Product Name: 4-(P-Chlorophenyl)Piperidin-4-Ol
Synonyms: 4-(4-Chlorophenyl)-4-piperidinol
CAS Number: 77121-60-7
Recommended Use: Research, chemical synthesis, pharmaceutical intermediate
Manufacturer: Listed by sourcing entity
Emergency Phone: Listed by national chemical emergency response center
Address: Supplied upon request by user or entity
GHS Classification: Acute toxicity (oral, dermal, inhalation), Skin irritation, Serious eye damage
Signal Word: Danger
Hazard Statements: Harmful if swallowed or inhaled, causes skin and serious eye irritation, may cause respiratory tract irritation
Pictograms: Skull and crossbones, exclamation mark, corrosion
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, use only outdoors or in well-ventilated area, wear protective gloves and eye protection, take off contaminated clothing and wash before reuse, in case of inadequate ventilation wear respiratory protection
NFPA Rating: Health: 2, Fire: 1, Reactivity: 0
Chemical Identity: 4-(P-Chlorophenyl)Piperidin-4-Ol
Common Name: 4-(4-Chlorophenyl)-4-piperidinol
Percent Concentration: 98% or above (analytical grade), other components: impurities at less than 2%
Molecular Formula: C11H14ClNO
Molecular Weight: 211.69 g/mol
CAS Number: 77121-60-7
Inhalation: Move exposed person to fresh air and keep at rest, seek medical attention if discomfort or symptoms continue; provide oxygen if breathing is difficult
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with soap and water for several minutes, seek medical attention for persistent irritation
Eye Contact: Rinse eyes with slow, gentle stream of water for at least 15 minutes, keep eyelids open, remove contact lenses if present and easy to do, get medical attention
Ingestion: Rinse mouth, never give anything by mouth to an unconscious person, do not induce vomiting, seek immediate medical attention
Important Symptoms: May cause burning, irritation, cough, redness, shortness of breath, abdominal pain
Advice to Physician: Treat symptoms, monitor for respiratory or central nervous system effects
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, water spray
Unsuitable Extinguishing Media: Direct water jet may broadcast contamination
Specific Hazards: May give off toxic fumes of hydrochloric acid, nitrogen oxides, and carbon monoxide under fire conditions
Protective Equipment: Self-contained breathing apparatus and full protective gear for fire-fighting teams
Fire Fighting Instructions: Move containers from fire area if possible without risk, use water spray to cool unopened containers
Explosion Data: No data on sensitivity to mechanical impact or static discharge, dust may form explosive mixture with air when finely divided
Personal Precautions: Evacuate unnecessary personnel, avoid contact with skin and eyes, avoid dust formation, ensure proper ventilation
Environmental Precautions: Prevent release to drains, surface water, or soil, contain spillage using suitable absorbents
Spill Cleanup Methods: Collect spillage with non-sparking tools, sweep or vacuum material into a closed, labeled container for proper disposal, wash area with mild detergent and water
Protective Measures: Use recommended personal protective equipment at all times during clean-up
Precautions for Safe Handling: Avoid ingestion, inhalation, and skin or eye contact, manipulate chemical in a fume hood or with adequate local exhaust, wear appropriate protective clothing and equipment, wash hands thoroughly after handling
Conditions for Safe Storage: Keep tightly sealed in a cool, dry, well-ventilated place, store away from incompatible substances such as strong oxidizing or reducing agents, acids or bases
Storage Temperature: Below 25°C recommended, protect from light, moisture, and heat
Packaging: Use shatterproof, properly labeled containers
Engineering Controls: Local exhaust ventilation, safety shower, eyewash station required at work site
Control Parameters: No occupational exposure limits formally established for this compound; minimize exposure as much as feasible
Personal Protection: Splash-proof goggles or face shield, nitrile or neoprene gloves, flame-resistant laboratory coat, use of approved dust respirator in case of insufficient ventilation
Hygiene Measures: Remove and wash contaminated clothing before reuse, avoid eating, drinking, or smoking in work areas
Appearance: White to off-white crystalline powder
Odor: Odorless or faint chemical smell
Odor Threshold: No data available
pH: No information available, likely neutral in solution
Melting Point: 97–102°C
Boiling Point: Data not available, decomposes before boiling
Solubility: Sparingly soluble in water, soluble in ethanol, methanol, DMSO
Partition Coefficient (log Kow): Estimated 2.5–3.0
Vapor Pressure: Not measurable at room temperature
Density: Approximate 1.20–1.28 g/cm³
Flash Point: No data, likely above 150°C
Evaporation Rate: Not applicable
Flammability: Not classified as flammable, forms combustible dust clouds
Vapor Density: Not applicable
Autoignition Temperature: Not available
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: No dangerous reactions known under normal conditions
Conditions to Avoid: Excessive heat, moisture, exposure to light, ignition sources
Incompatible Materials: Strong oxidizers, strong acids and bases, reducing agents
Decomposition Products: Hydrochloric acid, chlorinated compounds, nitrogen oxides, carbon oxides may form upon combustion
Acute Toxicity: Oral and dermal LD50 data not fully established; based on structure, considered moderately toxic
Skin Corrosion / Irritation: Causes irritation on prolonged or repeated exposure; redness, dryness, discomfort likely
Serious Eye Damage / Irritation: Causes damage upon direct contact, risk of corneal injury
Respiratory Sensitization: Irritation to nose, throat, and respiratory system upon inhalation of dust
Chronic Effects: Data not available; possible targeting of central nervous system or other organs with extended exposure
Carcinogenicity: Not listed by IARC, NTP, or OSHA
Mutagenicity: No data available
Reproductive Effects: No animal study data present
Ecotoxicity: Hazard to aquatic life not fully characterized, structurally related compounds may be toxic at high concentrations
Persistence and Degradability: Likely persistent in soil and water, limited biodegradability
Bioaccumulative Potential: Moderate bioaccumulation expected due to log Kow between 2.5–3.0
Mobility in Soil: Limited due to limited water solubility
Other Effects: Avoid contamination of groundwater, monitor discharge practices, inform relevant authorities if significant spillage occurs
Disposal Methods: Dispose according to local, regional, and national regulations; do not discharge into sewer systems, bodies of water, or uncontrolled landfills
Contaminated Packaging: Rinse containers, manage as chemical waste
Special Instructions: Incinerate in chemical incinerator equipped with scrubber; consult qualified waste disposal firm for options
UN Number: Not assigned for common forms
Proper Shipping Name: Not classified as dangerous under most transport regulations
Transport Hazard Class: Not regulated
Packing Group: Not established
Marine Pollutant: Not listed
Special Precautions: Secure containers, keep well-labeled, ensure compliance with all applicable national and international regulations for chemical transport
US Federal Regulations: Not subject to specific reporting or control under SARA Title III, CERCLA, or RCRA; review DEA and FDA rules for controlled chemical intermediates
TSCA Status: May require exemption or notification status; not listed for routine commercial use
EU Regulations: May fall under REACH provisions for import, use, and disposal; safety data sheet required for communication
Other Country-Specific Regulation: Japan CSCL, Australia AICS, Canada DSL may apply based on purpose and quantity
Labeling Information: Appropriate hazard pictograms, signal words, and statements necessary for storage and transfer
