harmful if swallowed
Precautionary Statements: Wear protective gloves and eye protection, wash hands thoroughly after handling, avoid inhaling dust or fumes
Potential Health Effects: Irritation to skin/eyes, possible respiratory effect if inhaled in powder form, gastrointestinal irritation if ingested

Composition / Information on Ingredients

Chemical Name: 4-Piperidinecarboxylic Acid
Concentration: ≥98%
Impurities: Water and trace organic residues ≤2%
Additives: None intended
Molecular Weight: 129.16 g/mol
EC Number: 207-887-1

First Aid Measures

Inhalation: Move person to fresh air, keep at rest, seek medical attention for difficulty breathing
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water and soap, get medical advice if irritation persists
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing, consult an ophthalmologist
Ingestion: Rinse mouth with water, do not induce vomiting, seek immediate medical assistance
Symptoms: Redness, itching, burning sensation, coughing, nausea

Fire-Fighting Measures

Suitable Extinguishing Agents: Carbon dioxide, dry chemical powder, alcohol-resistant foam, water spray
Hazards from Combustion: Releases nitrogen oxides, carbon monoxide, carbon dioxide under fire conditions
Special Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective gear
Special Precautions: Avoid inhaling vapors, contain water run-off to prevent environmental contamination

Accidental Release Measures

Personal Precautions: Wear chemical-resistant gloves, safety goggles, approved respirator
Environmental Precautions: Prevent further leakage or spillage into drains, surface water, or soil, notify authorities if entry into environment occurs
Cleanup Procedures: Sweep up and collect spilled material into suitable, labeled containers, dispose of according to local regulations, ventilate affected area

Handling and Storage

Safe Handling: Avoid raising dust or aerosol, use in a well-ventilated space, maintain proper hygiene
Storage Conditions: Keep container tightly closed in a cool, dry place, store away from incompatible substances such as oxidizers, acids, and bases
Packaging Materials: Use containers made from materials compatible with organic acids, properly labeled
Incompatible Materials: Strong oxidizing agents, strong acids/bases, reducing agents

Exposure Controls and Personal Protection

Occupational Exposure Limits: No established exposure limits under OSHA, NIOSH, or ACGIH
Engineering Controls: Local exhaust ventilation, fume hood
Personal Protection: Nitrile gloves, lab coat, splash goggles, appropriate NIOSH-approved respirator for dust
Hygiene Measures: Wash hands after use, no food or drink in work area, remove contaminated clothing after exposure

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Mild, characteristic amine odor
Odor Threshold: Not determined
pH (solution): Approximately 6-7 (1% in water)
Melting Point: 221-226°C
Boiling Point: Decomposes before boiling
Solubility: Soluble in water, partially soluble in ethanol
Partition Coefficient (log Kow): Not determined
Vapor Pressure: Negligible at room temperature
Density: About 1.17 g/cm3
Flash Point: Not applicable

Stability and Reactivity

Chemical Stability: Stable under normal conditions, hygroscopic
Reactive Hazards: Exothermic interaction with strong oxidants, acids, or bases
Conditions to Avoid: Excess heat, moisture, contact with incompatible materials
Decomposition Products: Nitrogen oxides, carbon oxides

Toxicological Information

Acute Toxicity: LD50 (oral, rat): Approximately 500 mg/kg, may cause gastrointestinal effects in humans
Skin Corrosion/Irritation: Causes moderate irritation to skin
Serious Eye Damage/Irritation: Risk of serious eye irritation and conjunctival inflammation
Respiratory Sensitization: Inhalation may irritate respiratory tract, prolonged exposure not recommended
Chronic Effects: No confirmed evidence of carcinogenic, mutagenic, or reproductive toxicity effects
Other Information: Long-term inhalation exposure not well-studied, prudent to minimize chronic exposure

Ecological Information

Toxicity: No specific aquatic toxicity data, not expected to bioaccumulate
Persistence/Degradability: Readily biodegradable under standard environmental conditions
Mobility in Soil: Moderate mobility, soluble in water, risk of leaching if released
Bioaccumulation: Low potential for bioaccumulation
Other Adverse Effects: Prevent bulk release into surface water or soil to reduce any environmental impact

Disposal Considerations

Waste Treatment Methods: Comply with local, regional, or national regulations for hazardous waste disposal
Disposal of Product: Incinerate at appropriate licensed facility, do not release into the environment
Contaminated Packaging: Clean and recycle if feasible, dispose of as hazardous waste
Other Information: Consult local authorities or chemical waste disposal contractor for further advice

Transport Information

Proper Shipping Name: 4-Piperidinecarboxylic Acid
UN Number: Not classified as dangerous for transport under ADR, DOT, IATA
Packing Group: N/A
Hazard Class: Not regulated
Special Precautions: Ensure containers are secure, dry, undamaged, and labeled during transportation

Regulatory Information

Regulatory Status: Not listed under major chemical regulatory lists such as TSCA, REACH, or DSL for restrictions
Labelling Requirements: Follow GHS or local regulatory requirements for hazard labeling
SARA Title III: Not reportable as an extremely hazardous substance
Other Regulations: Use, storage, and disposal must comply with all applicable federal, state, and local regulations